A Possible Tool for Guiding Therapeutic Approaches to Urinary Infections with Klebsiella pneumoniae: Analyzing a Dataset from a Romanian Tertiary Hospital DOI Creative Commons

Dragos Stefan Lazar,

Maria Nica,

Daniel Codreanu

et al.

Antibiotics, Journal Year: 2024, Volume and Issue: 13(12), P. 1170 - 1170

Published: Dec. 3, 2024

Introduction: The emergence of carbapenem-resistant pathogenic bacteria is a growing global public health concern. Carbapenem-resistant uropathogenic strains Klebsiella pneumoniae can cause uncomplicated or complicated urinary tract infections, leading to high risk treatment failure and the spread resistance determinants. objectives this 24-month study were identify prognostic characteristics patients who infected with (CRKpn) create tool estimate probability CRKpn infection before having complete results patient’s antibiogram. Results: We found that 41.6% all infections Kpn caused by CRKpn. Factors such as male gender, presence upper invasive maneuvers, recent carriage germ, nosocomial occurrence UTIs predictive for infection. Based on these factors, we proposed model Methods: A retrospective case–control including hospitalized (UTIs) was carried out. reported data percentages, identified independent predictors CRKpn, evaluate through multivariate analysis. Conclusions: Through study, aim provide clinicians support decision making regarding first-line antibiotic treatment.

Language: Английский

Hypervirulent Klebsiella pneumoniae: Epidemiology outside Asian countries, antibiotic resistance association, methods of detection and clinical management DOI Creative Commons
Silvia García-Cobos, Jesús Calatayud, María Pérez‐Vázquez

et al.

Enfermedades Infecciosas y Microbiología Clínica, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

1
Antibiotic Use in Livestock Farming: A Driver of Multidrug Resistance? DOI Creative Commons

Andreas Matheou,

Ayah Abousetta,

Aphrodite Persephone Pascoe

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(4), P. 779 - 779

Published: March 28, 2025

Antimicrobial resistance (AMR) constitutes a pressing and intensifying global health crisis, significantly exacerbated by the inappropriate utilization excessive application of antibiotics in livestock agriculture. The use antibiotics, including prophylactic metaphylactic administration as well growth-promotion applications, exacerbates selective pressures, fostering proliferation multidrug-resistant (MDR) bacterial strains. Pathogens such Escherichia coli, Salmonella spp., Staphylococcus aureus can be transmitted to humans through direct contact, contaminated food, environmental pathways, establishing clear link between farming human AMR outbreaks. These challenges are particularly pronounced regions with limited veterinary oversight weak regulatory frameworks. Addressing these issues requires implementation sustainable practices, enhanced antibiotic stewardship, strengthened interdisciplinary collaboration. This review underscores critical need for One Health approach mitigate AMR, recognizing interconnectedness human, animal, safeguarding public health.

Language: Английский

Citations

1
Epidemiological and molecular characteristics of carbapenem-resistant Klebsiella pneumoniae from pediatric patients in Henan, China DOI Creative Commons
Jiayue Ma,

Kaijie Gao,

Mingchao Li

et al.

Annals of Clinical Microbiology and Antimicrobials, Journal Year: 2024, Volume and Issue: 23(1)

Published: Nov. 7, 2024

Carbapenem-resistant Klebsiella pneumoniae (CRKP) is an emerging global threat, whereas its epidemiological characteristics in children are rarely reported. This study aims to analyze clinical and of CRKP from Henan, China.

Language: Английский

Citations

4
Hypervirulent Klebsiella pneumoniae: Epidemiology outside Asian countries, antibiotic resistance association, methods of detection and clinical management DOI Creative Commons
Silvia García-Cobos, Jesús Calatayud, María Pérez‐Vázquez

et al.

Enfermedades infecciosas y microbiologia clinica (English ed ), Journal Year: 2025, Volume and Issue: 43(2), P. 102 - 109

Published: Feb. 1, 2025

Two main Klebsiella pneumoniae pathotypes are of public health concern, classical K. (cKP), with high antibiotic resistance acquisition capacity, and hypervirulent (hvKP). The emergence antibiotic-resistant pneumoniae, especially carbapenem resistance, is worrisome require effective methods for detection treatment. Different evolutionary paths contribute to the hypervirulence commonly via plasmids by hvKP (CR-hvKP) or virulence CRKp (hv-CRKp). ST11-KL64 together blaKPC-2, most extended hv-CRKP lineage acquiring associated biomarkers, rmpA, rmpa2, iroBCDEN, iucABCDiutA, peg344. In addition ST11, other clones have been reported in Europe such as ST101, ST147 ST512, highlighting association OXA-48 NDM carbapenemases. Although still very rare Spain, cases increasing recent years, mainly due ST23-K1, ST380-K2 ST86-K2. Management infections requires active therapy based primarily on susceptibility patters site infection.

Language: Английский

Citations

0
Comparative analysis of clinical characteristics and outcomes between carbapenem-resistant and carbapenem-sensitive Klebsiella pneumoniae infections: insights from a tertiary hospital in Northern China DOI Creative Commons
Bu Wang, Wei Zhang, Hongxia Zhang

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 5, 2025

To compare the risk factors, clinical outcomes, and mortality rates between carbapenem-resistant Klebsiella pneumoniae (CRKP) carbapenem-sensitive (CSKP) infections. A retrospective cohort study was conducted on patients with infections admitted to a tertiary hospital in Zhangjiakou, China. The research period is from January 2021 December 2022. Data were analyzed using SPSS 24.0 R. Univariate analysis identified potential factors for CRKP appropriate statistical methods, followed by multivariable logistic regression determine independent factors. Mortality CSKP groups compared chi-square tests, survival curves generated Kaplan-Meier method. included 283 patients, 104 (36.7%) infected 179 (63.3%) CSKP. had significantly higher body temperature, white blood cell counts, inflammatory markers, while showing lower diastolic pressure oxygen saturation (p < 0.05). predominantly found ICU (49%) mainly isolated sputum (59%). Independent elevated C-reactive protein (OR = 1.02) solid tumors 18.186). experienced longer stays (25 days vs. 12 CSKP), (13 7 days), 30-day (23.1% 17.9%, p 0.012). deceased group procalcitonin creatinine levels, prothrombin time, greater need mechanical ventilation survivors Patients than those Previous hospitalization, hospitalization an ICU, infection.

Language: Английский

Citations

0
Evaluation of the Lateral Flow Immunoassay Method for Rapid Detection of Carbapenemase-Producing Escherichia Coli and Klebsiella Pneumoniae at a High-Resistance Setting in Vietnam DOI
Ngoc Bich Tran, Trương Thị Bích Phượng, Van Tran

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
New insights and perspectives on the virulence of hypervirulent Klebsiella pneumoniae DOI
Ifeanyi Elibe,

Toluwalase Odunayo,

Chibuzor Kenneth Uwazie

et al.

Folia Microbiologica, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Language: Английский

Citations

0
Antimicrobial peptide mimic 329 potentiates minocycline against carbapenem-resistant Klebsiella pneumoniae DOI
Yongqing Liu, Tingting Yan,

Hongtao Kong

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 161, P. 108517 - 108517

Published: April 25, 2025

Language: Английский

Citations

0
Is It Time to Start Worrying? A Comprehensive Report on the Three-Year Prevalence of ESBL-Producing Bacteria and Their Trends in Antibiotic Resistance from the Largest University Hospital in Slovakia DOI Creative Commons
Yashar Jalali,

Andrea Kološová,

Adriána Liptáková

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(11), P. 1517 - 1517

Published: Nov. 11, 2024

Over the past few decades, extended-spectrum β-lactamase (ESBL)-producing bacteria have become a great concern in healthcare systems worldwide, imposing large burdens by increasing antimicrobial resistance and patient morbidity. Given high mortality rates emergence of multidrug-resistant (MDR) strains, monitoring ESBL prevalence patterns is crucial. This study aimed to evaluate ESBL-producing

Language: Английский

Citations

0
A Possible Tool for Guiding Therapeutic Approaches to Urinary Infections with Klebsiella pneumoniae: Analyzing a Dataset from a Romanian Tertiary Hospital DOI Creative Commons

Dragos Stefan Lazar,

Maria Nica,

Daniel Codreanu

et al.

Antibiotics, Journal Year: 2024, Volume and Issue: 13(12), P. 1170 - 1170

Published: Dec. 3, 2024

Introduction: The emergence of carbapenem-resistant pathogenic bacteria is a growing global public health concern. Carbapenem-resistant uropathogenic strains Klebsiella pneumoniae can cause uncomplicated or complicated urinary tract infections, leading to high risk treatment failure and the spread resistance determinants. objectives this 24-month study were identify prognostic characteristics patients who infected with (CRKpn) create tool estimate probability CRKpn infection before having complete results patient’s antibiogram. Results: We found that 41.6% all infections Kpn caused by CRKpn. Factors such as male gender, presence upper invasive maneuvers, recent carriage germ, nosocomial occurrence UTIs predictive for infection. Based on these factors, we proposed model Methods: A retrospective case–control including hospitalized (UTIs) was carried out. reported data percentages, identified independent predictors CRKpn, evaluate through multivariate analysis. Conclusions: Through study, aim provide clinicians support decision making regarding first-line antibiotic treatment.

Language: Английский

Citations

0