Phototherapy: progress, challenges, and opportunities

Science China Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

Language: Английский

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PdRu bimetallic nanoalloys with improved photothermal effect for amplified ROS-mediated tumor therapy

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 3, 2025

An emerging strategy in cancer therapy involves inducing reactive oxygen species (ROS), specifically within tumors using nanozymes. However, existing nanozymes suffer from limitations such as low reactivity, poor biocompatibility, and limited targeting capabilities, hindering their therapeutic efficacy. In response, the PdRu@PEI bimetallic nanoalloys were constructed with well-catalytic activities effective separation of charges, which can catalyze hydrogen peroxide (H2O2) to toxic hydroxyl radical (·OH) under near-infrared laser stimulation. Through facilitating electron transfer enhancing active sites, enhanced peroxidase-like (POD-like) enzymatic activity glutathione (GSH) depletion abilities are boosted through a simple co-reduction process, leading promising anti-tumor activity. The between Pd Ru contributes POD-like Then, by oxidizing endogenous overexpressed GSH, cycling prevents GSH consuming ROS. Furthermore, surface plasmon resonance effect on ensures its photothermal performance local heating, further promoting integrated multi-modal approach has demonstrated significant anti-cancer effects vivo studies. exhibit high catalytic efficiency excellent offering valuable insights for development nano-catalysts/enzymes biomedical applications.

Language: Английский

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Developing an advanced diagnostic model for hepatocellular carcinoma through multi-omics integration leveraging diverse cell-death patterns

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: July 9, 2024

Hepatocellular carcinoma (HCC), representing more than 80% of primary liver cancer cases, lacks satisfactory etiology and diagnostic methods. This study aimed to elucidate the role programmed cell death-associated genes (CDRGs) in HCC by constructing a model using single-cell RNA sequencing (scRNA-seq) (RNA-seq) data. Six categories CDRGs, including apoptosis, necroptosis, autophagy, pyroptosis, ferroptosis, cuproptosis, were collected. RNA-seq data from blood-derived exosomes sourced exoRBase database, tissues TCGA scRNA-seq GEO database. Subsequently, we intersected differentially expressed (DEGs) cohort databases with as well DEGs obtained datasets. Candidate biomarker then screened clinical indicators machine learning approach, resulting construction seven-gene for HCC. Additionally, spatial transcriptome (stRNA-seq) Mendeley portal used investigate underlying mechanisms these seven key their association immune checkpoint blockade (ICB) therapy. Finally, validated expression molecules through quantitative Polymerase Chain Reaction (qPCR) immunohistochemistry experiments. Collectively, total 50 samples 104,288 single cells. Following meticulous screening, established HCC, demonstrating high efficacy both (training set: AUC = 1; testing 0.847) 0.976). Subsequent analysis revealed that cluster 3 exhibited higher stemness index could serve starting point differentiation trajectory cells, also displaying abundant interactions other types microenvironment. Notably, TRIB3 NQO1 displayed elevated levels Experimental validation further confirmed tumor patients. stRNA not only substantiated findings but suggested patients might respond favorably ICB The demonstrated remarkable accuracy emerging promising tool therapeutic target

Language: Английский

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DDR-1 Targeted Fluorescent Contrast Agents for Enhanced Near-infrared Tumor Imaging

Sensors and Actuators B Chemical, Journal Year: 2025, Volume and Issue: unknown, P. 137475 - 137475

Published: Feb. 1, 2025

Language: Английский

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Lab‐in‐Cell: A Covalent Photosensitizer Reverses Hypoxia and Evokes Ferroptosis and Pyroptosis for Enhanced Anti‐Tumor Immunity

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 23, 2025

Abstract Photodynamic immunotherapy presents a non‐invasive strategy characterized by spatiotemporal control and minimal side effects to induce immunogenic cell death (ICD). This approach significantly enhances the release of tumor‐associated antigens damage‐associated molecular patterns, thereby improving cancer outcomes. However, hypoxia antioxidant defenses at tumor sites considerably diminish efficacy photodynamic immunotherapy. In this work, covalent warhead, alkyneamide, is introduced into an AIE photosensitizer develop novel photosensitizer, MBTP‐PA, which targets redox systems facilitates ferroptosis‐ pyroptosis‐mediated thiol‐yne click reactions. The interacts with intracellular thiol compounds such as cysteine glutathione, disrupting system alleviating hypoxia. results in enhanced therapy (PDT) compared non‐covalent MBTP‐A. Furthermore, conjunction PDT, reaction can activate ICD through ferroptosis pyroptosis, enhancing anti‐tumor immunity. Notably, vivo injection MBTP‐PA nanoparticles site led elimination primary tumors, inhibiting distal tumors exhibiting effects. Therefore, work not only integrates reactions cellular systems, but also paves way for developing photosensitizers.

Language: Английский

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Albumin Modulated Homodimer as an Efficient Photosensitizer for Long‐Term Imaging‐Guided Tumor Therapy Directed with Sunlight Irradiation

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Abstract The reactive oxygen species (ROS) amplification caused by inevitable plasma albumin encapsulation is still a challenge to circumvent the systemic adverse effects in photodynamic therapy (PDT) process. Herein, disulfide bond linked homodimer, Cy1280, which modulated accurately balance fluorescence and ROS generation exhibit weak sealed PDT effect during blood circulation, exploited. Cy1280 can be specifically internalized dispersed at tumor site via Organic Anion Transporter Proteins (OATPs) thiol‐disulfide exchange mediated synergistic uptake activated after mild sunlight irradiation (100 ± 5 Klx) sensitize neighboring cellular mitochondria execute direct protein dysfunction effect. dynamic covalent chemistry (DCC) facilitates prolonged sustained retention tumors (>336 h) demonstrates efficacy of imaging‐guided solid‐tumor tumor‐bearing BALB/C mice. This study resolves stubborn impotent penetration bulky‐sized nanoparticles high interstitial pressure with manner, long‐term circulation manipulated also improve whole body phototoxic symptom. advantageous feature provides promising candidate for overcoming off‐target phototoxicity inadequate accumulation challenges clinical translation photosensitizers (PSs).

Language: Английский

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Electrostatically Stabilized Light-Activated Membrane Delivery System: Overcoming Membrane Flexibility and Self-Repair to Enhance Tumor Therapy

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Cell membrane-coated nanoparticle-based delivery systems often struggle with inevitable drug leakage during the process and inefficient release at tumor site, resulting in unsatisfactory antitumor outcomes. Here, we present an electrostatically stabilized light-activated membrane system (Hybrid nanoparticles, [Hm]@NPs) for leak-free delivery, coupled precisely site-specific controllable release, to elevate cancer treatment. [Hm]@NPs are constructed by encapsulating aggregation-induced emission (AIE) photosensitizer (Phenalen-1-one-quinoline malonitrile-thiophene tribenamine, Phe-Qui-T) into a positively charged reactive oxygen species (ROS)-responsive polymer (F127-TP-U11) form nanoparticle then coating it negatively hybrid containing red blood cell Panc-1 membrane. high stability effectively prevent through electrostatic interaction between nanoparticle. Simultaneously, Phe-Qui-T light-controlled ROS generation efficiently destroys both ROS-responsive membrane, ensuring precise sufficient while enabling photodynamic therapy (PDT), thereby augmenting efficacy. show impressive inhibition pancreatic mouse models, highlighting potential of this membrane-disruption strategy advanced nanodelivery design.

Language: Английский

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Strategies to enhance the penetration of nanomedicine in solid tumors

Biomaterials, Journal Year: 2025, Volume and Issue: 321, P. 123315 - 123315

Published: April 4, 2025

Language: Английский

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Synergistic Comprehensive Activation Methods for Dual‐Modality PDT and Hypoxia‐Triggered Chemotherapy Guided by NIR‐II Imaging beyond 1700 nm in Deep Tumors

Small, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Abstract Although photodynamic therapy (PDT) holds great promise for applications in cancer treatment, it has limited effectiveness against deep hypoxic tumors. Moreover, the lack of visualization guidance precision theranostics poses additional challenges, hindering its broader clinical adoption. By combining NIR‐IIc (1800 nm) imaging with internally and externally activatable dual‐modality PDT hypoxia‐triggered chemotherapy, this study proposes a conceptual framework to overcome these limitations. This approach involves use photoswitchable lanthanide‐doped nanoparticles featuring Tm 3+ ‐activated upconversion/downshifting emissions coupled carboxyl‐terminated Ir(III) complex‐based Type I/II photosensitizer form nanophotosensitizer. The findings demonstrate that system enabled upon 808/980 nm excitation while selectively activating external under 980 irradiation, thereby ensuring accurate minimizing phototoxicity risk. complex conjugates luminol self‐illuminating photosensitizer, which can respond elevated H 2 O levels tumor microenvironment, effectively catalyzing chemiluminescence‐assisted PDT. aggravates hypoxia, turn activates hypoxia‐activatable prodrugs like tirapazamine, resulting synergistic antitumor effect. With imaging‐guided PDT, introduces groundbreaking unites significantly advancing precise effective treatment

Language: Английский

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Self-assembled nanoprobes for cancer phototheranostics

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 538, P. 216643 - 216643

Published: April 18, 2025

Language: Английский

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