Photodynamic Therapy in Cancer: Insights into Cellular and Molecular Pathways

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(2), P. 69 - 69

Published: Jan. 21, 2025

Photodynamic therapy is a non-ionizing radiation treatment that utilizes photosensitizer in combination with light to produce singlet oxygen. This oxygen induces anti-cancer effects by causing apoptotic, necrotic, or autophagic cell death tumor cells. Currently, photodynamic employed oncology treat various cancers. In the presence of oxygen, this non-invasive approach leads direct death, damage microvasculature, and induction local inflammatory response. These allow be effective treating early-stage tumors, extending survival cases where surgery not feasible, significantly improving quality life. paper, we provide state art on cytomolecular mechanisms associated pathways involved therapy. By integrating these mechanistic insights most recent advancements nanotechnology, phototherapeutic has potential become prevalent option within conventional cancer therapies, enhancing its application precision medicine.

Language: Английский

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An AIE-active Janus filter membrane for highly efficient detection and elimination of bioaerosols

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 492, P. 138116 - 138116

Published: April 2, 2025

Language: Английский

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Pyrrolopyrrole Cyanine-Based Polymer with Superior Multifunctionality for Boosting Cancer Phototheranostics

ACS Materials Letters, Journal Year: 2025, Volume and Issue: unknown, P. 1431 - 1439

Published: March 19, 2025

Molecular agents with exceptional multifunctionality are highly sought for phototheranostic applications. Herein we present a high-performance polymer near-infrared II (NIR-II) fluorescence and photoacoustic (PA) imaging-guided mild photothermal therapy (mPTT) of tumors. We synthesize series semiconducting polymers based on pyrrolopyrrole cyanine, identifying that P(P-T) exhibits large mass extinction coefficient (139 L g–1 cm–1), excellent performance, bright NIR-II fluorescence, PA imaging signals, making it among the highest-performing in these properties. A tumor-targeting agent was developed by coencapsulating heat shock protein (HSP) inhibitor camouflaging M1 macrophage membranes. The integration enables comprehensive tumor site delineation, guiding subsequent therapeutic intervention. In 4T1 tumor-bearing mice, synergistic effect mPTT under low-power 808 nm laser irradiation, combined HSP inhibition, resulted significant suppression. This work offers valuable insights designing advanced agents.

Language: Английский

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Illuminating oral health: AIEgens for phototheranostics

Published: March 1, 2025

Language: Английский

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Endoplasmic Reticulum-Targeted Phototherapy Remodels the Tumor Immunopeptidome to Enhance Immunogenic Cell Death and Adaptive Anti-Tumor Immunity

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(4), P. 491 - 491

Published: March 28, 2025

Background: Endoplasmic reticulum (ER)-targeted phototherapy has emerged as a promising approach to amplify ER stress, induce immunogenic cell death (ICD), and enhance anti-tumor immunity. However, its impact on the antigenicity of dying tumor cells remains poorly understood. Methods: Laser activation ER-targeted photosensitizer ER-Cy-poNO2 was performed investigate effects antigenicity. Transcriptomic analysis carried out assess gene expression changes. Immunopeptidomics profiling used identify high-affinity major histocompatibility complex class I (MHC-I) ligands. In vitro functional studies were conducted evaluate dendritic maturation T lymphocyte activation, while in vivo experiments by combining identified peptide with poly IC Results: significantly remodeled antigenic landscape 4T-1 cells, enhancing their immunogenicity. revealed upregulation antigen processing presentation pathways. multiple MHC-I ligands, IF4G3986–994 (QGPKTIEQI) showing exceptional vitro, promoted enhanced lymphocytes activation. vivo, combination elicited robust immunity, characterized increased CD8+ infiltration, reduced regulatory (Tregs) microenvironment, elevated systemic Interferon-gamma (IFN-γ) levels, significant growth inhibition without toxicity. Conclusions: These findings establish mechanistic link between stress-driven ICD, immunopeptidome remodeling, adaptive immune highlighting potential platform for identifying peptides advancing peptide-based cancer vaccines.

Language: Английский

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The synthesis, photophysical and biological properties of 5,10,15,20-tetra(4-substituted phenyl)tetrabenzoporphyrin derivatives

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 117612 - 117612

Published: April 1, 2025

Language: Английский

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Growth of NIR-II-Responsive Gold Nanobipyramids with Improved Yield and a Study of Their Application in Cancer Therapy

Langmuir, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Gold nanobipyramids (Au NBPs), as a novel and emerging plasmonic nanomaterial, have shown larger local electric field enhancements, optical cross-sections, higher refractive index sensitivity compared to other nanoparticles. Besides, their localized surface plasmon resonance (LSPR) absorption can be tailored cover the entire NIR-II light region, which is crucial for clinical cancer treatment. However, strategies synthesize Au NBPs with an response still several disadvantages, such tedious procedures use of hazardous chemical substances. In this work, we used seed-mediated growth method explored new high-yield response, especially in region above 1030 nm, by regulating conditions during seed growth. The yield at 1060 nm has been improved 5-fold 6-fold previous methods when 230 μL sodium citrate or controlled temperature 45 °C were solution containing 125 NaBH4. influence mechanism these factors on detail. Furthermore, photodynamic photothermal behaviors LSPR investigated, results indicate that great potential therapy. proven induce immunogenic cell death (ICD), indicating immunotherapy. This work may provide idea synthesis biomedical applications response.

Language: Английский

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Bioengineered nanomaterials for dynamic diagnostics in vivo

Chemical Society Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

By integrating four energy modalities—NIR light, radiation, magnetic field, and ultrasound—with bioengineered nanomaterials, dynamic in vivo diagnostics can be achieved, advancing the path toward personalized precision medicine.

Language: Английский

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Photoinduced Proton-Transfer-Mediated Molecular Recognition in Molecular Crystals

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

Molecular recognition has traditionally been focused on ground-state interactions. However, leveraging photoenergy to access excited-state molecular recognition, which may enable enhanced sensitivity or selectivity that is unattainable in the ground state, remains underexplored. In this study, we demonstrate a novel photoinduced mechanism using self-assembled crystalline microribbons composed of donor-acceptor (D-A) molecule with twisted backbone for ultratrace phenol vapor detection. We confirm proton transfer occurs from C═N group pyridine moiety D-A system, generating protonated and phenoxide ion triggers fluorescence quenching. This proton-transfer-mediated endows exceptional toward vapor, achieving limit detection (LOD) 0.6 parts per trillion (ppt). Our findings reveal harnessing light energy drive opens new avenues advancing sensing technologies.

Language: Английский

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Phototheranostics: An Advanced Approach for Precise Diagnosis and Treatment of Gynecological Inflammation and Tumors

Biomaterials, Journal Year: 2024, Volume and Issue: 316, P. 123012 - 123012

Published: Dec. 15, 2024

Language: Английский

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