Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 20, 2024
Abstract
Radiotherapy‐induced
ferroptosis
is
accompanied
by
an
adaptive
response
to
the
expression
of
tumor
cell
suppressor
genes.
Herein,
a
degradable
and
in
situ
generated
silicomanganese
composite
system
loaded
with
carbonic
anhydrase
(CA
IX)
inhibitor
(4‐(2‐aminoethyl)
benzenesulfonamide
(ABS)
constructed
form
DSiMn‐ABS
nanosystem
improve
sensitivity
hypoxic
cells
radiotherapy
effect.
The
can
be
continuously
degraded
environment
X‐rays,
releasing
Manganese
dioxid
（MnO
2
)and
ABS;
Thereby
inhibiting
activity
CA
IX,
inducing
acidification
inside
cells,
regulating
AMP‐activating
protein
kinase
(AMPK)/Acetyl‐CoA
carboxylase(ACC)
axis
increase
ferroptosis,
depleting
glutathione
(GSH)
through
MnO
influencing
peroxidase
4
(GPX4)
activity,
which
further
inhibits
defense
ultimately
effectively
improves
therapeutic
efficiency
radiotherapy.
Ultimately,
inhibit
growth.
Therefore,
this
utilize
double‐sensitized
provide
new
ideas
for
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Oct. 8, 2024
In
diabetic
wounds,
hyperglycemia-induced
cytotoxicity
and
impaired
immune
microenvironment
plasticity
directly
hinder
the
wound
healing
process.
Regulation
of
hyperglycemic
remodeling
are
crucial.
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 10, 2025
Abstract
X‐ray
induced
photodynamic
therapy
(X‐PDT)
leverages
penetrating
to
generate
singlet
oxygen
(
1
O
2
)
for
treating
deep‐seated
tumors.
However,
conventional
X‐PDT
typically
relies
on
heavy
metal
inorganic
scintillators
and
organic
photosensitizers
produce
,
which
presents
challenges
related
toxicity
energy
conversion
efficiency.
In
this
study,
highly
biocompatible
phosphorescent
nanoscintillators
based
hydrogen‐bonded
frameworks
(HOF)
are
designed
engineered,
termed
BPT‐HOF@PEG,
enhance
in
hepatocellular
carcinoma
(HCC)
treatment.
BPT‐HOF@PEG
functions
simultaneously
as
both
scintillator
photosensitizer,
effectively
absorbing
transferring
abundant
.
Both
vitro
vivo
investigations
demonstrate
that
internalized
efficiently
produces
significant
quantities
of
upon
irradiation.
Additionally,
exposure
directly
inflicts
DNA
damage,
the
synergistic
effects
these
mechanisms
result
pronounced
cell
death
substantial
tumor
growth
inhibition,
with
a
inhibition
rate
up
90.4%
assessments.
RNA
sequencing
analyses
reveal
induces
apoptosis
Hepa1‐6
cells
while
inhibiting
proliferation,
culminating
death.
Therefore,
work
highlights
considerable
potential
efficient
HOF
nanoscintillators‐based
promising
therapeutic
approach
HCC,
providing
effective
alternative
negligible
patients
unresectable
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 31, 2025
Abstract
Targeted
delivery
of
glucose
oxidase
(GOx)
using
MXene
remains
a
great
challenge
due
to
its
poor
dispersion
and
susceptibility
oxidation,
the
hypoxia
high
glutathione
(GSH)
contents
make
situation
even
more
worrying.
Herein,
bovine
serum
albumin‐mediated
non‐chemical
modification
strategy
is
developed,
endowing
titanium
carbide
with
long‐time
water‐dispersion
further
integrating
it
as
glycolysis‐controllable
therapy
system
without
any
chemotherapeutic
agents.
The
also
constructs
an
effective
O
2
cycling
GSH
degradation
pathway,
which
fundamentally
adjusts
tumor
microenvironment
greatly
elevates
both
in
vivo
vitro
effects.
Reactive
oxygen
species
are
generated
disrupt
balance
oxidative
stress.
Moreover,
reduced
efficiency
mitochondrial
energy
production
significantly
inhibits
level
glycolysis
hinders
supply.
study
presents
cancer
treatment
combining
starvation/photothermal
therapy,
has
superior
anti‐cancer
effects
dual
reducing
levels
diminishing
cellular
capacity.
The
tumor
microenvironment
(TME)
inherently
exhibits
treatment
resistance,
which
restrains
the
therapeutic
effect.
Here,
intracellular
piezoelectric
catalysis
and
stepwise
nitric
oxide
(NO)
release
were
integrated
to
modulate
TME
for
anticancer
therapy.
A
homologous
boron
nitride
(BN)
heterostructure
(BN3:1)
was
prepared,
promotes
character
facilitates
spatial
separation
of
ultrasound
(US)-generated
charges.
electrons
dominate
reactive
oxygen
species
(ROS)
generation,
holes
also
consume
endogenous
glucose
nicotinamide
adenine
dinucleotide
phosphate
(NADPH).
simultaneous
reactions
not
only
facilitate
charge
but
disrupt
metabolism.
In
addition,
BN3:1
releases
NO
in
response
TME-specific
H+/H2O2.
Under
US
irradiation,
increased
ROS
generation
boosts
damage
DNA/mitochondria
decompose
extracellular
matrix
(ECM).
Without
US,
moderate
is
conducive
vascular
normalization,
hypoxia
relief,
PD-L1
downregulation.
Furthermore,
microbubbles
amplify
imaging
contrast,
endowing
efficient
monitoring
vitro
vivo.
It
first
time
employing
BN
nanosheets
as
sonosensitizers
donors.
synergistic
effect
grants
great
efficiency,
can
arouse
an
immune
further
fight
against
metastasis
recurrence.
ACS Applied Bio Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 29, 2025
Colloidal
nanozymes,
enzyme-mimetic
nanocatalysts
with
tunable
catalytic
activity,
are
revolutionizing
cancer
diagnosis
and
therapy
by
integrating
precision
biomedical
functionality.
Their
ability
to
regulate
redox
homeostasis,
generate
reactive
oxygen
species
(ROS),
modulate
tumor
microenvironments
provides
a
foundation
for
targeted
therapeutic
interventions,
while
their
intrinsic
properties
enhance
biosensing
imaging
early
detection.
However,
the
rational
design
of
nanozymes
remains
challenge,
particularly
in
optimizing
efficiency,
biocompatibility,
specificity
tumor-selective
reactions.
This
review
explores
how
surface
chemistry,
interfacial
engineering,
mechanisms
dictate
nanozyme
stability,
interactions
biological
systems.
We
critically
analyze
fundamental
peroxidase-like,
oxidase-like,
catalase-like,
superoxide
dismutase
(SOD)-like
reactions
driving
applications
therapy,
as
well
role
biosensors,
probes,
theranostic
platforms
diagnosis.
Additionally,
we
examine
cutting-edge
modification
strategies,
including
atomic
dispersion,
ligand
coordination,
defect
selectivity
reduce
off-target
effects.
By
catalysis
translational
applications,
this
establishes
comprehensive
framework
advancing
nanozyme-based
diagnostics
therapeutics
oncology.
