Advanced Therapeutics,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 18, 2024
Abstract
Myocardial
infarction
(MI)
remains
the
leading
cause
of
death
in
patients
with
cardiovascular
disease
worldwide,
therapeutic
approaches
predominantly
relying
on
medication,
medical
device
implantation,
and
organ
transplantation,
each
constrained
by
inherent
limitations.
Injectable
hydrogels
have
recently
emerged
as
promising
tools,
noted
for
their
biocompatibility,
injectability,
capacity
to
provide
mechanical
support
crucial
myocardial
tissue
repair.
This
review
aims
comprehensively
explore
interaction
between
injectable
repair
post‐infarction.
It
encompasses
recent
advancements
various
types
used
MI
therapy,
including
those
modulating
microenvironments,
conducting
electricity,
influencing
immunomodulation,
promoting
angiogenesis,
improving
ischemia‐reperfusion
conditions.
By
synthesizing
current
research
findings,
this
facilitates
interdisciplinary
knowledge
integration
development
effective
prognostic
indicators
materials.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: May 31, 2024
Myocardial
infarction
(MI)
stands
as
a
prominent
contributor
to
global
cardiovascular
disease
(CVD)
mortality
rates.
Acute
MI
(AMI)
can
result
in
the
loss
of
large
number
cardiomyocytes
(CMs),
which
adult
heart
struggles
replenish
due
its
limited
regenerative
capacity.
Consequently,
this
deficit
CMs
often
precipitates
severe
complications
such
failure
(HF),
with
whole
transplantation
remaining
sole
definitive
treatment
option,
albeit
constrained
by
inherent
limitations.
In
response
these
challenges,
integration
bio-functional
materials
within
cardiac
tissue
engineering
has
emerged
groundbreaking
approach
significant
potential
for
replacement.
Bioengineering
strategies
entail
fortifying
or
substituting
biological
tissues
through
orchestrated
interplay
cells,
methodologies,
and
innovative
materials.
Biomaterial
scaffolds,
crucial
paradigm,
provide
essential
microenvironment
conducive
assembly
functional
encapsulating
contracting
cells.
Indeed,
field
witnessed
remarkable
strides,
largely
owing
application
biomaterial
scaffolds.
However,
complexities
persist,
necessitating
further
exploration
innovation.
This
review
delves
into
pivotal
role
scaffolds
engineering,
shedding
light
on
their
utilization,
challenges
encountered,
promising
avenues
future
advancement.
By
critically
examining
current
landscape,
we
aim
catalyze
progress
toward
more
effective
solutions
regeneration
ultimately,
improved
outcomes
patients
grappling
ailments.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 23, 2024
Abstract
Conductive
hydrogels
combine
the
benefits
of
soft
with
electrical
conductivity
and
have
gained
significant
attention
over
past
decade.
These
innovative
materials,
including
poly(3,4‐ethylenedioxythiophene)
(PEDOTs)‐based
conductive
(P‐CHs),
are
promising
for
flexible
electronics
biological
applications
due
to
their
tunable
flexibility,
biocompatibility,
hydrophilicity.
Despite
recent
advances,
intrinsic
correlation
between
design,
fabrications,
P‐CHs
has
been
mostly
based
on
trial‐and‐error‐based
Edisonian
approaches,
significantly
limiting
further
development.
This
review
comprehensively
examines
design
strategies,
fabrication
technologies,
diverse
P‐CHs.
By
summarizing
such
as
molecular,
network,
phase,
structural
engineering,
exploring
both
2D
3D
techniques,
this
offers
a
comprehensive
overview
in
fields
bioelectronics,
actuators,
energy
devices,
solar
evaporators.
Establishing
critical
internal
connection
fabrication,
application
aims
guide
future
research
stimulate
innovation
field
functional
P‐CHs,
offering
broad
multidisciplinary
researchers.
Journal of Polymer Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 6, 2025
ABSTRACT
PEDOT:PSS
is
a
widely
applied
material
in
the
field
of
organic
electronics.
Due
to
its
mixed
ionic‐electronic
conductivity,
it
popular
for
soft
actuators
based
on
stimulated
ion
exchange.
However,
confined
spaces
like
thin
films,
interfaces
play
an
important
role
actuation.
Hence,
we
studied
actuation
behavior
films
with
film
thicknesses
ranging
from
100
nm
up
3
μm
by
atomic
force
microscopy.
We
observed
decrease
relative
expansion
thicker
films.
Moreover,
volume
charge
density
also
decreased.
Electrochemical
impedance
spectroscopy
granted
more
insight
into
charging.
significant
differences
between
oxidized
and
reduced
described
diffusion
pseudo‐capacitance,
which
decreased
conclude
limitation
affects
charging
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 30, 2025
Mechanical
mismatches
at
the
microscale
between
bioelectronics
and
cells
severely
hinder
successful
acquisition
of
high-quality
stable
electrophysiological
signals.
Room-temperature
liquid
metals
(EGaIn),
which
possess
a
near-zero
Young's
modulus,
present
promising
material
for
achieving
conformal
contact
with
biological
tissues.
However,
fluidity
limits
elastic
encapsulation
patterned
circuits
cellular
resolution.
To
address
this
challenge,
we
develop
bilayer
microfluidics-based
method
to
elastically
encapsulate
high-resolution
electrode
array
(20
μm)
within
several
minutes
(<3
min).
The
alignment-free
overcomes
limitations
packaging
polymers
aligners,
enabling
cost-effective,
scalable
manufacturing
devices.
These
electronics
exhibit
excellent
wear
resistance,
high
flexibility
(>300%
strain),
biocompatibility,
facilitating
long-term
interfacing
cardiomyocytes
collection
(∼30
dB)
cell
field
potential
signals
as
well
epicardial
(∼42
from
living
rat
models.
This
rapid
straightforward
approach
improves
precision
integration
metal-based
flexible
electronics,
holding
promise
monitoring
treatment,
such
mapping,
electrical
stimulation,
other
therapeutic
interventions
levels.
Expert Opinion on Drug Delivery,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 25, 2024
Myocardial
infarction
(MI)
causes
extensive
structural
and
functional
damage
to
the
cardiac
tissue
due
significant
loss
of
cardiomyocytes.
Early
reperfusion
is
standard
treatment
strategy
for
acute
MI,
but
it
associated
with
adverse
effects.
Additionally,
current
therapies
alleviate
pathological
changes
post-MI
are
not
effective.
Subsequent
remodeling
damaged
myocardium
often
results
in
heart
failure.
Oral
drugs
aimed
at
reducing
myocardial
require
repeated
administration
high
doses
maintain
therapeutic
levels.
This
compromises
efficacy
patient
adherence
may
cause
effects,
such
as
hypotension
liver
and/or
kidney
dysfunction.
Hydrogels
have
emerged
an
effective
delivery
platform
orthotopic
MI
their
water
content
excellent
compatibility.
Macromolecular Rapid Communications,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 13, 2025
Abstract
Myocardial
infarction
(MI)
is
a
leading
cause
of
mortality
among
cardiovascular
diseases.
Following
MI,
the
damaged
myocardium
progressively
being
replaced
by
fibrous
scar
tissue,
which
exhibits
poor
electrical
conductivity,
ultimately
resulting
in
arrhythmias
and
adverse
cardiac
remodeling.
Due
to
their
extracellular
matrix‐like
structure
excellent
biocompatibility,
hydrogels
are
emerging
as
focal
point
tissue
engineering.
However,
traditional
lack
necessary
conductivity
restore
signal
transmission
infarcted
regions.
Imparting
while
also
enhancing
adhesive
properties
enables
them
adhere
closely
myocardial
establish
stable
connections,
facilitate
synchronized
contraction
repair
within
area.
This
paper
reviews
strategies
for
constructing
conductive
hydrogels,
focusing
on
application
MI
repair.
Furthermore,
challenges
future
directions
developing
discussed.
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 5, 2025
Poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate)
(PEDOT:PSS)
hydrogel
are
promising
for
applications
in
electromagnetic
interference
(EMI)
shielding,
energy
storage,
and
electrochromic
(EC)
devices.
However,
challenges
such
as
low
conductivity
at
reduced
solid
content,
limited
charge
poor
mechanical
properties,
structural
distortion
during
solvent
treatment
limit
their
high-performance
applications.
To
address
these
issues,
a
high-fidelity,
high-conductivity
multifunctional
PEDOT:PSS
is
developed
by
an
ice
crystal-assisted
skeleton
stacking
stepwise
strategy,
achieving
ultrahigh
of
87,249
S
m-1
5.8
wt%
content.
The
also
features
storage
capacity
35.66
mC
cm-2
capacitance
density
587.6
mF
cm-2.
Additionally,
demonstrates
exceptional
EMI
shielding
effectiveness,
81.2
dB,
exhibits
specific
surface
efficiency
30,769.23
dB
cm2
g-1.
Notably,
maintains
high
stability
even
after
undergoing
various
harsh
conditions.
Using
femtosecond
laser
direct
writing,
the
highly
stable
all-solid-state
EC
reflective
displays
with
ultrafast
response
(<0.3
s)
superior
durability.
