Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 19, 2024
Effective
delivery
of
therapeutic
agents
for
solid
tumour
treatment
is
impeded
by
multiple
obstacles,
which
causes
impaired
penetration
to
deep
avascular
tissue
that
exists
in
a
hypoxic
immune
cold
environment.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Oct. 12, 2024
Endothelial
cells
(ECs)
are
pivotal
in
maintaining
vascular
health,
regulating
hemodynamics,
and
modulating
inflammatory
responses.
Nanocarriers
hold
transformative
potential
for
precise
drug
delivery
within
the
system,
particularly
targeting
ECs
therapeutic
purposes.
However,
complex
interactions
between
nanocarriers
present
significant
challenges
development
clinical
translation
of
nanotherapeutics.
This
review
assesses
recent
advancements
key
strategies
employing
to
ECs.
It
suggested
that
through
physicochemical
design
surface
modifications,
can
enhance
specificity
improve
internalization
efficiency
Additionally,
we
elaborated
on
applications
specifically
designed
treatment
cardiovascular
diseases,
cancer
metastasis,
disorders.
Despite
these
advancements,
safety
concerns,
complexity
vivo
processes,
challenge
achieving
subcellular
remain
obstacles
effective
with
nanocarriers.
A
comprehensive
understanding
endothelial
cell
biology
its
interaction
is
crucial
realizing
full
targeted
systems.
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 31, 2025
Neighboring
effects
provided
a
valuable
direction
for
in-depth
penetration
of
nanoparticles
into
tumors.
However,
the
uncontrollable
drug
transcytosis
and
limited
uptake
hindered
by
viscous
cancer-associated
fibroblasts
(CAFs)
greatly
limit
their
penetration.
Here,
we
proposed
demonstrated
that
intracellular
autophagosomes
could
carry
remaining
drugs
to
neighboring
cells,
enhanced
macropinocytosis
played
major
role
in
delivery.
To
enhance
autophagosome-based
delivery,
Ca2+-doped
polydopamine
was
prepared
load
GLS1
inhibitor
CB-839
modified
glutamine
(839/CG)
triggering
macropinocytosis-based
active
cells
uptake.
After
Ca2+-release
caused
lysosome
damage,
839/CG
escaped
from
lysosomes
autophagosome
maturation.
Then,
Ca2+-induced
endoplasmic
reticulum
oscillations
starvation
both
increased
blocked
autophagy
flow,
causing
839/CG-contained
accumulation.
Meanwhile,
tumor
its
response
mTOR
downregulation-induced
hunger,
"the
more
you
eat,
hungrier
get".
death,
were
released
actively
ingested
hungry
through
macropinocytosis.
Combined
with
photothermal
effect
triggered
CAF
decrease,
repeated
above
process
Also,
immunogenic
death
antigen
presentation
DCs
infiltration
T
thereby
inhibiting
growth
lung
metastasis.
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 12, 2025
Endolysosomal
degradation
of
small
interfering
RNA
(siRNA)
significantly
reduces
the
efficacy
interference
(RNAi)
delivered
by
nonviral
systems.
Leveraging
Golgi
apparatus/endoplasmic
reticulum
(Golgi/ER)
transport
can
help
siRNA
bypass
endolysosomal
pathway,
but
this
approach
may
also
result
in
insufficient
release
and
an
increased
risk
Golgi/ER-mediated
exocytosis.
To
address
these
challenges,
we
developed
two
distinct
strategies
using
a
nanocomplex
cell-penetrating
poly(disulfide)s
chondroitin
sulfate,
which
enhances
targeted
internalization,
transport,
rapid
cytoplasmic
loaded
siRNA.
In
first
strategy,
monensin
synergy
was
found
to
enhance
RNAi
inhibiting
both
exocytosis
autophagic
degradation.
second
"directed
sorting"
based
on
KDEL
peptide-mediated
retrograde
introduced.
By
conjugation
peptide
Golgi-to-ER
promoted,
reducing
"random"
Golgi/ER-related
These
operate
alternatively
achieve
high-efficiency
with
significant
therapeutic
potential.
Notably,
mouse
melanoma
model
anti-Bcl-2
siRNA,
achieved
tumor
inhibition
rates
87.1
90.1%,
respectively.
strategies,
"targeting"
"anchoring"
Golgi/ER,
provide
potent
solutions
overcome
challenges
cellular
intracellular
release,
efficient
delivery.
Materials Today Bio,
Journal Year:
2024,
Volume and Issue:
27, P. 101119 - 101119
Published: June 11, 2024
Cancer
represents
a
significant
threat
to
human
health,
with
the
use
of
traditional
chemotherapy
drugs
being
limited
by
their
harsh
side
effects.
Tumor-targeted
nanocarriers
have
emerged
as
promising
solution
this
problem,
they
can
deliver
directly
tumor
site,
improving
drug
effectiveness
and
reducing
adverse
However,
efficacy
most
nanomedicines
is
hindered
poor
penetration
into
solid
tumors.
Nanomotors,
capable
converting
various
forms
energy
mechanical
for
self-propelled
movement,
offer
potential
enhancing
delivery
deep
regions.
External
force-driven
nanomotors,
such
those
powered
magnetic
fields
or
ultrasound,
provide
precise
control
but
often
necessitate
bulky
costly
external
equipment.
Bio-driven
propelled
sperm,
macrophages,
bacteria,
utilize
biological
molecules
self-propulsion
are
well-suited
physiological
environment.
constrained
lifespan,
inadequate
speed,
immune
responses.
To
address
these
issues,
nanomotors
been
engineered
propel
themselves
forward
catalyzing
intrinsic
"fuel"
in
microenvironment.
This
mechanism
facilitates
through
barriers,
allowing
them
reach
regions
targeted
delivery.
In
regard,
article
provides
review
microenvironment-activatable
(fueled
hydrogen
peroxide,
urea,
arginine),
discusses
prospects
challenges
clinical
translation,
aiming
new
insights
safe,
efficient,
treatment
cancer
therapy.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 5, 2025
Abstract
For
efficient
anticancer
drug
delivery,
cascade
physiological
barriers
must
be
overcome,
which
requires
the
delivery
vehicles
to
possess
different
or
even
opposite
properties
at
stages.
Poly(tertiary
amine‐oxide)
(PTAO)
polymers
with
zwitterionic
feature
have
distinct
antifouling
in
blood
circulation,
can
reduced
and
protonated
hypoxic
tumors
promote
cellular
internalization.
Nevertheless,
effects
of
various
PTAO
structures
not
been
studied
systemically
optimized.
In
this
report,
side
groups
are
proposed
optimized
by
modulating
structures.
Poly(2‐(
N
‐oxide‐hexamethyleneimino)ethyl
methacrylate)
(POC7A)
a
cyclic
seven‐membered
ring
is
screened
as
structure
for
vivo
applications.
Moreover,
block
copolymer
POC7A‐block‐poly(
ε
‐caprolactone)
(POC7A‐PCL)
prepared
formation
micelles
aqueous
solution
doxorubicin
(DOX).
The
nature
POC7A
shells
bioreductive
activity
protonation
tumor
microenvironment
endows
excellent
long
accumulation,
deep
penetration,
effective
Thus,
DOX‐loaded
exhibit
potent
antitumor
efficacy
after
intravenous
administration.
Zwitterionic
used
nanocarriers
overcome
efficiently.
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 23, 2025
Abstract
Long
blood
circulation
and
fast
cellular
uptake
are
essential
yet
paradoxical
requirements
for
efficient
tumor‐targeted
drug
delivery
carriers.
For
instance,
polyzwitterions,
generally
nonfouling
to
proteins
cells,
have
been
extensively
explored
as
long‐circulating
carriers
but
suffer
ultraslow
cell
internalization,
making
them
inefficient
in
delivering
drugs
cells.
Protein‐resistant
membrane‐binding
polymers
will
simultaneously
achieve
long
their
designs
complicated,
such
introducing
cell‐membrane
binding
groups.
Here,
it
is
shown
that
the
N
‐alkyl
chain
length
of
zwitterionic
poly(sulfobetaine)
can
be
used
tune
its
affinity
toward
membranes.
A
with
a
moderately
became
membrane‐philic
while
retaining
protein
resistance,
leading
uptake,
which
further
triggered
tumor
transcytosis
intratumor
penetration.
Thus,
paclitaxel
(PTX)‐loaded
micelles
demonstrated
potent
antitumor
efficacy
triple‐negative
breast
cancer
models.
This
study
showcases
paradigm
designing
polyzwitterions
harmonizing
properties
tumor‐active