Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(45)
Published: Sept. 17, 2024
Abstract
The
overexpression
of
polyamines
in
tumor
cells
contributes
to
the
establishment
immunosuppressive
microenvironment
and
facilitates
growth.
Here,
it
have
ingeniously
designed
multifunctional
copper‐piceatannol/HA
nanopills
(Cu‐Pic/HA
NPs)
that
effectively
cause
total
intracellular
depletion
by
inhibiting
synthesis,
depleting
polyamines,
impairing
uptake,
resulting
enhanced
pyroptosis
cuproptosis,
thus
activating
a
powerful
immune
response
achieve
anti‐tumor
therapy.
Mitochondrial
dysfunction
from
overall
not
only
leads
surge
copper
ions
mitochondria,
thereby
causing
aggregation
toxic
proteins
induce
but
also
triggers
accumulation
reactive
oxygen
species
(ROS)
within
which
further
upregulates
expression
zDHHC5
zDHHC9
promote
palmitoylation
gasdermin
D
(GSDMD)
GSDMD‐N,
ultimately
inducing
pyroptosis.
Then
occurrence
cuproptosis
is
conductive
remodel
microenvironment,
responses
growth
metastasis.
This
therapeutic
strategy
through
comprehensive
provides
novel
template
for
cancer
immunotherapy.
Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
30, P. 101441 - 101441
Published: Jan. 1, 2025
The
therapeutic
effect
of
immune
checkpoint
inhibitors
(ICIs)
in
triple-negative
breast
cancer
(TNBC)
is
unsatisfactory.
"cold"
microenvironment
caused
by
tumor-associated
fibroblasts
(TAFs)
has
an
adverse
on
the
antitumor
response.
Therefore,
this
study,
mixed
cell
membrane-coated
porous
magnetic
nanoparticles
(PMNPs)
were
constructed
to
deliver
salvianolic
acid
B
(SAB)
induce
response,
facilitating
transition
from
a
"hot"
tumor
and
ultimately
enhancing
efficacy
inhibitors.
PMNP-SAB,
which
based
coating
red
blood
membrane
TAF
(named
PMNP-SAB@RTM),
can
simultaneously
achieve
dual
effects
"immune
escape"
"homologous
targeting".
Under
influence
external
field
(MF),
SAB
be
targeted
concentrated
at
site.
released
tumors
effectively
inhibit
production
extracellular
matrix
(ECM)
TAFs,
promote
T-cell
infiltration,
responses.
Ultimately,
combination
PMNP-SAB@RTM
BMS-1
(PD-1/PD-L1
inhibitor
1)
inhibited
growth.
Finally,
study
presents
precise
effective
new
strategy
for
TNBC
immunotherapy
basis
differentiation
microenvironments.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 23, 2025
Abstract
Engineered
modifications
of
nanomaterials
inspired
by
nature
hold
great
promise
for
disease‐specific
imaging
and
therapies.
However,
conventional
polyethylene
glycol
modification
is
limited
immune
system
rejection.
The
manipulation
gold
nanorods
(Au
NRs)
modified
endogenous
proteins
(eP@Au)
reported
as
an
engineered
biomodulator
enhanced
breast
tumor
therapy.
results
show
that
eP@Au
NRs
neither
activate
inflammatory
factors
in
vitro
nor
elicit
rejection
responses
vivo.
Tumor‐specific
exhibit
a
dual‐modal
capability
trigger
mild
photothermal
effect
under
near‐infrared
light
irradiation,
enabling
highly
efficient
therapy
tumors.
Transcriptome
sequencing
confirmatory
experiments
reveal
the
antitumor
mainly
attributed
to
repression
PI3K‐Akt/MAPK
signaling
pathways
at
molecular
level.
This
powerful
surprising
situ
eP‐regulated
biomodulation
demonstrates
advantages
convenient
fabrication,
inert
immunogenicity,
biocompatibility,
providing
alternative
strategy
biomedical
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 10, 2025
The
dynamic
process
in
tumor
ablation
requires
both
the
generation
of
reactive
oxygen
species
(ROS)
to
elicit
immunogenic
cell
death
(ICD)
and
subsequent
reduction
ROS
levels
maintain
stimulatory
activity
signaling
proteins
recover
T
cells'
immune
function.
Inspired
by
regulation
mechanism
redox
homeostasis
myeloid-derived
suppressor
cells
high-selectivity
alcohols/aldehydes
conversions
2,2,6,6-tetramethylpiperidine-1-oxyl
(TEMPO)
Fe(III)
synergistic
catalysis,
photoenzymatic
modulators
with
contradictory
but
functions
are
developed
for
adaptive
photo-immunotherapy
cancer.
In
particular,
poly(caffeic
acid)
(PCA)
nanospheres
synthesized
highly
efficient
oxidative
polymerization
CA.
obtained
π-conjugated
structures
have
an
extended
absorbance
near-infrared
(NIR)
region,
narrow
band
energy
(0.86
eV),
low
exciton
binding
(43.56
meV)
that
lead
polymerization-enhanced
type
I
photosensitization
photostability.
Meanwhile,
abundant
semiquinone
radicals
existing
PCA
bestow
them
superior
antioxidant
Under
NIR
irradiation,
elevated
superoxide
radical
yields
(3.5-fold
compared
CA)
heat
stress
robust
ICD.
When
irradiation
ceases,
active
downregulation
infiltration
lymphocytes
increase
2.7-fold
conventional
photosensitizers.
As
envisaged,
this
work
demonstrates
a
novel
tactic
remodel
effective
inhibition
growth
metastasis.
Exploration,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 6, 2025
ABSTRACT
Nanozyme‐based
immunogenic
cell
death
(ICD)
inducers
that
effectively
induce
a
strong
immune
response
via
enzyme‐like
process
have
attracted
great
attention,
but
how
to
ensure
controllable
active
sites
and
maximize
site
utilization
remains
problem.
Here,
we
report
structurally
well‐defined
highly
functional
single‐site
copper(I)
nanomodulators
termed
CuNTD,
constructed
by
precisely
anchoring
atomically
dispersed
self‐assembly
S‐Cu(I)‐S
onto
two‐dimensional
Ti
3
C
2
surface.
Leveraging
Cu
+
with
higher
catalytic
efficiency
than
2+
,
CuNTD
generates
reactive
oxygen
species
(ROS)
storms
through
photothermal‐enhanced
cascade
catalysis,
further
inducing
mitochondrial
dysfunction,
ferroptosis
cuproptosis.
Multifunctional
triggers
ICD
cascade‐regulatory
pathways
of
photothermal‐amplified
ROS
storms,
cuproptosis
ferroptosis,
promoting
dendritic
maturation
while
reducing
monotherapies
side
effects
resistance.
In
vivo,
combined
FDA‐approved
immunoadjuvants
significantly
prolong
the
survival
mice.
With
its
demonstrated
biosafety
high
as
an
inducer,
this
study
provides
promising
framework
for
advancing
augmented
tumor
immunotherapy
significant
clinical
potential.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 25, 2025
Abstract
Reprogramming
the
tumor
immune
microenvironment
(TIM)
plays
an
important
role
in
promoting
reversal
of
“cold”
tumors
into
“hot”
inflammatory
tumors.
Improving
drug
targeting,
blocking
checkpoints,
and
activation
cells
are
crucial
for
reprogramming
TIM.
Here,
intercellular
adhesion
molecule
1‐targeted
antibody‒drug
conjugate
combination
with
a
B7‐H3‐CD3
bispecific
antibody
is
selected
TIM
reprogramming,
which
improved
efficacy
triple‐negative
breast
cancer
immunotherapy.
This
therapy
improves
blocks
checkpoint
pathways,
activates
effector
T
to
release
cytokines,
leading
immunogenic
cell
death
tumor‐associated
antigens.
effect
promotes
maturation
dendritic
cells,
infiltration
cytotoxic
CD8+
repolarization
M1‐type
macrophages,
reduction
M2‐type
suppressor
Tregs,
MDS
thereby
In
addition,
this
innovative
strategy
accumulation
at
metastasis
sites
significantly
impedes
progression
lung
metastatic
lesions.
Overall,
study
provides
novel
insights
using
immunotherapeutic
strategies
that
leverage
synergistic
effects
antibody‐drug
conjugates
antibodies.
