Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 20, 2024
Abstract
Radiotherapy‐induced
ferroptosis
is
accompanied
by
an
adaptive
response
to
the
expression
of
tumor
cell
suppressor
genes.
Herein,
a
degradable
and
in
situ
generated
silicomanganese
composite
system
loaded
with
carbonic
anhydrase
(CA
IX)
inhibitor
(4‐(2‐aminoethyl)
benzenesulfonamide
(ABS)
constructed
form
DSiMn‐ABS
nanosystem
improve
sensitivity
hypoxic
cells
radiotherapy
effect.
The
can
be
continuously
degraded
environment
X‐rays,
releasing
Manganese
dioxid
（MnO
2
)and
ABS;
Thereby
inhibiting
activity
CA
IX,
inducing
acidification
inside
cells,
regulating
AMP‐activating
protein
kinase
(AMPK)/Acetyl‐CoA
carboxylase(ACC)
axis
increase
ferroptosis,
depleting
glutathione
(GSH)
through
MnO
influencing
peroxidase
4
(GPX4)
activity,
which
further
inhibits
defense
ultimately
effectively
improves
therapeutic
efficiency
radiotherapy.
Ultimately,
inhibit
growth.
Therefore,
this
utilize
double‐sensitized
provide
new
ideas
for
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 10, 2025
Abstract
X‐ray
induced
photodynamic
therapy
(X‐PDT)
leverages
penetrating
to
generate
singlet
oxygen
(
1
O
2
)
for
treating
deep‐seated
tumors.
However,
conventional
X‐PDT
typically
relies
on
heavy
metal
inorganic
scintillators
and
organic
photosensitizers
produce
,
which
presents
challenges
related
toxicity
energy
conversion
efficiency.
In
this
study,
highly
biocompatible
phosphorescent
nanoscintillators
based
hydrogen‐bonded
frameworks
(HOF)
are
designed
engineered,
termed
BPT‐HOF@PEG,
enhance
in
hepatocellular
carcinoma
(HCC)
treatment.
BPT‐HOF@PEG
functions
simultaneously
as
both
scintillator
photosensitizer,
effectively
absorbing
transferring
abundant
.
Both
vitro
vivo
investigations
demonstrate
that
internalized
efficiently
produces
significant
quantities
of
upon
irradiation.
Additionally,
exposure
directly
inflicts
DNA
damage,
the
synergistic
effects
these
mechanisms
result
pronounced
cell
death
substantial
tumor
growth
inhibition,
with
a
inhibition
rate
up
90.4%
assessments.
RNA
sequencing
analyses
reveal
induces
apoptosis
Hepa1‐6
cells
while
inhibiting
proliferation,
culminating
death.
Therefore,
work
highlights
considerable
potential
efficient
HOF
nanoscintillators‐based
promising
therapeutic
approach
HCC,
providing
effective
alternative
negligible
patients
unresectable
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Oct. 8, 2024
In
diabetic
wounds,
hyperglycemia-induced
cytotoxicity
and
impaired
immune
microenvironment
plasticity
directly
hinder
the
wound
healing
process.
Regulation
of
hyperglycemic
remodeling
are
crucial.
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 31, 2025
Abstract
Targeted
delivery
of
glucose
oxidase
(GOx)
using
MXene
remains
a
great
challenge
due
to
its
poor
dispersion
and
susceptibility
oxidation,
the
hypoxia
high
glutathione
(GSH)
contents
make
situation
even
more
worrying.
Herein,
bovine
serum
albumin‐mediated
non‐chemical
modification
strategy
is
developed,
endowing
titanium
carbide
with
long‐time
water‐dispersion
further
integrating
it
as
glycolysis‐controllable
therapy
system
without
any
chemotherapeutic
agents.
The
also
constructs
an
effective
O
2
cycling
GSH
degradation
pathway,
which
fundamentally
adjusts
tumor
microenvironment
greatly
elevates
both
in
vivo
vitro
effects.
Reactive
oxygen
species
are
generated
disrupt
balance
oxidative
stress.
Moreover,
reduced
efficiency
mitochondrial
energy
production
significantly
inhibits
level
glycolysis
hinders
supply.
study
presents
cancer
treatment
combining
starvation/photothermal
therapy,
has
superior
anti‐cancer
effects
dual
reducing
levels
diminishing
cellular
capacity.
Journal of Agricultural and Food Chemistry,
Journal Year:
2024,
Volume and Issue:
72(42), P. 23008 - 23023
Published: Oct. 14, 2024
The
demand
for
food
has
increased
dramatically
as
the
global
population
increases,
putting
more
strain
on
sustainability
of
agriculture.
To
fulfill
this
requirement,
it
is
imperative
to
develop
brand-new
technologies.
application
potential
nanozymes
in
plant
and
environmental
sectors
progressively
becoming
apparent
a
result
their
effective
enzymatic
catalytic
activity
distinctive
characteristics
nanomaterials,
including
size,
specific
surface
area,
optical
properties,
thermal
properties.
Herein,
we
systematically
analyze
mechanisms
with
different
enzyme-mimetic
activities
summarize
applications
improving
crop
yields
by
regulating
ROS
levels
enhancing
stress
resistance
detecting
removing
hazardous
pollutants.
Finally,
thoroughly
challenges
faced
regarding
design,
application,
economy,
biosafety
look
forward
future
development
directions
better
serve
sustainable
