Photo‐Triggered Fluorescence Polyelectrolyte Nanoassemblies: Manipulate and Boost Singlet Oxygen in Photodynamic Therapy DOI

Yongkang Yao,

Shangjun Chen, Chenxu Yan

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 10, 2024

Photodynamic therapy (PDT) is a clinically approved therapeutic modality that has shown great potential for cancer treatment. However, there exist two major problems hindering PDT applications: the nonspecific phototoxicity requiring patients to stay in dark post-PDT, and limited photodynamic efficiency. Herein, we report photo-triggered porphyrin polyelectrolyte nanoassembling (photo-triggered PPN) strategy, which photosensitizer photoswitchable energy accepter are assembled into micelles by combined force of charge interaction metal-ligand coordination. The polyelectrolyte-based PPN exhibits good biocompatibility, bestows unique "confining isolated" inner microenvironment fully overcoming π-π stacking porphyrins with significant efficiency (123-fold enhancement). Due high Förster resonance transfer (FRET) (91.5 %) between photoswitch closed-form, could use light as specific trigger modulate closed- open-form, manipulate

Language: Английский

Small Organic Molecules-based NIR Agents in Cancer Diagnostics: New Frontiers in Imaging and Therapy DOI

Dr Amal Adnan Ashour,

Mohammed Fareed Felemban,

Dr Faris J. Tayeb

et al.

Dyes and Pigments, Journal Year: 2025, Volume and Issue: unknown, P. 112648 - 112648

Published: Jan. 1, 2025

Language: Английский

Citations

0
Development of fluorescent probe for specific recognition of chiral alanine DOI
Zhida Han,

Shijun Chen,

Yuwei Wu

et al.

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2025, Volume and Issue: unknown, P. 126155 - 126155

Published: April 1, 2025

Language: Английский

Citations

0
Computational chemistry facilitates the development of second near-infrared xanthene-based dyes DOI
Qiupeng Yuan, Mingyu Wang, Mingyue Ma

et al.

Journal of Molecular Modeling, Journal Year: 2024, Volume and Issue: 30(11)

Published: Oct. 29, 2024

Language: Английский

Citations

2
Fluorescent probes for the visualization of membrane microdomain, deformation, and fusion DOI Creative Commons
Peihong Tong,

Tung-Kung Wu,

Mingle Li

et al.

Smart Molecules, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 30, 2024

Abstract The cell membrane, a fluid interface composed of self‐assembled phospholipid molecules, is vital component biological systems that maintains cellular stability and prevents the invasion foreign toxins. Due to its inherent fluidity, membrane can undergo bending, shearing, stretching, making deformation crucial in processes like adhesion, migration, phagocytosis, signal transduction. Within plasma are highly ordered dynamic structures formed by lipid known as “lipid rafts,” whose dissociation reorganization prerequisites for deformation. Fluorescent probes have emerged tools studying these processes, offering non‐destructive, situ, real‐time imaging method. By strategically designing probes, researchers image not only microdomains membranes but also explore more complex such fusion fission. This review systematically summarizes latest advancements application fluorescent imaging. It discusses current challenges provides insights into future research directions. We hope this inspires further studies on using ultimately advancing our understanding mechanisms underlying dissociation, reorganization, fusion, separation, fostering therapeutic development membrane‐associated diseases.

Language: Английский

Citations

1
Delayed Fluorescence Materials: Mechanism, Design, and Bioapplication DOI

Lixun Zhu,

Zicong Zhang, Yanling Liu

et al.

The Journal of Physical Chemistry C, Journal Year: 2024, Volume and Issue: 128(38), P. 15763 - 15777

Published: Sept. 17, 2024

Language: Английский

Citations

0
Photo‐Triggered Fluorescence Polyelectrolyte Nanoassemblies: Manipulate and Boost Singlet Oxygen in Photodynamic Therapy DOI Open Access

Yongkang Yao,

Shangjun Chen, Chenxu Yan

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 10, 2024

Abstract Photodynamic therapy (PDT) is a clinically approved therapeutic modality that has shown great potential for cancer treatment. However, there exist two major problems hindering PDT applications: the nonspecific phototoxicity requiring patients to stay in dark post‐PDT, and limited photodynamic efficiency. Herein, we report photo‐triggered porphyrin polyelectrolyte nanoassembling (photo‐triggered PPN) strategy, which photosensitizer photoswitchable energy accepter are assembled into micelles by combined force of charge interaction metal‐ligand coordination. The polyelectrolyte‐based PPN exhibits good biocompatibility, bestows unique “confining isolated” inner microenvironment fully overcoming π–π stacking porphyrins with significant efficiency (123‐fold enhancement). Due high Förster resonance transfer (FRET) (91.5 %) between photoswitch closed‐form, could use light as specific trigger modulate closed‐ open‐form, manipulate 1 O 2 generation three stages: pre‐PDT (quenching generation), during (activating post‐PDT (silencing generation). This de novo strategy first time realized remotely manipulating boosting PDT, well resolving critical general challenges side effects from phototoxicity.

Language: Английский

Citations

0
Photo‐Triggered Fluorescence Polyelectrolyte Nanoassemblies: Manipulate and Boost Singlet Oxygen in Photodynamic Therapy DOI

Yongkang Yao,

Shangjun Chen, Chenxu Yan

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 10, 2024

Photodynamic therapy (PDT) is a clinically approved therapeutic modality that has shown great potential for cancer treatment. However, there exist two major problems hindering PDT applications: the nonspecific phototoxicity requiring patients to stay in dark post-PDT, and limited photodynamic efficiency. Herein, we report photo-triggered porphyrin polyelectrolyte nanoassembling (photo-triggered PPN) strategy, which photosensitizer photoswitchable energy accepter are assembled into micelles by combined force of charge interaction metal-ligand coordination. The polyelectrolyte-based PPN exhibits good biocompatibility, bestows unique "confining isolated" inner microenvironment fully overcoming π-π stacking porphyrins with significant efficiency (123-fold enhancement). Due high Förster resonance transfer (FRET) (91.5 %) between photoswitch closed-form, could use light as specific trigger modulate closed- open-form, manipulate

Language: Английский

Citations

0