Organic & Biomolecular Chemistry,
Journal Year:
2023,
Volume and Issue:
21(48), P. 9524 - 9529
Published: Jan. 1, 2023
An
eco-friendly
and
metal-free
method
for
the
synthesis
of
tetrahydrodibenzo[b,g][1,8]naphthyridin-1(2H)-ones
was
established.
Quinoline-derived
dipolarophiles
cyclic
enaminones
as
starting
materials
undergo
a
1,4-Michael
addition/SNAr
tandem
annulation
reaction
affording
target
products.
This
approach
features
transition
conditions,
good
functional
group
tolerance
operational
simplicity.
Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(10), P. 2363 - 2369
Published: March 16, 2024
Abstract
A
synthetic
protocol
was
developed
to
synthesize
highly
functionalized
3‐furylmethyl
chromones
from
enynones
and
o
‐hydroxyphenyl
enaminones
via
silver‐catalyzed
cascade
bis‐heteroannulation
reaction.
This
strategy
features
broad
substrate
scope
good
functional
group
tolerance.
Furthermore,
the
chromone
skeleton
shows
potential
application
value
through
further
gram‐scale
synthesis
derivatization.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 27, 2025
By
means
of
simple
Rh
catalysis,
the
direct
activation
ortho-C-H
bond
in
aryl
enaminones
has
been
realized
with
enaminone
structure
as
a
traceless
directing
fragment.
The
products
resulting
from
C-H
alkenylation
and
further
annulation
via
intramolecular
addition
could
be
accessed
depending
upon
alkenes.
annulated
used
for
easy
synthesis
valuable
2-aza-fluorenones
one-pot
operation
by
employing
NH4OAc.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(12), P. 8521 - 8530
Published: June 3, 2024
An
oxidative
free-radical
C(sp2)–H
bond
chlorination
strategy
of
enaminones
has
been
developed
by
using
LiCl
as
a
chlorinating
reagent
and
K2S2O8
an
oxidant.
This
transformation
provides
new
straightforward
synthetic
methodology
to
afford
highly
functionalized
α-chlorinated
with
Z-configuration
in
good
excellent
yields.
The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
88(16), P. 11627 - 11636
Published: Aug. 9, 2023
Syntheses
of
highly
functionalized
4-alkylated
1,4-dihydropyridines
(1,4-DHPs)
from
cyclic
ethers
and
enaminones
via
iron(II)-mediated
oxidative
free
radical
cascade
C(sp3)-H
bond
functionalization/C(sp3)-O
cleavage/cyclization
reaction
have
been
first
developed.
This
novel
synthetic
strategy
offers
an
alternative
method
for
the
construction
1,4-DHPs
by
using
esters
as
C4
sources,
well
expands
application
in
heterocycle
synthesis.
Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(19), P. 4139 - 4144
Published: July 2, 2024
Abstract
A
copper‐catalyzed
annulation
of
enaminones
with
maleimides
was
developed
to
synthesize
various
pyrrolo[3,4‐e]isoindoles.
In
this
strategy,
2‐aminopyridine
served
as
a
traceless
directing
group,
and
target
products
were
obtained
in
54–72%
yields.
Moreover,
plausible
mechanism
for
reaction
proposed
based
on
several
control
experiments,
deuterium
exchange
previous
reports.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 11, 2025
A
new
approach
to
multifunctionalized
pyrroles
has
been
explored
by
the
tandem
cyclization
of
α-oxoketene-N,S-acetals
with
β-ketodinitriles
using
Cu(MeCN)4BF4
and
Ag2CO3
in
toluene
under
reflux
conditions.
The
reaction
involves
C–C/C–N
bond
creation,
is
assumed
proceed
via
enamine
formation,
intramolecular
cyclization,
rearrangement.
potential
methodology
also
demonstrated
for
a
gram-scale
as
well
some
useful
organic
transformations.
offers
practical
pathway
achieve
polysubstituted
broad
substrate
scope
good
functional
group
tolerance.
ChemistrySelect,
Journal Year:
2025,
Volume and Issue:
10(18)
Published: May 1, 2025
Abstract
A
facile
Cu(II)‐catalyzed
annulation
of
o
‐phenylenediamine
and
phenacyl
bromides
in
EtOH
has
been
developed.
In
this
protocol,
diverse
2‐functionalized
quinoxalines
were
prepared
74%–91%
yields
with
high
chemoselectivity.
The
salient
features
are
the
excellent
yields,
broad
substrate
scope,
mild
reaction
conditions,
large‐scale
preparation.
This
not
only
fills
gap
conventional
metal‐catalyzed
o‐phenylenediamine
but
also
provides
a
practical
strategy
for
construction
quinoxalines.
