Expeditious synthesis of CF3-phenanthridones through a base mediated cross-conjugated vinylogous benzannulation (VBA) DOI

Madhu Desagoni,

Chavakula Nagababu,

Nagender Punna

et al.

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Herein, we report a mild, efficient, and rapid approach for the preparation of CF

Language: Английский

CsCF3B(OMe)3: A Versatile Nucleophilic Source of the Trifluoromethyl Anion DOI

Aurélien Dupeux,

Andrew G. Durant,

Karolina Rabeda

et al.

Synthesis, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Abstract We have identified cesium trimethoxy(trifluoromethyl)borate [CsCF3B(OMe)3] as a nucleophilic source for the trifluoromethylation of carbonyl compounds. A differentiating characteristic CsCF3B(OMe)3 is its heightened reactivity in ethereal solvents compared to potassium analogue, which typically employed dimethylformamide. Also, contrast extensively studied Ruppert–Prakash reagent (TMSCF3), does not require addition an exogenous activator. Described herein, we detail synthesis and demonstrate efficacy across various scaffolds, including methyl ketones, isatin derivatives, 1,2-acyclic dicarbonyls.

Language: Английский

Citations

0
Access to CF3-benzofulvenes via palladium-catalyzed cascade arylation/Trost–Oppolzer cyclization/double-bond isomerization DOI

Rami Sateesh,

Jaggaraju Prudhviraj,

Chiliveru Priyanka

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(26), P. 3551 - 3554

Published: Jan. 1, 2024

Highly stereoselective synthesis of CF 3 -benzofulvenes has been achieved through a Pd-catalyzed cascade reaction involving three consecutive transformations such as arylation, Trost–Oppolzer type Alder-ene reaction, and double bond isomerization.

Language: Английский

Citations

3
Cross-conjugated vinylogous annulation of π-CF3-allyl Pd-complexes with 4-methyl-3-trifluoroacetyl-quinolones DOI

Chiliveru Priyanka,

Madhu Desagoni,

Palivela Siva Gangadhar

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

A hitherto unknown cross-conjugated vinylogous anionic annulation of π-CF 3 -allyl Pd-complexes with 4-methyl-3-trifluoroacetyl quinolones has been disclosed to access the diversely functionalized phenanthridones.

Language: Английский

Citations

1
Pd-catalyzed double Heck and Heck–Suzuki cascade reaction of N-(o-bromo aryl) CF3-acrylamides DOI
Ruchi Sharma, Naveen Sihag, Hemaang Bhartiya

et al.

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(6), P. 1736 - 1741

Published: Jan. 1, 2024

A double Heck and Heck–Suzuki cascade approach using Pd catalyst yields trifluoromethyl-tethered 3,3-disubstituted oxindoles from N -( o -bromoaryl) trifluoromethyl acrylamide with alkenes/phenylboronic acids.

Language: Английский

Citations

0
Expeditious synthesis of CF3-phenanthridones through a base mediated cross-conjugated vinylogous benzannulation (VBA) DOI

Madhu Desagoni,

Chavakula Nagababu,

Nagender Punna

et al.

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Herein, we report a mild, efficient, and rapid approach for the preparation of CF

Language: Английский

Citations

0