Anthracene‐Based Endoperoxides as Self‐Sensitized Singlet Oxygen Carriers for Hypoxic‐Tumor Photodynamic Therapy

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 6, 2024

Abstract Singlet oxygen is a crucial reactive species (ROS) in photodynamic therapy (PDT). However, the hypoxic tumor microenvironment limits production of cytotoxic singlet through light irradiation PDT photosensitizers (PSs). This restriction poses major challenge improving effectiveness PDT. To overcome this challenge, researchers have explored development carriers that can capture and release physiological conditions. Among these developments, anthracene‐based endoperoxides, initially discovered almost 100 years ago, shown ability to generate controllably under thermal or photo stimuli. Recent advancements led new class self‐sensitized anthracene‐endoperoxides, with potential applications enhancing effects for tumors. review discusses current research progress utilizing anthracene‐endoperoxides as improved It covers anthracene‐conjugated small organic molecules, metal–organic complexes, polymeric structures, other nano‐structures. The molecular structural designs, mechanisms, characteristics systems will be discussed. aims provide valuable insights developing high‐performance hypoxic‐tumor

Language: Английский

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Chlorin e6: a promising photosensitizer of anti-tumor and anti-inflammatory effects in PDT

Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12

Published: Jan. 29, 2025

Photodynamic therapy (PDT) involves the activation of photosensitizers (PSs) by visible laser light at target site to catalyze production reactive oxygen species, resulting in tumor cell death and blood vessel closure. The efficacy PDT depends on PSs, amount oxygen, intensity excitation laser. PSs have been extensively researched, great efforts made develop an ideal photosensitizer. Chlorin-e6 is FDA-approved second-generation that has attracted widespread research interest medical field, especially with respect antitumor anti-inflammatory activity. possesses advantages a large absorption coefficient, high strength, low residue body, relatively safety thus promising application prospects. Here we review use chlorin-e6 discuss prospects further development this technology.

Language: Английский

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Singlet oxygen storage and controlled release for improving photodynamic therapy against hypoxic tumor

Chemical Communications, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

This feature article comprehensively summarizes the research progress related to strategy of singlet oxygen storage and its controlled release in photodynamic therapy dark or hypoxic tumors.

Language: Английский

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Unveiling the Impact of Light-Induced Acceptor-Generated ROS on Device Stability in Organic Photovoltaics

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(13), P. 16573 - 16579

Published: March 21, 2024

The intrinsic stability of the acceptor is a crucial component photovoltaic device stability. In this study, we investigated efficiency and nonfused-ring acceptors LC8 BC8 under indoor light conditions. Interestingly, found that devices based on with terminal side chains exhibited higher Through accelerated aging experiments, discovered generate singlet oxygen exposure demonstrating lower levels ROS compared to LC8. We attribute difference modulation aggregation orientation. Furthermore, generated reactive species (ROS) further deteriorate structure, phenomenon also observed in high-efficiency structures, such as Y6. Our research reveals important mechanisms photo-oxidation processes, providing theoretical basis for enhancing acceptors.

Language: Английский

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