Lanthanide-Doped ZnO Nanoparticles: Unraveling Their Role in Cytotoxicity, Antioxidant Capacity, and Nanotoxicology

Antioxidants, Journal Year: 2024, Volume and Issue: 13(2), P. 213 - 213

Published: Feb. 8, 2024

This study used a sonochemical synthesis method to prepare (La, Sm)-doped ZnO nanoparticles (NPs). The effect of incorporating these lanthanide elements on the structural, optical, and morphological properties ZnO-NPs was analyzed. cytotoxicity reactive oxygen species (ROS) generation capacity were evaluated against breast (MCF7) colon (HT29) cancer cell lines. Their antioxidant activity analyzed using DPPH assay, their toxicity towards Artemia salina nauplii also evaluated. results revealed that treatment with NPs resulted in death 10.559–42.546% 18.230–38.643% MCF7 HT29 cells, respectively. attributed ability downregulate ROS formation within two lines dose-dependent manner. In inhibited free radicals at IC50 values ranging from 3.898 126.948 μg/mL. Against A. nauplii, synthesized did not cause nor induce changes tested concentrations. A series machine learning (ML) models predict biological performance ZnO-NPs. Among designed ML models, gradient boosting model greatest mean absolute error (MAE) (MAE 9.027, R2 = 0.86). data generated this work provide innovative insights into influence La Sm structural arrangement chemical features ZnO-NPs, together cytotoxicity, activity, vivo toxicity.

Language: Английский

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Cytotoxic effects of NIR responsive chitosan-polymersome layer coated melatonin-upconversion nanoparticles on HGC27 and AGS gastric cancer cells: Role of the ROS/PI3K/Akt/mTOR signaling pathway

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 278, P. 134187 - 134187

Published: Aug. 3, 2024

Language: Английский

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Boosting Dye‐Sensitized Luminescence by Enhanced Short‐Range Triplet Energy Transfer

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(51)

Published: Aug. 11, 2023

Dye-sensitization can enhance lanthanide-based upconversion luminescence, but is hindered by interfacial energy transfer from organic dye to lanthanide ion Yb3+ . To overcome these limitations, modifying coordination sites on conjugated structures and minimizing the distance between fluorescence cores in nanoparticles (UCNPs) are proposed. The specially designed near-infrared (NIR) dye, disulfo-indocyanine green (disulfo-ICG), acts as antenna molecule exhibits a 2413-fold increase luminescence under 808 nm excitation compared UCNPs alone using 980 irradiation. significant improvement attributed high efficiency of 72.1% disulfo-ICG UCNPs, with majority originating triplet state (T1 ) disulfo-ICG. Shortening ions increases probability strengthens heavy atom effect, leading enhanced T1 generation improved dye-triplet sensitization upconversion. Importantly, this approach also applies 730 Cy7-SO3 system, overcoming spectral mismatch Cy7 achieving 52-fold enhancement luminescence. Furthermore, at single particle level through dye-sensitization demonstrated. This strategy expands range NIR dyes for opens new avenues highly efficient dye-sensitized systems.

Language: Английский

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Tricolor Upconversion Phosphors of LiYO₂:RE³⁺/Yb³⁺ (RE = Tm, Ho, Eu) for Metamerism Anti‐Counterfeiting and 3D Volumetric Display

Advanced Optical Materials, Journal Year: 2024, Volume and Issue: 12(11)

Published: Jan. 16, 2024

Abstract The development of blue/green/red tricolor upconversion (UC) phosphors under invisible light irradiation has attracted significant interest in emerging applications such as anti‐counterfeiting, three‐dimensional (3D) optical data storage, and solid‐state 3D displays. In this study, a series LiYO 2 :RE 3+ ,Yb (RE = Tm, Ho, Eu) are successfully prepared via first precipitation process followed by calcination, completely optimized for efficient UC luminescence with 980 nm laser excitation. Mechanisms involving two‐ or three‐photon absorption processes low‐phonon‐energy‐suppressed multi‐phonon relaxation have been proposed Ho (Eu )/Yb Tm /Yb codoping, respectively. addition, the RE (Yb ) concentration‐induced phase transition host is discussed interesting possibilities spectral regulation. Based on broad color gamut achieved phosphor mixture, homochromatic polychromatic metamerisms experimentally fabricated screen printing high‐level anti‐counterfeiting information security. Moreover, proof‐of‐concept demonstration, prototypes storage volumetric displays constructed embedding mixtures their printed patterns polydimethylsiloxane. It believed that continuous exploration excitation metamerism can promote security advanced display technologies.

Language: Английский

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Advances of NIR Light Responsive Materials for Diagnosis and Treatment of Brain Diseases

Advanced Optical Materials, Journal Year: 2023, Volume and Issue: 11(11)

Published: March 11, 2023

Abstract Brain diseases pose a great threat to human health worldwide, thus it is of importance explore new materials for their diagnosis and therapy. Compared with the ultraviolet (UV) visible light, near infrared (NIR) light has better biosafety, lower tissue auto‐fluorescence, stronger penetration into skull. Hence, NIR responsive have attracted attention recently which can not only realize high spatial resolution signal‐to‐noise ratio imaging diagnosis, but also achieve effective triggered treatment noninvasively. Besides, brain lesions be visualized clearly by imaging, provide more accurate information guiding treatments. Therefore, this work systematically summarizes recent advances diseases. Firstly, briefly reviews pathological features blood barrier (BBB) rational design target disease. Then, emerging approaches various are introduced. Subsequently, imaging‐guided therapies elaborated, such as fluorescence guided surgery sonodynamic Finally, some challenges prospects on precise therapy put forward.

Language: Английский

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Quantitative evaluation of various NIR-to-red upconversion mechanisms in NaYF4:20%Yb3+,2%Er3+ nanoparticles

Science China Materials, Journal Year: 2024, Volume and Issue: 67(10), P. 3115 - 3123

Published: Aug. 22, 2024

Language: Английский

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Development of Biocompatible, UV and NIR Excitable Nanoparticles with Multiwavelength Emission and Enhanced Colloidal Stability

ACS Materials Au, Journal Year: 2025, Volume and Issue: 5(2), P. 353 - 364

Published: Jan. 1, 2025

The development of functional nanoprobes for biomedical applications is highly important in the field modern nanotechnology. Due to strict requirements, such as ability be excited using irradiation, which allows deep tissue penetration, nonblinking behavior, and good optical colloidal stability, choice nanoparticles limited, their synthesis challenging. Among all purposes, upconverting nanoparticles, especially those with more complex architectures (e.g., core–shell or core–shell–shell), are most promising candidates. This study demonstrates advanced synthetic routes constructing biocompatible tunable properties stability. core–shell–shell architecture excitation from at least four sources, 272 394 nm near-ultraviolet (near-UV) irradiation 980 808 near-infrared (NIR) lasers. Furthermore, Gd-matrix-based doped lanthanide ions (Nd3+, Yb3+, Tm3+, Eu3+) known paramagnetic magnetic resonance imaging (MRI) well upconversion luminescence diverse emission bands across entire visible spectrum. feature desirable photodynamic therapy applications, proposed could overlap absorption band commonly used photosensitizers potentially result an efficient energy transfer process enhanced generation reactive oxygen species singlet oxygen.

Language: Английский

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Lanthanide‐Doped Nanomaterials for Luminescence Biosensing and Biodetection

Published: Jan. 3, 2025

This chapter provides a basic introduction to the luminescence characteristics of lanthanide-doped nanoparticles and design principles for optical bioprobes. Emphasis is placed on interface energy transfer process, which enables transduction biological signals into signals. The design, synthesis, surface functionalization are summarized, offering general method bioprobe preparation. A detailed review bioprobes various applications also presented. section aims showcase state-of-the-art biosensing biodetection technologies summarize methodology design. final part introduces integrated devices bioprobes, providing blueprint future point-of-care testing.

Language: Английский

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Unlocking Multimodal Nonlinear Microscopy for Deep‐Tissue Imaging under Continuous‐Wave Excitation with Tunable Upconverting Nanoparticles

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Nonlinear microscopy provides excellent depth penetration and axial sectioning for 3D imaging, yet widespread adoption is limited by reliance on expensive ultrafast pulsed lasers. This work circumvents such limitations employing rare-earth doped upconverting nanoparticles (UCNPs), specifically Yb3+/Tm3+ co-doped NaYF4 nanocrystals, which exhibit strong multimodal nonlinear optical responses under continuous-wave (CW) excitation. These UCNPs emit multiple wavelengths at UV (λ ≈ 450 nm), blue NIR 800 whose intensities are nonlinearly governed excitation power. Exploiting these properties, multi-colored emissions enable functional imaging of cerebral blood vessels in deep brain. Using a simple setup, high resolution vivo mouse cerebrovascular networks depths up to µmm achieved, surpassing performance conventional methods using CW In flow dynamics also visualized with wide-field video-rate low-powered Furthermore, depth-selective, 3D-localized photo-modulation through turbid media, presenting spatiotemporally targeted light beacons. innovative approach, leveraging UCNPs' intrinsic characteristics, significantly advances lasers, opening new opportunities bio-imaging, remote optogenetics, photodynamic therapy.

Language: Английский

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Near-Infrared-Responsive Semiconductor Quantum Dots for Solar Photocatalysis

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Language: Английский

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