International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125467 - 125467
Published: March 1, 2025
Language: Английский
Bioactive Materials, Journal Year: 2024, Volume and Issue: 45, P. 301 - 321
Published: Nov. 27, 2024
Language: Английский
Citations
17
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(33)
Published: June 14, 2024
Infectious diseases caused by bacterial, viral, and fungal pathogens present significant global health challenges. The rapid emergence of antimicrobial resistance exacerbates this issue, leading to a scenario where effective antibiotics are increasingly scarce. Traditional antibiotic development strategies proving inadequate against the swift evolution microbial resistance. Therefore, there is an urgent need develop novel with mechanisms distinct from those existing antibiotics. Nanozybiotics, which nanozyme-based antimicrobials, mimic catalytic action lysosomal enzymes in innate immune cells kill infectious pathogens. This review reinforces concept nanozymes provides comprehensive summary recent research advancements on potential candidates. Initially, nanozybiotics categorized based their activities, mimicking either oxidoreductase-like or hydrolase-like functions, thereby highlighting superior combating then discusses progress treating infections, confirming as translational nanozybiotic-based products, including hydrogels, nanorobots, sprays, bandages, masks, protective clothing, also considered. Finally, current challenges future prospects nanozybiotic-related products explored, emphasizing design capabilities for applications.
Language: Английский
Citations
16
Deleted Journal, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 19, 2025
Abstract Wound healing is a complex process that involves multiple stages and susceptible to various challenges, such as infection, insufficient blood flow, the body's inadequate response process, which can be life‐threatening for patient. In current medical landscape, traditional treatments often struggle meet high standards of modern care. Therefore, it crucial actively explore develop new drugs or advanced technologies enhance bacterially infected wounds. recent years, several physical methods effectively accelerate wound have garnered widespread attention interest. Among these, Photothermal therapy (PTT) has been extensively utilized in treatment bacterial infections due its non‐invasive, low toxicity, ease use. The photothermal agents (PTAs) serve core material PTT, their efficacy significantly influenced by specific PTAs employed. Selecting appropriate essential achieving desired therapeutic effect. This relies on PTAs's ability efficiently convert wavelengths light energy into heat upon absorption, thereby generating thermal effect at site. Consequently, properties PTAs, including conversion efficiency, biocompatibility, stability within organism, are critical factors determine outcome. review introduces organic, inorganic, organic‐inorganic hybrid PTT healing, highlighting main applications management years. Finally, we briefly discuss limitations prospects this field.
Language: Английский
Citations
2
Advanced Science, Journal Year: 2024, Volume and Issue: 11(45)
Published: Oct. 11, 2024
Abstract Oral ulcers can be addressed using various biomaterials designed to deliver medications or cytokines. Nevertheless, the effectiveness of these substances is frequently limited in many patients due poor adherence, short retention time mouth, and less‐than‐optimal drug efficacy. In this study, a new hydrogel patch (FSH3) made silk fibroin/hyaluronic acid matrix with light‐sensitive adhesive qualities infused ferric iron/shikonin nanoparticles enhance healing effects presented. Initially, forms an barrier over mucosal lesions through straightforward local injection, solidifying when exposed UV light. Subsequently, FSH3 demonstrates superior reactive oxygen species elimination near‐infrared photothermal bactericidal activity. These characteristics support bacterial regulate oxidative levels, promoting wound's progression from inflammation tissue regeneration. diabetic rat model mimicking oral ulcers, significantly speeds up by adjusting inflammatory environment injured tissue, maintaining balance microbiota, faster re‐epithelialization. Overall, shows potential for rapid wound recovery may transform therapeutic methods managing diabetes.
Language: Английский
Citations
12
ACS Materials Letters, Journal Year: 2024, Volume and Issue: 6(6), P. 2487 - 2496
Published: May 23, 2024
Nanozyme hybrids with photothermally mediated catalytic activity have received increasing attention in addressing the challenges of public health events caused by bacterial infections. However, designing photothermal nanozyme efficient synergistic antibacterial properties remains a challenge but is desirable. Herein, prepared CuxO@PDA (CP) showed excellent conversion efficiency 39.81%. More interestingly, CP also possesses peroxidase-like activity, which could convert H2O2 to •OH, and capability was improved under NIR irradiation. The effect between makes proposed therapy able kill 99.74% Staphylococcus aureus (S. aureus) 99.82% Escherichia coli (E. coli). In vivo experiments further that ability be well applied wound infection treatment. Overall, our work provides insight into design high-efficacy photothermal-mediated compounds for broad-spectrum applications.
Language: Английский
Citations
9
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 279, P. 135301 - 135301
Published: Sept. 3, 2024
Language: Английский
Citations
9
Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(9), P. 1206 - 1206
Published: Sept. 12, 2024
The rise of antibiotic resistance and the dwindling antimicrobial pipeline have emerged as significant threats to public health. emergence carbapenem-resistant
Language: Английский
Citations
8
Materials Today Bio, Journal Year: 2024, Volume and Issue: 29, P. 101265 - 101265
Published: Sept. 23, 2024
Language: Английский
Citations
8
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 500, P. 157299 - 157299
Published: Nov. 1, 2024
Language: Английский
Citations
8
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159226 - 159226
Published: Jan. 1, 2025
Language: Английский
Citations
1