Advanced Synthesis & Catalysis,
Journal Year:
2019,
Volume and Issue:
361(22), P. 5191 - 5197
Published: Sept. 30, 2019
Abstract
Homocoupling
of
weakly
coordinating
sulfoxonium
ylides
was
accomplished
via
ruthenium
(II)
catalyzed
C−H
activation
process.
This
strategy
provides
a
convenient,
efficient
and
step‐economic
method
to
access
3‐substituted
isocoumarins
with
good
functional
group
tolerance.
The
ylide
acts
both
as
the
convenient
aromatic
substrate
acylmethylation
reagent
in
this
transformation.
Moreover,
products
could
be
transformed
diverse
valuable
derivatives.
magnified
image
Frontiers in Chemistry,
Journal Year:
2023,
Volume and Issue:
11
Published: March 16, 2023
Quinazolines
are
a
class
of
nitrogen-containing
heterocyclic
compounds
with
broad-spectrum
pharmacological
activities.
Transition-metal-catalyzed
reactions
have
emerged
as
reliable
and
indispensable
tools
for
the
synthesis
pharmaceuticals.
These
provide
new
entries
into
pharmaceutical
ingredients
continuously
increasing
complexity,
catalysis
these
metals
has
streamlined
several
marketed
drugs.
The
last
few
decades
witnessed
tremendous
outburst
transition-metal-catalyzed
construction
quinazoline
scaffolds.
In
this
review,
progress
achieved
in
quinazolines
under
transition
metal-catalyzed
conditions
summarized
reports
from
2010
to
date
covered.
This
is
presented
along
mechanistic
insights
each
representative
methodology.
advantages,
limitations,
future
perspectives
through
such
also
discussed.
Chem,
Journal Year:
2024,
Volume and Issue:
10(7), P. 2283 - 2294
Published: July 1, 2024
Electrosynthesis
has
become
an
increasingly
popular
platform
in
modern
organic
chemistry,
possessing
distinctive
features
and
reaction
parameters
like
applied
current/potential,
electrodes,
electrolyte
systems,
cell
design.
While
these
unique
give
chemists
more
opportunities
to
control
reactivity
selectivity,
they
also
increase
the
dimensionalities
of
a
complicate
interactions
between
variables,
making
optimization
challenging.
Herein,
we
present
machine
learning
(ML)
workflow
that
leverages
physical
descriptor-based
yield
prediction
orthogonal
experimental
design
strike
delicate
balance
need
for
sampling
diversity
pursuit
improvements,
thereby
efficiently
identifying
ideal
conditions
enantioselective
palladaelectro-catalyzed
annulation
from
extensive
synthetic
space.
This
work
shows
potential
synergizing
electrochemistry
data-driven
approach
tackle
multidimensional
chemical
problems.
Chemical Communications,
Journal Year:
2019,
Volume and Issue:
55(50), P. 7251 - 7254
Published: Jan. 1, 2019
A
new
electrochemical
decarboxylative
[4+2]
annulation
of
arylglyoxylic
acids
with
internal
alkynes
involving
C-H
functionalization
by
means
a
cooperative
anode
and
ruthenium
catalysis
is
presented.
This
reaction
represents
mechanistically
novel
strategy
as
an
ideal
supplement
to
the
methodology
employing
electrooxidative
process
avoid
use
additional
external
oxidizing
reagent
utilizing
H2O
carboxyl
oxygen
atom
source
be
engaged
in
synthesis
1H-isochromen-1-ones.
Advanced Synthesis & Catalysis,
Journal Year:
2019,
Volume and Issue:
361(22), P. 5191 - 5197
Published: Sept. 30, 2019
Abstract
Homocoupling
of
weakly
coordinating
sulfoxonium
ylides
was
accomplished
via
ruthenium
(II)
catalyzed
C−H
activation
process.
This
strategy
provides
a
convenient,
efficient
and
step‐economic
method
to
access
3‐substituted
isocoumarins
with
good
functional
group
tolerance.
The
ylide
acts
both
as
the
convenient
aromatic
substrate
acylmethylation
reagent
in
this
transformation.
Moreover,
products
could
be
transformed
diverse
valuable
derivatives.
magnified
image
