Type‐Transformational BioHJzyme Enabled by Composition Modulation‐Mediated Energy Band Engineering for Diabetic Infectious Wound Healing

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Abstract The dilemma of diabetic infectious wound healing lies in inhibiting the pathogenic colonization and regulating hyperglycemia. pivotal anti‐pathogenic efficiency is focused on confined gradually weaken reactive oxygen species (ROS) yield peculiar micromilieu owing to materials transformation/dissolution. There, type‐transformational bio‐heterojunction enzyme (BioHJzyme) with operando composition‐modulation proposed, which consisted by glucose oxidase (GOx) decorated type‐I FeSe 2 /Cu O heterojunction. It exhibits robust catalytic produce ROS. Followed, heterojunction can be transformed into dual Z‐scheme a composition /CuSe/Cu primed acid meliorative energy band. conducive NIR‐induced capabilities improve ROS yield. GOx consume H as an amplifier. combined followed enhanced powerfully remove colonization. On top that, sample downgrade Forkhead box (FoxO) signaling pathway regulate cell cycle, facilitate proliferation, further promote repairment. This work provides effective feasible antibacterial strategy way thinking for healing.

Language: Английский

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pH-responsive and self-adaptive injectable sodium alginate/carboxymethyl chitosan hydrogel accelerates infected wound healing by bacteriostasis and immunomodulation

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: unknown, P. 123322 - 123322

Published: Jan. 1, 2025

Language: Английский

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Advancements in nanozymes research for the management of chronic wounds

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 500, P. 157299 - 157299

Published: Nov. 1, 2024

Language: Английский

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Mechanisms of hydrogen sulfide-mediated neuroprotection: current understanding and future directions

Neuroscience and Behavioral Physiology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 9, 2024

Language: Английский

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Photo-Controlled extracellular electron transfer in Non-Extracellular respiratory bacteria by constructing a nanoscale interface material for energy transformation

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159553 - 159553

Published: Jan. 1, 2025

Language: Английский

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Sono-piezodynamic therapy for drug-resistant bacteria infection

Cell Reports Physical Science, Journal Year: 2025, Volume and Issue: 6(3), P. 102451 - 102451

Published: Feb. 20, 2025

Language: Английский

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Vacancies-Rich Z-Scheme VdW Heterojunction as H2S-Sensitized Synergistic Therapeutic Nanoplatform against Refractory Biofilm Infections

Biomaterials, Journal Year: 2025, Volume and Issue: 320, P. 123258 - 123258

Published: March 13, 2025

Language: Английский

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Jahn–Teller-Driven Electronic Modulation of Bio-Heterojunction for Wound Regeneration after Postoperative Tumor Resection

Nano Letters, Journal Year: 2025, Volume and Issue: unknown

Published: April 12, 2025

Abundant ·OH, 1O2, and ·O2- provide an efficient methodology for rapid tumor bacteria killing, whereas a limitation focuses on the catalytic efficiency. Thus, Jahn-Teller-driven electronic modulation of bioheterojunction (bioHJ) platform is developed remedy in diabetic infectious wound regeneration after postoperative resection. The bioHJ composed MoTe2/MnO2 glucose oxidase (GOx). GOx depletes to H2O2, which intercepts their metabolism. H2O2 can be further converted into highly lethal ·OH owing peroxidase-mimetic activity via Jahn-Teller effect, while GSH consumed due its GPx-mimetic activity. Both amplified upon NIR irradiation as NIR-activatable enzyme-mimetic activities. In vivo studies subcutaneous model authenticate ability kill tumor, defeat bacterial infection, accelerate regeneration. This work enlightens powerful resection using engineered bioHJ.

Language: Английский

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Review of light activated antibacterial nanomaterials in the second biological window

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 15, 2025

Language: Английский

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An Intelligent and Conductive Hydrogel with Multiresponsive and ROS Scavenging Properties for Infection Prevention and Anti‐Inflammatory Treatment Assisted by Electrical Stimulation for Diabetic Wound

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: May 8, 2025

Abstract Diabetic wounds experience a hyperglycemic, hypoxic environment, combined with ongoing oxidative stress and inflammatory imbalances, significantly disrupts normal healing process. Advanced hydrogels have been considered one of the most exciting medical biomaterials for potential in healing. Herein, novel conductive hydrogel (HEPP), designed to release nanozyme (PTPPG) response its microenvironment, was created facilitate glucose (Glu) catabolism. Furthermore, HEPP integrates photodynamic therapy (PDT), photothermal (PTT), self‐cascading reactive oxygen species (ROS) prevent bacterial infections while ensuring continuous supply (O 2 ) wound. The not only adeptly controls high ROS levels, but also enhances regulation inflammation wound area via electrical stimulation (ES), thereby promoting that is supported by immune response. Studies conducted vitro, along transcriptomic analyses, indicate ES primarily mitigates regulating Interleukin‐6 (IL‐6) tumor necrosis factor‐α (TNF‐α). effects are connected their impact on TNF signaling pathways. By reducing formation employing effectively lessen inflammation, this approach offers an innovative method manage complicated diabetic wounds, ulcers, range conditions linked infections.

Language: Английский

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