Development of a pH‐Responsive Antimicrobial and Potent Antioxidant Hydrogel for Accelerated Wound Healing: A Game Changer in Drug Delivery DOI Open Access
Qixiang Gui, Neng Ding,

Haimei Wu

et al.

Advanced Biology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 14, 2024

Abstract Stimuli‐responsive hydrogels have the capability to alter their state in response changes physiological signals within application environment, providing distinct benefits drug delivery applications. Here, acidic pH typically found acutely infected wounds can be effectively managed by incorporating a pH‐responsive Ag + loaded system hydrogel, thereby ensuring efficient use and preventing potential toxicity from sudden release of silver ions. The antimicrobial composite hydrogel HAMA/GelMA‐CA/Ag provides some tissue adhesion accelerates wound healing. GelMA‐CA is synthesized modifying gelatin methacryloyl (GelMA) with caffeic acid (CA), while hyaluronic (HAMA) introduced prepare double network hydrogel. Silver nitrate then make it through formation coordination between polyphenolic structure exhibited excellent antioxidant properties strong activity against both Staphylococcus aureus (S. aureus) Escherichia coli (E. coli). Furthermore, accelerated promotion healing rat model S. aureus‐infected wounds. In conclusion, promising bioactive material that used as dressing promote

Language: Английский

Five-Cavity Resonance Inspired, rGO Nano-Sheet Reinforced, Multi-Site Voice Synergetic Detection Hydrogel Sensors with Diverse Self-Adhesion and Robust Wireless Transmissibility DOI Creative Commons
Yue Wu, Kewei Zhao,

J.C. Wang

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(4), P. 233 - 233

Published: March 23, 2025

The practical application of flexible sensors in sound detection is significantly hindered by challenges such as information isolation, fragmentation, and low fidelity. To address these challenges, this work developed a composite hydrogel via one-pot method, employing polyvinyl alcohol (PVA) the first network, polyacrylic acid (PAA) second two-dimensional nanomaterials—reduced graphene oxide (rGO)—generated through redox reaction polydopamine (PDA) (GO) conductive fillers. uniformly distributed rGO within forms an efficient endowing material with high sensitivity (GF = 0.64), excellent conductivity (8.15 S m−1), rapid response time (350 ms), outstanding stability. synergistic interaction between PDA PAA modulates hydrogel’s adhesion (0.89 kPa), enabling conformal attachment to skin surfaces. designed rGO@PVA-PAA hydrogel-based sensor effectively monitors vibrations across diverse frequencies originating from five vocal cavities (head, nasal, oral, laryngeal, thoracic cavities) during singing. Integrated multi-position synchronization Bluetooth wireless sensing technologies, system achieves coordinated monitoring multiple cavities. Furthermore, demonstrates versatility detecting physiological signals, including electrocardiograms, subtle vibrations, multi-scale body movements, highlighting its broad applicability biomedical motion-sensing applications.

Language: Английский

Citations

0

Non-starch polysaccharides from nutmeg: Preparation process and bioactivity DOI
Zhenlei Wang, Wen‐Chih Cheng, Zitong Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 310, P. 143341 - 143341

Published: April 18, 2025

Language: Английский

Citations

0

Gellan gum-sialoglycan conjugates: a mucin mimic for alleviating inflammation in Caco-2 cells and modulating gut microbiota in the elderly DOI
Tiantian Zhang, Yuying Wang, Yiqun Gu

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 310, P. 143478 - 143478

Published: April 24, 2025

Language: Английский

Citations

0

3D Printing of High Strength Thermally Stable Sustainable Lightweight Corrosion-Resistant Nanocomposite by Solvent Exchange Postprocessing DOI
Sayan Ganguly, Xiaowu Tang

ACS Sustainable Chemistry & Engineering, Journal Year: 2024, Volume and Issue: 13(1), P. 423 - 435

Published: Dec. 18, 2024

3D printing of cellulose acetate (CA)-based, sustainable, thermally stable nanocomposites is challenging due to their fast drying, nozzle clogging, and complex rheological behavior. In this study, we developed an extrusion-printable ink based on CA nanocrystals (CNCs) using a trisolvent wet blending method, followed by postprinting pore-inducing processing technique. The performed well in both tensile- compression-based mechanical tests. Moreover, the demonstrated malleable deformation during compression testing without any premature fracture, unlike commercial commodity plastics. thermal stability was assessed thermogravimetric analysis, showing ∼ 28 °C improvement onset degradation temperature after addition 5 wt % CNCs. Solvent tolerance tests against various solvents indicated excellent solvent resistance. lightweight showed no deterioration, even long-term exposure water vapor. Finally, anticorrosion behavior samples evaluated as coating material for metal (Al), demonstrating protection corrosive acid vapors. Thus, application 3D-printed exhibits significant promise implementation fields lightweight, anticorrosive engineering materials.

Language: Английский

Citations

2

Injectable and Self-Healing MXene-Reinforced pH-Responsive Hydrogel: Realizing Low-Friction and Durable Lubrication DOI

Yan Huang,

Zhangpeng Li, Yaochen Wang

et al.

ACS Sustainable Chemistry & Engineering, Journal Year: 2024, Volume and Issue: 12(52), P. 18679 - 18690

Published: Dec. 16, 2024

Hydrogels are ideal lubricants due to their hydrophilicity and ability mitigate issues such as creep leakage. Based on the diversity of application environments, it is crucial develop hydrogels with adjustable lubrication that can adjust properties by changing in external environment. However, they still face challenges balancing responsiveness, efficacy, safety. This study presents a pH-responsive hydrogel prepared from polyvinylpyrrolidone phytic acid, addition MXene glycerol enhance its tribological performance. The optimal contents for peak efficiency found be 5 mg/mL wt %, respectively. lubricant maintain low-friction state without failure long-term testing 3 h, achieving coefficient friction (COF) 0.01. synergistic effect reached reduction 69% wear resistance improvement up 96%. Moreover, COF regulated adjusting pH value. also stands out robust self-healing, injectability, biocompatibility, making an excellent candidate advanced biomedical applications.

Language: Английский

Citations

1

Development of a pH‐Responsive Antimicrobial and Potent Antioxidant Hydrogel for Accelerated Wound Healing: A Game Changer in Drug Delivery DOI Open Access
Qixiang Gui, Neng Ding,

Haimei Wu

et al.

Advanced Biology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 14, 2024

Abstract Stimuli‐responsive hydrogels have the capability to alter their state in response changes physiological signals within application environment, providing distinct benefits drug delivery applications. Here, acidic pH typically found acutely infected wounds can be effectively managed by incorporating a pH‐responsive Ag + loaded system hydrogel, thereby ensuring efficient use and preventing potential toxicity from sudden release of silver ions. The antimicrobial composite hydrogel HAMA/GelMA‐CA/Ag provides some tissue adhesion accelerates wound healing. GelMA‐CA is synthesized modifying gelatin methacryloyl (GelMA) with caffeic acid (CA), while hyaluronic (HAMA) introduced prepare double network hydrogel. Silver nitrate then make it through formation coordination between polyphenolic structure exhibited excellent antioxidant properties strong activity against both Staphylococcus aureus (S. aureus) Escherichia coli (E. coli). Furthermore, accelerated promotion healing rat model S. aureus‐infected wounds. In conclusion, promising bioactive material that used as dressing promote

Language: Английский

Citations

0