Journal of Applied Polymer Science,
Journal Year:
2024,
Volume and Issue:
141(30)
Published: May 14, 2024
Abstract
Developing
antiswelling
hydrogel
that
retains
their
low
modulus
and
has
three‐dimensional
(3D)
printability
to
application
in
the
biomedical
field
is
a
current
critical
issue.
Here,
we
synthesized
3D
printing
ink
consist
of
poly(acrylic
acid‐acrylamide‐allyloxypolyethyleneglycol)
(P(AA‐Am‐APEG))
nanosilica
(SiO
2
)
by
free
radical
polymerization,
immersed
precursor
printed
ferric
chloride
solution
prepare
modulus,
antiswelling,
conductive
hydrogel.
In
physical
cross‐linking
network,
coordination
interaction
hydrogen
bonds
contributed
excellent
mechanical
properties
nSiO
regulated
rheological
behavior
ink.
Especially,
P(AA‐Am‐APEG)
molecular
chain
was
structure
containing
APEG
branch
chain,
which
could
endow
(the
equilibrium
swelling
rate
only
7%
deionized
water)
(Young's
less
than
100
kPa)
The
tensile
stress
still
maintain
90%
original
value
after
soaking
for
24
h.
addition,
existence
iron
ions
provided
high
sensitive
deformation‐dependent
conductivity
Therefore,
strategy
controlling
chains
would
expand
biosensors
other
fields.
ACS Applied Bio Materials,
Journal Year:
2023,
Volume and Issue:
6(9), P. 3683 - 3695
Published: Aug. 16, 2023
Granular
hydrogels
have
recently
emerged
as
promising
biomaterials
for
tissue
engineering
and
3D-printing
applications,
addressing
the
limitations
of
bulk
while
exhibiting
desirable
properties
such
injectability
high
porosity.
However,
their
structural
stability
can
be
improved
with
post-injection
interparticle
cross-linking.
In
this
study,
we
developed
granular
cross-linking
through
reversible
dynamic
covalent
bonds.
We
fragmented
photo-cross-linked
to
produce
aldehyde
or
hydrazide-functionalized
microgels
using
chondroitin
sulfate.
Mixing
these
facilitated
hydrazone
bonds,
providing
shear-thinning
self-healing
3D
printing.
The
resulting
displayed
mechanical
without
need
secondary
Furthermore,
porosity
sustained
release
growth
factors
from
synergistically
enhanced
cell
recruitment.
Our
study
highlights
potential
designing
injectable
printable
therapeutic
delivery
scaffolds
hydrogels.
Overall,
our
improve
hydrogels,
making
them
an
effective
biomaterial
use
in
applications.
Biomacromolecules,
Journal Year:
2024,
Volume and Issue:
25(9), P. 5889 - 5901
Published: Aug. 21, 2024
Hydrogels,
typically
favored
for
3D
printing
due
to
their
viscoelasticity,
are
now
trending
toward
ecofriendly
alternatives
amid
growing
environmental
concerns.
In
this
study,
we
crafted
cellulose-based
hydrogels,
specifically
employing
cellulose
acetate
sulfate
(CAS).
By
keeping
the
acetyl
group
substitution
degree
(DS
Advanced NanoBiomed Research,
Journal Year:
2023,
Volume and Issue:
3(3)
Published: Jan. 29, 2023
The
advancement
in
material
science
and
fabrication
techniques
has
led
to
the
booming
of
tissue
engineering
recent
years,
covering
culture,
repair,
regeneration,
rest.
Among
aforementioned,
considering
indispensable
roles
central/peripheral
nerve
soft
connective
tissues
playing
life‐sustaining
activities,
their
regenerations
have
attracted
intense
research
attention,
especially
using
polymeric
scaffolds,
an
easy‐to‐access,
cost
efficient,
biocompatible
diverse
family
materials.
Herein,
commonly
used
natural
synthetic
materials
for
scaffolds
are
outlined.
Specially,
polymer‐based
hybrids,
being
able
provide
both
structural
support
bio‐microenvironments,
discussed.
Additionally,
representative
manufacturing
approaches
including
freeze‐drying,
electrospinning,
3D
printing,
lithography
among
others
highlighted.
Notably,
combined
(e.g.,
etc.)
allowing
tailorable
configurations
composite
also
reviewed.
Furthermore,
achievements
discussed
detail.
In
end,
conclusions
outlooks
provided
draw
a
roadmap
future
research.
GEN Biotechnology,
Journal Year:
2022,
Volume and Issue:
1(4), P. 386 - 400
Published: Aug. 1, 2022
For
the
past
decade,
additive
manufacturing
has
resulted
in
significant
advances
toward
fabricating
anatomic-size
patient-specific
scaffolds
for
tissue
models
and
regenerative
medicine.
This
can
be
attributed
to
development
of
advanced
bioinks
capable
precise
deposition
cells
biomaterials.
The
combination
with
is
enabling
researchers
fabricate
intricate
that
recreate
complex
spatial
distributions
bioactive
cues
found
human
body.
However,
expansion
this
promising
technique
been
hampered
by
high
cost
commercially
available
bioprinters
proprietary
software.
In
contrast,
conventional
three-dimensional
(3D)
printing
become
increasingly
popular
home
hobbyists
caused
an
explosion
both
low-cost
thermoplastic
3D
printers
open-source
software
control
printer.
study,
we
bring
these
benefits
into
field
bioprinting
converting
widely
cost-effective
fully
functional,
open-source,
customizable
multihead
bioprinters.
These
utilize
computer
controlled
volumetric
extrusion,
allowing
a
wide
range
flow
properties
bioprinted,
including
non-Newtonian
bioinks.
We
demonstrate
practicality
approach
designing
customized
multiple
extruders,
automatic
bed
leveling,
temperature
controls
∼$400
USD.
were
then
used
vitro
ex
vivo
their
utility
engineering.
Journal of Applied Polymer Science,
Journal Year:
2024,
Volume and Issue:
141(30)
Published: May 14, 2024
Abstract
Developing
antiswelling
hydrogel
that
retains
their
low
modulus
and
has
three‐dimensional
(3D)
printability
to
application
in
the
biomedical
field
is
a
current
critical
issue.
Here,
we
synthesized
3D
printing
ink
consist
of
poly(acrylic
acid‐acrylamide‐allyloxypolyethyleneglycol)
(P(AA‐Am‐APEG))
nanosilica
(SiO
2
)
by
free
radical
polymerization,
immersed
precursor
printed
ferric
chloride
solution
prepare
modulus,
antiswelling,
conductive
hydrogel.
In
physical
cross‐linking
network,
coordination
interaction
hydrogen
bonds
contributed
excellent
mechanical
properties
nSiO
regulated
rheological
behavior
ink.
Especially,
P(AA‐Am‐APEG)
molecular
chain
was
structure
containing
APEG
branch
chain,
which
could
endow
(the
equilibrium
swelling
rate
only
7%
deionized
water)
(Young's
less
than
100
kPa)
The
tensile
stress
still
maintain
90%
original
value
after
soaking
for
24
h.
addition,
existence
iron
ions
provided
high
sensitive
deformation‐dependent
conductivity
Therefore,
strategy
controlling
chains
would
expand
biosensors
other
fields.
