Copper-Catalyzed Trifluoromethylthiolaton and Radical Cyclization of N-Phenylpent-4-Enamides to Construct SCF3-Substituted γ-Lactams DOI Open Access
Hanyang Zhang, Wen Liu, Jinjun Hu

et al.

Catalysts, Journal Year: 2024, Volume and Issue: 14(11), P. 797 - 797

Published: Nov. 7, 2024

An efficient method involving copper-catalyzed trifluoromethylthiolation and radical cyclization of N-phenylpent-4-enamides using readily available stable AgSCF3 as the trifluoromethylthiolating reagent is described. The enables synthesis a series potential medicinally valuable trifluoromethylthio-substituted γ-lactams relative 2-oxazolidinone derivatives with broad functional group compatibility. Mechanistic investigations indicated that this reaction involved amidyl radical-initiated cascade 5-exo-trig followed by trifluoromethylthiolation, resulting in formation new C-N C-S bonds.

Language: Английский

Visible-Light-Induced Tandem Reaction of Quinoxalin-2(1H)-ones, Alkenes, and Sulfonyl Chlorides DOI
Yaru Lu, Meng Li, Qianqian Feng

et al.

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: 22(33), P. 6799 - 6809

Published: Jan. 1, 2024

A visible-light-induced tandem reaction involving quinoxalin-2(1

Language: Английский

Citations

5
Recent advancements in visible-light-induced direct C(3)–H functionalization of quinoxalin-2(1H)-ones DOI Creative Commons

Xin Han,

Yifan Guo, Y. Hu

et al.

Green Synthesis and Catalysis, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Citations

3
Visible-Light Induced Iron-Catalyzed Hydroxymethylation of N-Heterocycles DOI
Yan‐Hua Fu,

Chang Xu,

Chao Zhang

et al.

Chinese Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 44(7), P. 2265 - 2265

Published: Jan. 1, 2024

Language: Английский

Citations

1
Electrochemical Trifluoromethylthiolation/Cyclization of N-Arylacrylamides with AgSCF3: Access to SCF3-Containing Oxindoles DOI
Yu Wang, Ye Wang, Sheng Wang

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(17), P. 11950 - 11958

Published: Aug. 19, 2024

An environmentally friendly electrochemical strategy for the synthesis of SCF3-containing oxindoles was developed. This transformation accomplished through a cascade trifluoromethylthiolation/cyclization N-acrylamides with AgSCF3, obviating requirement external oxidants. A variety functional groups were well tolerated in this transformation.

Language: Английский

Citations

1
Silver-Mediated Radical Cascade Trifluoromethylthiolation/Cyclization of Benzimidazole Derivatives with AgSCF3 DOI
Pan Liu, Yang Geng,

Dapeng Zou

et al.

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

A silver-mediated cascade trifluoromethylthiolation/cyclization of unactivated alkenes has been investigated. This strategy employs AgSCF

Language: Английский

Citations

1
Copper-Catalyzed Trifluoromethylthiolaton and Radical Cyclization of N-Phenylpent-4-Enamides to Construct SCF3-Substituted γ-Lactams DOI Open Access
Hanyang Zhang, Wen Liu, Jinjun Hu

et al.

Catalysts, Journal Year: 2024, Volume and Issue: 14(11), P. 797 - 797

Published: Nov. 7, 2024

An efficient method involving copper-catalyzed trifluoromethylthiolation and radical cyclization of N-phenylpent-4-enamides using readily available stable AgSCF3 as the trifluoromethylthiolating reagent is described. The enables synthesis a series potential medicinally valuable trifluoromethylthio-substituted γ-lactams relative 2-oxazolidinone derivatives with broad functional group compatibility. Mechanistic investigations indicated that this reaction involved amidyl radical-initiated cascade 5-exo-trig followed by trifluoromethylthiolation, resulting in formation new C-N C-S bonds.

Language: Английский

Citations

0