Angewandte Chemie,
Journal Year:
2023,
Volume and Issue:
135(32)
Published: June 15, 2023
Abstract
We
disclose
a
Ni‐catalyzed
regioselective
dialkylation
reaction
of
alkenylarenes
with
α‐halocarbonyls
and
alkylzinc
reagents.
The
produces
γ‐arylated
alkanecarbonyl
compounds
the
generation
two
new
C(sp
3
)−C(sp
)
bonds
at
vicinal
carbons
alkenes.
This
is
effective
for
use
primary,
secondary
tertiary
α‐halocarboxylic
esters,
amides
ketones
in
conjunction
primary
reagents
as
sources
terminal
cyclic
internal
The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
89(1), P. 281 - 290
Published: Dec. 18, 2023
A
visible-light-driven
photoredox
dialkylation
of
styrenes
with
α-carbonyl
alkyl
bromides
and
pyridin-1-ium
salts
for
the
synthesis
polysubstituted
1,4-dihydropyridines
is
reported.
This
reaction
enables
formation
two
new
C(sp3)–C(sp3)
bonds
in
a
single
step
provides
strategy
that
employs
as
functionalized
alkylating
reagents
via
dearomatization
to
directly
trap
resulting
radicals
from
radical
addition
alkenes
then
terminate
alkene
dialkylation.
European Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
27(45)
Published: Aug. 28, 2024
Abstract
A
photocatalyst‐free
cascade
reaction
of
N
‐alkyl‐
‐arylmethacrylamides
with
monoalkyl
cesium
oxalate
salts
is
described.
In
the
presence
visible
light
and
(NH
4
)
2
S
O
8
,
undergo
single‐electron
oxidation/CO
extrusion
to
generate
alkyl
radicals,
followed
by
addition
subsequent
cyclization
give
alkylated
oxindoles.
addition,
‐methacryloylbenzamides
could
be
applied
for
reaction,
providing
a
series
isoquinolinediones,
which
are
completely
different
from
products
obtained
oxalates
as
substrates.
Advanced Synthesis & Catalysis,
Journal Year:
2023,
Volume and Issue:
365(24), P. 4527 - 4532
Published: Nov. 11, 2023
Abstract
A
photocatalytic
reaction
of
N‐alkyl‐N‐methacryloylbenzamides
with
monoalkyl
oxalates
is
described.
Monoalkyl
undergo
single‐electron
oxidation/CO
2
extrusion
to
generate
alkoxycarbonyl
radicals,
followed
by
the
addition
and
subsequent
cyclization
give
substituted
isoquinolinediones.
wide
variety
were
amenable
in
this
protocol,
affording
various
We
disclose
a
Ni-catalyzed
regioselective
dialkylation
reaction
of
alkenylarenes
with
-halocarbonyls
and
alkylzinc
reagents.
The
produces
-arylated
alkanecarbonyl
compounds
the
generation
two
new
C(sp3)-C(sp3)
bonds
at
vicinal
carbons
alkenes.
This
is
effective
for
use
primary,
secondary
tertiary
-halocarboxylic
esters,
amides
ketones
in
conjunction
primary
reagents
as
sources
C(sp3)
terminal
cyclic
internal
An
efficient
protocol
for
the
asymmetric
synthesis
of
unnatural
amino
acids
is
realized
through
photoredox-mediated
C–O
bond
activation
oxalate
esters
derived
from
aliphatic
alcohols
as
radical
precursors.
The
developed
system
uses
chiral
glyoxylate-derived
N-sulfinyl
imine
acceptor
and
allows
quick
access
to
a
range
functionalized
an
atom-economical
redox-neutral
process
with
CO2
only
stoichiometric
by-product.
Angewandte Chemie,
Journal Year:
2023,
Volume and Issue:
135(32)
Published: June 15, 2023
Abstract
We
disclose
a
Ni‐catalyzed
regioselective
dialkylation
reaction
of
alkenylarenes
with
α‐halocarbonyls
and
alkylzinc
reagents.
The
produces
γ‐arylated
alkanecarbonyl
compounds
the
generation
two
new
C(sp
3
)−C(sp
)
bonds
at
vicinal
carbons
alkenes.
This
is
effective
for
use
primary,
secondary
tertiary
α‐halocarboxylic
esters,
amides
ketones
in
conjunction
primary
reagents
as
sources
terminal
cyclic
internal
