Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 248, P. 114468 - 114468
Published: Dec. 20, 2024
Language: Английский
Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: unknown, P. 104653 - 104653
Published: Feb. 1, 2025
Language: Английский
Citations
4
Advanced Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 12, 2025
Ulcerative colitis (UC) is a chronic gastrointestinal inflammatory disorder with rising prevalence. Due to the recurrent and difficult-to-treat nature of UC symptoms, current pharmacological treatments fail meet patients' expectations. This study presents machine learning-assisted high-throughput screening strategy expedite discovery efficient nanozymes for treatment. Therapeutic requirements, including antioxidant property, acid stability, zeta potential, are quantified predicted by using learning model. Non-quantifiable attributes, intestinal barrier repair efficacy biosafety, assessed via screening. Feature significance analysis, sure independence screening, sparsifying operator symbolic regression reveal high-dimensional structure-activity relationships between material features therapeutic needs. SrDy
Language: Английский
Citations
2
Cancer Nanotechnology, Journal Year: 2025, Volume and Issue: 16(1)
Published: Jan. 17, 2025
Emphasizing the significance of cancer-associated fibroblasts (CAFs), non-malignant yet pivotal players within tumor microenvironment (TME), this review illuminates role inflammatory subtype (iCAF) as catalysts in cancer proliferation, metastasis, and therapeutic resistance. Given their paramount importance, targeting CAFs emerges a robust strategy evolving landscape immunotherapy. Nanomaterials, distinguished by unique features malleability, hold considerable promise biomedicine, especially precision-oriented domain therapy. Their aptitude for modulating immune responses, amplifying drug efficacy through precise delivery, discerningly focusing on cells TME situates nanomaterials formidable tools to transcend boundaries set conventional treatments. This scrutinizes convoluted interplay among CAFs, cells, TME. It further showcases widely utilized management. We underscore potential nanoscale delivery systems directed at underscoring transformative power revolutionizing therapies, enhancing precision, culminating improved patient outcomes.
Language: Английский
Citations
2
Journal of Biomaterials Science Polymer Edition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 27
Published: Jan. 9, 2025
Molecular Dynamics (MD) simulations are now widely utilized in pharmaceutical nanotechnology to gain deeper understanding of nanoscale processes imperative drug design. This review has also detailed how MD simulation can be employed the study drug-nanocarrier interactions, controlling release chemical compounds from delivery systems and increasing solubility bioavailability nanocarriers. Furthermore, contributes examining systems, measuring toxic effects, determining biocompatibility nanomedical systems. With incorporation artificial intelligence use hybrid gone a step ahead model other niches biology that make tremendous opening develop highly selective nanomedications. Nevertheless, with well-known issues such as computational constraints discrepancy between silico experiment results, remains work progress, considerable promise for replacing or supplementing existing approaches development precision medicine nanomedicine, continued progression healthcare hopeful.
Language: Английский
Citations
1
Materials Today Chemistry, Journal Year: 2025, Volume and Issue: 45, P. 102640 - 102640
Published: March 18, 2025
Language: Английский
Citations
0
Medical Oncology, Journal Year: 2025, Volume and Issue: 42(5)
Published: March 25, 2025
Language: Английский
Citations
0
Nano TransMed, Journal Year: 2025, Volume and Issue: unknown, P. 100083 - 100083
Published: April 1, 2025
Language: Английский
Citations
0
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 514, P. 163228 - 163228
Published: April 30, 2025
Language: Английский
Citations
0
ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown
Published: May 12, 2025
RNA interference (RNAi) has emerged as a transformative approach for cancer therapy, enabling precise gene silencing through small interfering (siRNA). However, the clinical application of siRNA-based treatments faces challenges such rapid degradation, inefficient cellular uptake, and immune system clearance. Nanotechnology-enhanced siRNA delivery revolutionized therapy by addressing these limitations, improving stability, tumor-specific targeting, therapeutic efficacy. Recent advancements in nanocarrier engineering have introduced innovative strategies to enhance safety precision therapies, offering new opportunities personalized medicine. This review highlights three key innovations nanotechnology-enhanced delivery: artificial intelligence (AI)-driven design, multifunctional nanoparticles combined strategies, biomimetic nanocarriers enhanced biocompatibility. AI-driven utilize machine learning algorithms optimize nanoparticle properties, drug release profiles minimizing off-target effects. Multifunctional integrate with chemotherapy, immunotherapy, or photothermal synergistic treatment approaches that outcomes reduce resistance. Biomimetic nanocarriers, including exosome-mimicking systems cell-membrane-coated nanoparticles, improve circulation time, evasion, targeted tumor delivery. These collectively precision, efficiency, therapies. The scope novelty lie their ability overcome primary barriers while paving way clinically viable solutions. provides comprehensive analysis latest developments fabrication, preclinical studies, assessments. By integrating multifunctionality, biomimicry, holds immense potential future therapy.
Language: Английский
Citations
0
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16
Published: May 14, 2025
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, amyloid-beta (Aβ) aggregation, tau pathology, and chronic neuroinflammation. Among these, neuroinflammation plays crucial role in exacerbating progression, making it an attractive therapeutic target. However, the presence of blood-brain barrier (BBB) significantly limits effective delivery agents to brain, necessitating novel drug strategies. Nanocarrier-based systems have emerged as promising solution these challenges, offering targeted transport, enhanced BBB penetration, improved bioavailability while minimizing systemic toxicity. This review explores current advancements nanocarrier-mediated for AD, focusing on mechanisms neuroinflammation, nanocarriers overcoming BBB, their ability modulate inflammatory pathways. Furthermore, discusses preclinical validation strategies key including safety concerns, large-scale production limitations, regulatory hurdles that must be addressed enable clinical translation. Future perspectives emphasize integration nanotechnology with precision medicine, gene therapy, artificial intelligence optimize nanocarrier design individualized AD treatment. By obstacles, hold potential revolutionize approaches other diseases.
Language: Английский
Citations
0