Photo‐Triggered Fluorescence Polyelectrolyte Nanoassemblies: Manipulate and Boost Singlet Oxygen in Photodynamic Therapy DOI Open Access

Yongkang Yao,

Shangjun Chen, Chenxu Yan

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 10, 2024

Abstract Photodynamic therapy (PDT) is a clinically approved therapeutic modality that has shown great potential for cancer treatment. However, there exist two major problems hindering PDT applications: the nonspecific phototoxicity requiring patients to stay in dark post‐PDT, and limited photodynamic efficiency. Herein, we report photo‐triggered porphyrin polyelectrolyte nanoassembling (photo‐triggered PPN) strategy, which photosensitizer photoswitchable energy accepter are assembled into micelles by combined force of charge interaction metal‐ligand coordination. The polyelectrolyte‐based PPN exhibits good biocompatibility, bestows unique “confining isolated” inner microenvironment fully overcoming π–π stacking porphyrins with significant efficiency (123‐fold enhancement). Due high Förster resonance transfer (FRET) (91.5 %) between photoswitch closed‐form, could use light as specific trigger modulate closed‐ open‐form, manipulate 1 O 2 generation three stages: pre‐PDT (quenching generation), during (activating post‐PDT (silencing generation). This de novo strategy first time realized remotely manipulating boosting PDT, well resolving critical general challenges side effects from phototoxicity.

Language: Английский

A stable and biocompatible shortwave infrared nanoribbon for dual-channel in vivo imaging DOI Creative Commons

Cheng Yao,

Ruwei Wei,

Xiao Luo

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 2, 2025

The shortwave infrared (SWIR) region is an ideal spectral window for next-generation bioimaging to harness improved penetration and reduced phototoxicity. SWIR activity may also be accessed via supramolecular dye aggregation. Unfortunately, development of aggregation remains challenging. We propose a crystal-aided aggregate synthesis (CAASH) approach introduce layer rationality the J-aggregate successful water-soluble JV-aggregate with bisbenzannulated silicon rhodamine scaffold (ESi5). resulting SWIR-aggregates exhibit excellent stabilities toward organic solvents, pH, sonication, photobleaching, thiols, endogenous oxidative species. Notably, aggregates have high structure-dependent melting temperature ca. 330-335 K. In fact, heating/annealing process can exploited reduce disorder. are biocompatible broad potential in vivo fluorescence photoacoustic imaging more. While has applications, stable absorbers/emitters challenging access. Here, authors report J-aggregates bioimaging.

Language: Английский

Citations

3
Biplane Ion‐Pairing Induced Supramolecular Assembly for High‐Performance Uranium Detection DOI
Zhen Su, Lixin Zhang, Huiqing Zhang

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

Abstract It is still challenging to directly recognize the anionic species [UO 2 (CO 3 ) ] 4− , dominant in environment (82%‐93%), using current optical probes because of adverse effects its thick hydration shell on binding interactions. In this study, a water‐soluble Pt(II) methylated terpyridine complex ([Pt(CH ‐tpy)NCO] + supramolecular probe designed target by new strategy overlapping arrangement. The response demonstrates excellent selectivity among ≈30 investigated interfering substances, along with rapid (≈15 s), high sensitivity (64.1 n m and dual‐signals. confirmed both experimentally theoretically that superior detection performance attributed formation unique structure featuring biplane‐like building block, bicolumnar stacking water‐bridged networks, via overlap shells aligned boost superentropic driving force, distinguishable dual‐signals arises from emergence four types Pt‐Pt interactions, generating low‐energy metal‐to‐metal charge transfer adsorption/emission. addition, [Pt(CH ‐based hydrogel platform constructed for detecting cationic uranium, limit 14.89 fg. This work unlocks not only way detect but also idea sensing ions extreme layers.

Language: Английский

Citations

1
Supra‐Fluorophores: Ultrabright Fluorescent Supramolecular Assemblies Derived from Conventional Fluorophores in Water DOI Creative Commons

Yuqing Lei,

Yuqian Wang, Sophie K. Hill

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(25)

Published: Feb. 28, 2024

Abstract Fluorescent organic nanoparticles (NPs) with exceptional brightness hold significant promise for demanding fluorescence bioimaging applications. Although considerable efforts are invested in developing novel dyes enhanced performance, augmenting the of conventional fluorophores is still one biggest challenges to overcome. This study presents a supramolecular strategy constructing ultrabright fluorescent aqueous media (referred as “Supra‐fluorophores”) derived from fluorophores. To achieve this, this course has employed cylindrical nanoparticle hydrophobic microdomain, assembled by cyclic peptide‐diblock copolymer conjugate water, scaffold. The noncovalent dispersion fluorophore moieties within microdomain scaffold effectively mitigates undesired aggregation‐caused quenching and resulting NPs high brightness. applicable broad spectrum families, covering polyaromatic hydrocarbons, coumarins, boron‐dipyrromethenes, cyanines, xanthenes, squaraines. demonstrate quantum yield (>30%) per volume (as 12 060 m −1 cm nm −3 ). Moreover, high‐performance emission NIR region constructed, showcasing up 20‐fold increase both photostability. Supra‐fluorophore offers versatile effective method transforming existing into environments, applications such bioimaging.

Language: Английский

Citations

8
Comprehensive Study of Artificial Light‐Harvesting Systems with a Multi‐Step Sequential Energy Transfer Mechanism DOI Creative Commons
Yong Wu, Yuqian Wang, Xu Yu

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(31)

Published: June 14, 2024

Abstract Artificial light‐harvesting systems (LHSs) with a multi‐step sequential energy transfer mechanism significantly enhance light utilization. Nonetheless, most of these exhibit an overall efficiency below 80%. Moreover, due to challenges in molecularly aligning multiple donor/acceptor chromophores, featuring ≥3‐step are rarely reported. Here, series artificial LHSs is introduced up 4‐step mechanism, constructed using cyclic peptide‐based supramolecular scaffold. These showed remarkably high efficiencies (≥90%) and satisfactory fluorescence quantum yields (ranging from 17.6% 58.4%). Furthermore, the structural robustness scaffold enables comprehensive study systems, elucidating associated pathways, identifying additional processes beyond targeted transfer. Overall, this investigation not only enhances understanding LHSs, but also underscores versatility scaffolds advancing harvesting technologies.

Language: Английский

Citations

8
Lego-like Visible Assembly of Responsive Components via Flexible Supramolecular Connectivity to Realize High-capacity Information Encoding DOI Creative Commons
Guiqiang Zhu, Qian Zhang,

Benwei Peng

et al.

Supramolecular Materials, Journal Year: 2025, Volume and Issue: unknown, P. 100099 - 100099

Published: Feb. 1, 2025

Language: Английский

Citations

1
GLUT1 as a generic biomarker enables near-infrared fluorescence molecular imaging guided precise intraoperative tumor detection in breast cancer DOI
Si-Qi Qiu,

Xiaofeng He,

Xiaolong Liang

et al.

European Journal of Nuclear Medicine and Molecular Imaging, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Language: Английский

Citations

0
Photo‐Triggered Fluorescence Polyelectrolyte Nanoassemblies: Manipulate and Boost Singlet Oxygen in Photodynamic Therapy DOI

Yongkang Yao,

Shangjun Chen, Chenxu Yan

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 10, 2024

Photodynamic therapy (PDT) is a clinically approved therapeutic modality that has shown great potential for cancer treatment. However, there exist two major problems hindering PDT applications: the nonspecific phototoxicity requiring patients to stay in dark post-PDT, and limited photodynamic efficiency. Herein, we report photo-triggered porphyrin polyelectrolyte nanoassembling (photo-triggered PPN) strategy, which photosensitizer photoswitchable energy accepter are assembled into micelles by combined force of charge interaction metal-ligand coordination. The polyelectrolyte-based PPN exhibits good biocompatibility, bestows unique "confining isolated" inner microenvironment fully overcoming π-π stacking porphyrins with significant efficiency (123-fold enhancement). Due high Förster resonance transfer (FRET) (91.5 %) between photoswitch closed-form, could use light as specific trigger modulate closed- open-form, manipulate

Language: Английский

Citations

2
Photo‐Triggered Fluorescence Polyelectrolyte Nanoassemblies: Manipulate and Boost Singlet Oxygen in Photodynamic Therapy DOI Open Access

Yongkang Yao,

Shangjun Chen, Chenxu Yan

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 10, 2024

Abstract Photodynamic therapy (PDT) is a clinically approved therapeutic modality that has shown great potential for cancer treatment. However, there exist two major problems hindering PDT applications: the nonspecific phototoxicity requiring patients to stay in dark post‐PDT, and limited photodynamic efficiency. Herein, we report photo‐triggered porphyrin polyelectrolyte nanoassembling (photo‐triggered PPN) strategy, which photosensitizer photoswitchable energy accepter are assembled into micelles by combined force of charge interaction metal‐ligand coordination. The polyelectrolyte‐based PPN exhibits good biocompatibility, bestows unique “confining isolated” inner microenvironment fully overcoming π–π stacking porphyrins with significant efficiency (123‐fold enhancement). Due high Förster resonance transfer (FRET) (91.5 %) between photoswitch closed‐form, could use light as specific trigger modulate closed‐ open‐form, manipulate 1 O 2 generation three stages: pre‐PDT (quenching generation), during (activating post‐PDT (silencing generation). This de novo strategy first time realized remotely manipulating boosting PDT, well resolving critical general challenges side effects from phototoxicity.

Language: Английский

Citations

0