Journal of environmental chemical engineering, Journal Year: 2024, Volume and Issue: unknown, P. 114877 - 114877
Published: Nov. 1, 2024
Language: Английский
Aggregate, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 15, 2025
ABSTRACT Colorectal cancer (CRC) screening and early diagnosis is an effective strategy for reducing CRC mortality. However, the current detection methods involve exorbitant costs complex procedures, which are inconvenient large‐scale screening. Given its high prevalence in malignant tissues feces of patients, Fusobacterium nucleatum ( F. ) has emerged as a crucial biomarker CRC. Herein, we propose ‐specific recognition diagnosis. A novel nanobioprobe (AIE‐Pep) with aggregation‐induced emission (AIE) characteristics was synthesized by conjugating red/near‐infrared (NIR) emissive AIE luminogen (AIEgen) FadA‐targeting peptide (ASANWTIQYND). The robust binding affinity between FadA on allows AIE‐Pep NPs to adhere selectively , emits strong red/NIR fluorescence. In model orthotopic CRC, can precisely localize around Moreover, demonstrated limit (LOD) 82.97 CFU/mL could significantly differentiate mice from those normal mice. Overall, this study presents pivotal approach specifically identifying holds immense potential
Language: Английский
Citations
1
Macromolecular Rapid Communications, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 21, 2025
Aggregation-induced emission (AIE) materials have gained significant attention for their unique fluorescence enhancement in the aggregated state. However, combining rigid polymers with AIE molecules to enhance luminescent properties remains be investigated. In this work, two novel AIE-active polyarylethersulfone (PAES) derivatives are synthesized by incorporating tetraphenylethene (TPE) into either side chain or main of PAES, resulting side-chain polyarylethersulfone-tetraphenylethene (PAES-TPE) and main-chain (m-PAES-TPE), respectively. These designed investigate influence polymer backbone on TPE. The incorporation TPE PAES resulted a notable redshift compared pure Notably, m-PAES-TPE50%, 50% molar content TPE, exhibited quantum yield 57.43%, more than twice that powder. Thermal analysis showed both PAES-TPE m-PAES-TPE excellent thermal stability temperature-dependent fluorescence. Additionally, these processed hydrophobic nanoparticles, vitro experiments demonstrated good biocompatibility cancer cell bioimaging. This work highlights potential advanced bioimaging applications.
Language: Английский
Citations
0
Chemical & Biomedical Imaging, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 14, 2025
Language: Английский
Citations
0
Chemical Science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
This review provides an overview of activatable peptide–AIEgen conjugates for tumor imaging, with emphasis on the most recent breakthroughs in past three years (from 2022 to late 2024)
Language: Английский
Citations
0
Aggregate, Journal Year: 2025, Volume and Issue: unknown
Published: March 4, 2025
ABSTRACT Aggregation‐induced emission (AIE) and thermally activated delayed fluorescence (TADF) are two optoelectronic properties with great potential for applications. However, metal nanoclusters exhibiting both AIE TADF characteristics have not been extensively studied. This study investigates a binary cocrystal system based on silver nanoclusters—Ag 6 (Et 2 NCS ) ·[Ag 11 (AdmS) 3 ] ( 1‐Ag ·(Ag ), aiming to explore the synergistic effects between flexible‐alkyl dithiol rigid monothiol ligands. Due introduction of Ag structures, exhibits enhanced stability modulated optical properties. The tricluster demonstrates significant behavior, an approximately 15‐fold increase in intensity when water volume fraction f w is 60%. Single‐crystal X‐ray diffraction analysis indicates that effect originates from intercluster hydrogen bonding interactions, which drive self‐assembly sub‐clusters form hierarchical thereby suppressing ligand rotation. In addition, phenomenon temperature range 100−175 K. order further investigate variations properties, unitary clusters, 2‐Ag ‐AS t BuS) 3‐Ag ‐BS synthesized, their roles regulating explored through exchange reactions. provides important insights development efficient luminescent materials highlighting critical structural configuration.
Language: Английский
Citations
0
Small, Journal Year: 2025, Volume and Issue: unknown
Published: March 17, 2025
Abstract The reactive oxygen species (ROS) amplification caused by inevitable plasma albumin encapsulation is still a challenge to circumvent the systemic adverse effects in photodynamic therapy (PDT) process. Herein, disulfide bond linked homodimer, Cy1280, which modulated accurately balance fluorescence and ROS generation exhibit weak sealed PDT effect during blood circulation, exploited. Cy1280 can be specifically internalized dispersed at tumor site via Organic Anion Transporter Proteins (OATPs) thiol‐disulfide exchange mediated synergistic uptake activated after mild sunlight irradiation (100 ± 5 Klx) sensitize neighboring cellular mitochondria execute direct protein dysfunction effect. dynamic covalent chemistry (DCC) facilitates prolonged sustained retention tumors (>336 h) demonstrates efficacy of imaging‐guided solid‐tumor tumor‐bearing BALB/C mice. This study resolves stubborn impotent penetration bulky‐sized nanoparticles high interstitial pressure with manner, long‐term circulation manipulated also improve whole body phototoxic symptom. advantageous feature provides promising candidate for overcoming off‐target phototoxicity inadequate accumulation challenges clinical translation photosensitizers (PSs).
Language: Английский
Citations
0
Bioconjugate Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: March 27, 2025
Photodynamic antimicrobial therapy (PDAT) for efficient bacterial infection eradication critically relies on photosensitizers (PSs) that can specifically target and disrupt membranes. However, the complex membrane architecture of Gram-negative bacteria poses a significant challenge to efficacy most aggregation-induced emission (AIE) PSs. Herein, we introduce TPQ, an AIE PS meticulously designed overcome this by incorporating outer disruption ability, thereby boosting PDAT against bacteria. TPQ demonstrated excellent microbial imaging potent activity both Gram-positive bacteria, attributed its inherent fluorescence, high singlet oxygen generation, balanced electrostatic hydrophobic interactions with Notably, achieved exceptional (>97% efficacy) while exhibiting minimal cytotoxicity mammalian cells. Furthermore, TPQ-mediated effectively healed Escherichia coli-infected wounds mice models assured biosafety. This work provides valuable insights into rational design PSs highlights synergistic effect advancing applications, particularly recalcitrant infections.
Language: Английский
Citations
0
European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 117672 - 117672
Published: April 1, 2025
Language: Английский
Citations
0
Chemical Science, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
AIE luminogens (AIEgens) are a class of unique fluorescent molecules that exhibit significantly enhanced luminescence properties and excellent photostability in the aggregated state. Recently, it has been found some AIEgens can produce reactive oxygen species, which means they may have potential enzyme-like activities thus termed "AIEzymes". Consequently, discovery design novel with emerged as new exciting research direction. Additionally, enhance catalytic efficiency traditional nanozymes by direct combination, thereby endowing multifunctionality. In this regard, aggregation-induced emission (AIE) properties, represents win-win integration, not only take full advantage low cost stability nanozymes, but also incorporate biocompatibility fluorescence AIEgens. These synergistic compounds bring about opportunities for various applications, making AIEzymes interest biomedical research, food analysis, environmental monitoring, especially imaging-guided diagnostics. This review will provide an overview latest strategies achievements rational preparation AIEzymes, well current trends, future challenges prospective solutions. We expect work encourage motivate more people to study explore further promote their applications fields.
Language: Английский
Citations
1
Journal of environmental chemical engineering, Journal Year: 2024, Volume and Issue: unknown, P. 114877 - 114877
Published: Nov. 1, 2024
Language: Английский
Citations
0