ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(51), P. 70256 - 70273
Published: Dec. 13, 2024
Despite
the
great
progress
of
various
multifunctional
wound
dressings,
it
is
challenging
to
simultaneously
achieve
complete
healing
and
functional
remodeling
for
diabetic
foot
ulcers
refractory
chronic
wounds.
Aiming
comprehensively
regulate
inflammation,
angiogenesis,
metabolism
processes,
herein,
a
novel
kind
dynamic
hyaluronic
acid
(HA)
hydrogel
was
designed
by
combining
boronate
coordination
chemistry.
Besides
having
injectability,
self-healing,
detachment
properties,
HA
hydrogels
presented
wound-responsive
degradation
controllable
H2S
release.
They
could
efficiently
polarize
M1-to-M2
polarization
inflammatory
cytokine
secretion
multiple
inflammation-related
mRNA
expressions
through
cooperative
actions
reactive
oxygen
species
elimination
+
release
Zn2+
regulation,
thus
driving
inflammation
into
proliferation
stages.
Moreover,
screened
lead
HTZS
angiogenesis-related
signaling
pathways
processes
promote
neovascularization
mature
vessel
formation,
re-epithelization,
high-level
collagen-I
deposition,
dense
hair
follicle
regeneration,
achieving
in
Importantly,
this
work
opens
new
avenue
design
biopolymer
high-performance
dressing
decipher
key
role
orchestrated
regulations
inflammation–angiogenesis–metabolism
on
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 2, 2025
Abstract
The
dilemma
of
diabetic
infectious
wound
healing
lies
in
inhibiting
the
pathogenic
colonization
and
regulating
hyperglycemia.
pivotal
anti‐pathogenic
efficiency
is
focused
on
confined
gradually
weaken
reactive
oxygen
species
(ROS)
yield
peculiar
micromilieu
owing
to
materials
transformation/dissolution.
There,
type‐transformational
bio‐heterojunction
enzyme
(BioHJzyme)
with
operando
composition‐modulation
proposed,
which
consisted
by
glucose
oxidase
(GOx)
decorated
type‐I
FeSe
2
/Cu
O
heterojunction.
It
exhibits
robust
catalytic
produce
ROS.
Followed,
heterojunction
can
be
transformed
into
dual
Z‐scheme
a
composition
/CuSe/Cu
primed
acid
meliorative
energy
band.
conducive
NIR‐induced
capabilities
improve
ROS
yield.
GOx
consume
H
as
an
amplifier.
combined
followed
enhanced
powerfully
remove
colonization.
On
top
that,
sample
downgrade
Forkhead
box
(FoxO)
signaling
pathway
regulate
cell
cycle,
facilitate
proliferation,
further
promote
repairment.
This
work
provides
effective
feasible
antibacterial
strategy
way
thinking
for
healing.
Nano Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 12, 2025
Abundant
·OH,
1O2,
and
·O2-
provide
an
efficient
methodology
for
rapid
tumor
bacteria
killing,
whereas
a
limitation
focuses
on
the
catalytic
efficiency.
Thus,
Jahn-Teller-driven
electronic
modulation
of
bioheterojunction
(bioHJ)
platform
is
developed
remedy
in
diabetic
infectious
wound
regeneration
after
postoperative
resection.
The
bioHJ
composed
MoTe2/MnO2
glucose
oxidase
(GOx).
GOx
depletes
to
H2O2,
which
intercepts
their
metabolism.
H2O2
can
be
further
converted
into
highly
lethal
·OH
owing
peroxidase-mimetic
activity
via
Jahn-Teller
effect,
while
GSH
consumed
due
its
GPx-mimetic
activity.
Both
amplified
upon
NIR
irradiation
as
NIR-activatable
enzyme-mimetic
activities.
In
vivo
studies
subcutaneous
model
authenticate
ability
kill
tumor,
defeat
bacterial
infection,
accelerate
regeneration.
This
work
enlightens
powerful
resection
using
engineered
bioHJ.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 8, 2025
Abstract
Diabetic
wounds
experience
a
hyperglycemic,
hypoxic
environment,
combined
with
ongoing
oxidative
stress
and
inflammatory
imbalances,
significantly
disrupts
normal
healing
process.
Advanced
hydrogels
have
been
considered
one
of
the
most
exciting
medical
biomaterials
for
potential
in
healing.
Herein,
novel
conductive
hydrogel
(HEPP),
designed
to
release
nanozyme
(PTPPG)
response
its
microenvironment,
was
created
facilitate
glucose
(Glu)
catabolism.
Furthermore,
HEPP
integrates
photodynamic
therapy
(PDT),
photothermal
(PTT),
self‐cascading
reactive
oxygen
species
(ROS)
prevent
bacterial
infections
while
ensuring
continuous
supply
(O
2
)
wound.
The
not
only
adeptly
controls
high
ROS
levels,
but
also
enhances
regulation
inflammation
wound
area
via
electrical
stimulation
(ES),
thereby
promoting
that
is
supported
by
immune
response.
Studies
conducted
vitro,
along
transcriptomic
analyses,
indicate
ES
primarily
mitigates
regulating
Interleukin‐6
(IL‐6)
tumor
necrosis
factor‐α
(TNF‐α).
effects
are
connected
their
impact
on
TNF
signaling
pathways.
By
reducing
formation
employing
effectively
lessen
inflammation,
this
approach
offers
an
innovative
method
manage
complicated
diabetic
wounds,
ulcers,
range
conditions
linked
infections.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(48)
Published: Sept. 30, 2024
Abstract
Deferred
diabetic
skin
healing
is
an
ever‐growing
complication
owing
to
the
hyperglycemic
microenvironment,
which
accelerates
generation
of
advanced
glycated
end
products
(AGEs)
and
provides
a
hotbed
for
pathogenic
infection.
Here,
H
2
S‐evolving
bio‐heterojunction
enzyme
(BioHJzyme),
consisted
by
MXene/FeS
glucose
oxidase
(GOx)
devised.
It
presents
glutathione
peroxidase
(GPx)‐
(POD)‐mimetic
antibacterial
activity
anti‐pathogens
wound
regeneration
AGEs
depression.
The
GOx
catalyzes
glucose,
resulting
in
reducing
bacterial
nutrient
supplying
O
.
POD‐mimetic
BioHJzyme
hydroxyl
radical
(•OH)
with
turnover
number
4.45
×
10
−1
s
,
while
GPx‐mimetic
it
consumes
further
•OH
accumulation.
can
be
enhanced
near
infrared
laser
(NIR)
irradiation
efficient
separation
electron‐hole
pairs
originated
from
heterostructure,
NIR‐activatable
1
production.
Moreover,
evolves
S
acidic
environment,
acting
as
donor,
protects
cells
around
oxidative
damage
AGEs,
rescues
mitochondrial
respiration,
improves
extracellular
matrix
deposition
ameliorates
dysfunction
fibroblasts
through
TGF‐β/Smad
pathway.
work
proof‐of‐concept
bacteria‐invaded
via
BioHJzyme.
