A cuproptosis-based nanomedicine suppresses triple negative breast cancers by regulating tumor microenvironment and eliminating cancer stem cells

Biomaterials, Journal Year: 2024, Volume and Issue: 313, P. 122763 - 122763

Published: Aug. 17, 2024

Language: Английский

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Biomolecule-based engineered nanoparticles for Cancer Theranostics

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 530, P. 216489 - 216489

Published: Feb. 3, 2025

Language: Английский

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Current roles of metals in arming sonodynamic cancer therapy

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 521, P. 216169 - 216169

Published: Aug. 24, 2024

Language: Английский

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“Crossbreeding” NIR‐II flavchromene for PSMA‐positive prostate cancer detection and image‐guided surgery

Smart Molecules, Journal Year: 2024, Volume and Issue: 2(3)

Published: July 4, 2024

Abstract Prostate‐specific membrane antigen (PSMA) is known to be overexpressed in prostate cancer (PCa). The development of precise and rapid imaging technologies monitor PSMA crucial for early diagnosis therapy. Fluorescence the second near‐infrared window (NIR‐II) has emerged as a powerful tool real‐time tracking vivo visualization, offering high sensitivity resolution. However, there lack stable, bright easy‐to‐implement NIR‐II fluorescent probes targeting. Herein, we presented PSMA‐targeting probe FC‐PSMA based on π‐conjugated crossbreeding dyed strategy that affords stability, large extinction coefficient, good brightness. As demonstrated, displayed fluorescence quantum yield fetal bovine serum (FBS). Following intravenous injection FC‐PSMA, tumor‐to‐normal ratio intensity steadily increased over time, reaching peak at 48 h (tumor‐to‐leg = 12.16 ± 0.90). This advancement enables identification PC through imaging, facilitating high‐performance guidance resection surgery.

Language: Английский

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Conversion of albumin into a BODIPY-like photosensitizer by a flick reaction, tumor accumulation and photodynamic therapy

Biomaterials, Journal Year: 2024, Volume and Issue: 313, P. 122792 - 122792

Published: Aug. 30, 2024

Language: Английский

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Hybridized and engineered microbe for catalytic generation of peroxynitrite and cancer immunotherapy under sonopiezo initiation

Science Advances, Journal Year: 2024, Volume and Issue: 10(44)

Published: Oct. 30, 2024

Living therapeutics is an emerging antitumor modality by living microorganisms capable of selective tropism and effective therapeutics. Nevertheless, primitive microbes could only present limited therapeutic functionalities against tumors. Hybridization the with multifunctional nanocatalysts great significance to achieve enhanced tumor catalytic therapy. In work, nitric oxide synthase (NOS)–engineered Escherichia coli strain MG1655 (NOBac) was used hybridize sonopiezocatalytic BaTiO 3 nanoparticles (BTO NPs) for efficient tumor-targeted accumulation Under ultrasound irradiation, superoxide anions created piezocatalytic reaction BTO NPs immediately react (NO) generated from NOBac produce highly oxidative peroxynitrite ONOO − species in cascade, resulting robust efficacy, prompting prominent sustained antitumoral immunoactivation simultaneously. The work presents a promising cancer immunotherapy based on engineered hybridized sonopiezo-controllable

Language: Английский

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Light/X-ray/ultrasound activated delayed photon emission of organic molecular probes for optical imaging: mechanisms, design strategies, and biomedical applications

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(22), P. 10970 - 11003

Published: Jan. 1, 2024

Versatile energy inputs, including light, X-ray and ultrasound, activate organic molecular probes to undergo different delay mechanisms, charge separation, triplet exciton stabilization chemical trap, for delayed photon emission.

Language: Английский

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Creating Single Atomic Coordination for Hypoxia‐Resistant Pyroptosis Nano‐Inducer to Boost Anti‐Tumor Immunotherapy

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 19, 2025

Abstract General synthesis and mechanical understanding of type I nano‐photosensitizers are great importance for hypoxia‐resistant pyroptosis inducers. Herein, a simple solvothermal treatment is developed to convert non‐photosensitive small molecules (hemin) into uniform carbon nanodots (HNCDs) with strong photodynamic activity red fluorescence emission. These HNCDs inherit the single atomic Fe–N 4 center hemin while creating sp 2 ‐hybridized surroundings, which synergistically modulated energy level electron transfer converting II process I. After encapsulating bovine serum albumin (BSA) facilitate in vivo applications, resulting BSA nanoparticles (HB) can image tumors significantly induce tumor cells even under an extremely hypoxic environment (2% O ). This evokes antitumor immune response, effectively restraining growth lung metastasis triple‐negative breast cancer mice, good biocompatibility. work introduces applicable nano‐inducer combat highlights regulation centers develop treatment.

Language: Английский

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ATP‐Triggered Ultrafine Iron Oxide Nanowires for Self‐Monitoring Tumor Therapy by T₁‐Magnetic Resonance Imaging‐Guided •OH Generation

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 13, 2025

Abstract Theranostic probes that integrate diagnosis and treatment together are considered as effective tools for individual therapy. However, the separation of detection components limits precise assessment therapeutic efficacy. Herein, a novel self‐monitoring probe sensitively responds to adenosine triphosphate (ATP) was developed by ultrafine iron oxide nanowires (UIONWs) through an oleyl amine‐assisted way. The UIONWs, with diameter 1.5 nm length 75 nm, surface‐coordinated amine. UIONWs can be decomposed in ATP‐containing solution expose shielded ions. Consequently, it boost peroxidase (POD) activity activate T 1 ‐magnetic resonance imaging (MRI) signal ATP. In addition, rapidly engulfed into cells due high aspect ratio. improved ATP hydrogen peroxide (H 2 O ) within tumor leads higher hydroxyl radicals (OH) generation inhibition.In contrast, normal exhibit lower H levels, reducing cytotoxicity ensuring safety. Since both illumination ‐MRI OH ATP‐controlled, this work raised potential way self‐monitor therapy timely feedback on effects.

Language: Английский

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Vascular Magnifier for Ultrahigh-Resolution Visualization of Cerebral Vessels in Vivo

Biomaterials, Journal Year: 2025, Volume and Issue: 322, P. 123356 - 123356

Published: April 24, 2025

Language: Английский

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