Advanced Therapeutics,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 18, 2024
Abstract
Myocardial
infarction
(MI)
remains
the
leading
cause
of
death
in
patients
with
cardiovascular
disease
worldwide,
therapeutic
approaches
predominantly
relying
on
medication,
medical
device
implantation,
and
organ
transplantation,
each
constrained
by
inherent
limitations.
Injectable
hydrogels
have
recently
emerged
as
promising
tools,
noted
for
their
biocompatibility,
injectability,
capacity
to
provide
mechanical
support
crucial
myocardial
tissue
repair.
This
review
aims
comprehensively
explore
interaction
between
injectable
repair
post‐infarction.
It
encompasses
recent
advancements
various
types
used
MI
therapy,
including
those
modulating
microenvironments,
conducting
electricity,
influencing
immunomodulation,
promoting
angiogenesis,
improving
ischemia‐reperfusion
conditions.
By
synthesizing
current
research
findings,
this
facilitates
interdisciplinary
knowledge
integration
development
effective
prognostic
indicators
materials.
MedComm,
Journal Year:
2025,
Volume and Issue:
6(5)
Published: April 24, 2025
ABSTRACT
Hydrogels
have
emerged
as
dependable
candidates
for
tissue
repair
because
of
their
exceptional
biocompatibility
and
tunable
mechanical
properties.
However,
conventional
hydrogels
are
vulnerable
to
damage
owing
stress
environmental
factors
that
compromise
structural
integrity
reduce
lifespan.
In
contrast,
self‐healing
with
inherent
ability
restore
structure
function
autonomously
offer
prolonged
efficacy
enhanced
appeal.
These
can
be
engineered
into
innovative
forms
including
stimulus‐responsive,
self‐degradable,
injectable,
drug‐loaded
variants,
thereby
enhancing
applicability
in
wound
healing,
drug
delivery,
engineering.
This
review
summarizes
the
categories
mechanisms
hydrogels,
along
biomedical
applications,
repair,
biosensing.
Tissue
includes
bone‐related
nerve
cardiac
repair.
Additionally,
we
explored
challenges
continue
face
presented
a
forward‐looking
perspective
on
development.
Consequently,
it
is
anticipated
will
progressively
designed
developed
applications
extend
beyond
broader
range
applications.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 14, 2025
Abstract
Electroactive
platforms
have
gained
significant
attention
for
their
ability
to
convert
various
types
of
energy
into
electrical
signals,
offering
promising
applications
in
diverse
biomedical
fields.
In
cardiovascular
care,
these
are
increasingly
valued
innovative
solutions
managing
cardiac
functions
and
disorders.
By
regulating
activity
the
heart,
electroactive
offer
novel
methods
abnormal
heart
rhythms.
This
review
explores
latest
advancements
systems,
categorizing
them
based
on
sources
mechanisms,
such
as
self‐powered
conductive
systems.
It
also
highlights
arrhythmia
management,
including
monitoring,
intervention,
pacing,
repairing.
Finally,
challenges,
limitations,
future
opportunities
clinical
translation
technologies
discussed.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 27, 2025
Tissue
engineering
enables
the
production
of
tissues
and
organ-like
structures
as
models
for
drug
testing
mechanistical
studies
or
functional
replacements
injured
tissues.
Available
cytocompatible
materials
are
limited
in
number,
suffer
from
insufficient
mechanical
properties,
cells
interacting
with
them
often
cause
construct
shrinkage.
As
shape
is
important
function,
identifying
cytocompatible,
shrink-resistant
a
major
aim.
Here,
it
shown
that
hydrogels
made
interpenetrating
networks
collagen-I
recombinant
spider
silk
protein
eADF4(C16)-RGD
nanofibrils
exhibit
synergistic
tunable
properties.
Composite
allow
cell
adhesion
spreading
resistant
to
shrinkage
mediated
by
fibroblasts,
C2C12
myoblasts,
human
induced
pluripotent
stem
(hiPSC)-derived
cardiomyocytes.
Myoblasts
differentiate
fuse
into
myotubes,
hiPSC-cardiomyocytes
can
be
cultured
long-term,
show
spontaneous
contractions,
remain
responsive.
Collectively,
novel
composite
material
developed
overcome
challenge
post-fabrication
matrix
conferring
high
fidelity
suitable
tissue
engineering.
Macromolecular Materials and Engineering,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 7, 2025
Abstract
Conductive
hydrogels
are
a
potential
platform
for
3D
cell
culture,
especially
in
bioelectronic
interfaces,
enabling
the
integration
of
electronic
and
mechanical
signals
as
biological
cues.
Biopolymer‐based
conductive
offer
significant
advantages
thanks
to
their
inherent
flexibility
renewable
biocompatible
properties,
combination
with
conductivity
hydrogel
network.
However,
hydrogels'
vulnerability
failure
limits
durability
applications.
To
address
this,
self‐healing
reversible
dynamic
networks
have
emerged.
These
materials
capable
repairing
themselves
after
damage
closely
mimic
healing
characteristics
living
tissues.
This
capability
thus
promotes
reliable
long‐lasting
use
devices.
review
first
examines
individual
hydrogels,
namely
electrical
from
conjugated
polymer
cues
biopolymer,
terms
influence
on
cellular
activities.
Subsequently,
recent
advancements
biopolymer‐based
discussed,
focus
fabrication
method
ability
modulate
specific
functions.
Finally,
bioelectronics
summarized,
focusing
variety
mechanisms
corollaries
enhanced
longevity.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(9), P. 4009 - 4009
Published: April 24, 2025
Tissue
engineering
techniques
aim
to
improve
or
replace
biological
tissues
organs
by
utilizing
the
extracellular
matrix
facilitate
repair
of
damaged
organs.
Collagen-based
scaffolds
offer
numerous
advantages,
including
excellent
biocompatibility,
low
immunogenicity,
biodegradability,
hemostatic
properties,
and
mechanical
strength.
Collagen
can
reconstruct
microenvironment,
promote
cell
adhesion,
migration,
proliferation,
differentiation,
play
a
critical
role
in
cell-to-cell
cell-to-matrix
interactions.
has
been
extensively
utilized
tissue
organ
reconstruction.
This
review
examines
properties
collagen,
its
composition,
structure,
characteristics,
regulating
various
cellular
behaviors.
Additionally,
preparation
cell-loaded
collagen
is
discussed,
along
with
comprehensive
overview
their
applications
tissues,
skin,
nerve,
bone/cartilage,
heart,
liver,
others.
Emerging
strategies
future
perspectives
for
clinical
are
also
presented.
provides
synthesis
mechanisms
underlying
use
as
advanced
biomaterials,
emphasizing
potential
expand
collagen.
Small Science,
Journal Year:
2024,
Volume and Issue:
4(11)
Published: Aug. 7, 2024
Thermoelectric
materials'
unique
merits
attract
considerable
attention.
Among
those
merits,
the
straight
transformation
between
heat
and
electricity
makes
this
material
potential.
The
energy
of
human
body
is
released
in
form
heat,
which
can
be
transformed
into
effective
by
wearable
thermoelectric
materials.
nanotechnology-based
materials
improve
properties
absorption
abilities
for
nanostructures
will
help
maintain
good
electrical
conductivity
reduce
thermal
conductivity.
Poly(3,4-ethylenedioxythiophene)
(PEDOT)
extensively
investigated
its
high
conductivity,
flexibility,
transparency,
so
on.
This
article
reviews
mechanism
describes
preparation
techniques
PEDOT,
inorganic
semiconductor
composite,
low-dimensional
metal
composite
recent
research
progress
on
PEDOT-based
materials,
application
methods
to
performance
device
design,
commercialization
are
specifically
discussed.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 8, 2024
Electrical
stimulation
has
been
hotpot
research
and
provoked
extensive
interest
in
a
broad
application
such
as
wound
closure,
tissue
injury
repair,
nerve
engineering.
In
particular,
immense
efforts
have
dedicated
to
developing
electrical
microneedles,
which
demonstrate
unique
features
terms
of
controllable
drug
release,
real-time
monitoring,
therapy,
thus
greatly
accelerating
the
process
healing.
Here,
review
state-of-art
concerning
microneedles
applied
for
treatment
is
presented.
After
comprehensive
analysis
mechanisms
on
healing,
derived
three
types
are
clarified
summarized.
Further,
their
applications
healing
highlighted.
Finally,
current
perspectives
directions
development
future
improving
addressed.
