Langmuir,
Journal Year:
2025,
Volume and Issue:
41(5), P. 3007 - 3026
Published: Jan. 31, 2025
Zwitterionic
hydrogels
have
emerged
as
a
highly
promising
class
of
biomaterials,
attracting
considerable
attention
due
to
their
unique
properties
and
diverse
biomedical
applications.
moieties,
with
balanced
positive
negative
charges,
endow
exceptional
hydration,
resistance
nonspecific
protein
adsorption,
low
immunogenicity
distinctive
molecular
structure.
These
facilitate
various
applications,
such
medical
device
coatings,
tissue
engineering,
drug
delivery,
biosensing.
This
review
explores
the
structure-property
relationships
in
zwitterionic
hydrogels,
highlighting
recent
advances
design
principles,
synthesis
methods,
structural
characteristics,
To
meet
evolving
growing
demand
for
field,
this
examines
current
challenges
future
research
directions
optimizing
multifunctional
hydrogels.
As
candidates
advanced
are
poised
address
critical
paving
way
improved
therapeutic
outcomes
broader
applicability
healthcare.
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Feb. 6, 2025
Neutrophil
extracellular
traps
(NETs)
participate
in
both
host
defense
and
the
pathogenesis
of
various
diseases,
such
as
infections,
thrombosis,
tumors.
While
they
help
capture
eliminate
pathogens,
NETs'
excessive
or
dysregulated
formation
can
lead
to
tissue
damage
disease
progression.
Therapeutic
strategies
targeting
NET
modulation
have
shown
potential,
but
challenges
remain,
particularly
achieving
precise
drug
delivery
maintaining
stability.
Nanoparticle
(NP)-based
systems
offer
innovative
solutions
for
overcoming
limitations
conventional
therapies.
This
review
explores
biological
mechanisms
formation,
their
interactions
with
NPs,
therapeutic
applications
NP-based
modulating
NETs.
We
discuss
how
NPs
be
designed
either
promote
inhibit
provide
a
comprehensive
analysis
potential
treating
NET-related
diseases.
Additionally,
we
address
current
future
prospects
therapies
research,
aiming
bridge
gap
between
nanotechnology
development
novel
approaches.
Effective
management
of
inflammation
is
one
the
promising
strategies
to
prevent
formation
chronic
wounds.
Despite
hydrogen
being
a
prospective
molecule
for
anti-inflammatory
effects,
on-demand
delivery
that
could
synchronize
with
dynamic
stages
has
yet
remained
unaddressed.
Moreover,
its
specific
immunomodulatory
mechanisms
are
still
veiled.
In
this
study,
we
introduced
ISO-ZIF-8@AB,
hydrogen-generating
nanoplatform
integrated
visible-light
photocatalysis
and
hydrolysis
reactions
achieve
controllable
release
on
demand,
functioning
an
initial
peak
following
sustained
release.
With
ISO-ZIF-8@AB
further
loaded
into
aligned
ECM-like
scaffold,
complex
significantly
alleviated
prevented
protracted
unhealing.
The
bulk-RNA
sequencing
combined
single-cell
RNA
revealed
treatment
effectively
reduced
excessive
aggregation
infiltration
innate
immune
cells.
Specifically,
proportion
Ptgs2+Nos2+
pro-inflammatory
macrophages
(PIMs)
by
mitigating
mitochondrial
stress
suppressing
HIF-1α-induced
glycolysis,
immune-metabolic
regulation
which
harmful
crosstalk
between
PIMs
hypodermal
fibroblasts
facilitated
extracellular
matrix
production
accompanied
ultimate
wound
repair.
Overall,
study
presented
strategy
in
terms
timing
rate,
discussions
regarding
underlying
therapy.
Autologous
platelet
concentrates
(APC)
represent
a
class
of
personalized
regenerative
materials
for
vascularized
tissue
regeneration.
However,
shortcomings
including
poor
controllability
gel
formation,
lack
reactive
oxygen
species
(ROS)
scavenging
ability,
and
deficient
anti-inflammatory
capacity
restrict
the
healing
outcomes
APC.
This
study
proposes
an
APC-based
synergistic
platform
(CurCDs@iPRF-MA)
treatment
chronic
wounds
in
diabetes.
Such
is
composed
injectable
platelet-rich
fibrin
(iPRF),
gelatin
methacryloyl
(GelMA),
carbogenic
nanodrug
from
curcumin
(CurCDs)
that
before
light-induced
formation
process,
greatly
facilitating
clinical
applications
Significantly,
CurCDs@iPRF-MA
can
modulate
mitochondrial
homeostasis
under
inflammatory
conditions,
activate
oxidative
phosphorylation
(OXPHOS)
program,
regulate
diabetic
microenvironment
through
metabolic
reprogramming
to
achieve
macrophage
phenotype
regulation
ROS
elimination,
as
well
promote
vascularization
by
releasing
autologous
growth
factors,
dramatically
improving
efficacy
offers
practical
effective
approach
developing
spatiotemporally
controllable
multifunctional
hydrogels
highly
