Design, Synthesis, and Antimicrobial Activity of Amide Derivatives Containing Cyclopropane DOI Creative Commons
Dongdong Chen, Yu Cheng,

Lele Shi

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(17), P. 4124 - 4124

Published: Aug. 30, 2024

As an important small organic molecule, cyclopropane is widely used in drug design. In this paper, fifty-three amide derivatives containing were designed and synthesized by introducing groups aryl into through the active splicing method, their antibacterial antifungal activities evaluated vitro. Among them, thirty-five compounds new compounds, eighteen known (F14, F15, F18, F20–F26, F36, F38–F44). Bioassay results disclosed that four, three, nine of showed moderate activity against Staphylococcus aureus, Escherichia coli, Candida albicans, respectively. Three sensitive to with excellent (MIC80 = 16 μg/mL). The molecular docking show F8, F24, F42 have good affinity potential target CYP51 protein.

Language: Английский

Synthesis of Difluorocyclopropanes via a Photoinduced [1＋2] Cycloaddition of Diazo Esters with gem-Difluoroalkenes DOI

Xiaonan Mu,

Mingyu Guan, Yongsheng Niu

et al.

Chinese Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: 45(1), P. 256 - 256

Published: Jan. 1, 2025

Language: Английский

Citations

0
Pd-Catalyzed Domino Heck Cyclization/Cross-coupling of Indoles with β-Chlorovinyl Ketones: Synthesis of Antifungal Active Furan-bearing Indolo[2,1-α]isoquinolines DOI

Yongqi Bai,

Xingrui Qi,

Hanjing Li

et al.

Organic & Biomolecular Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

The reaction enabling the rapid construction of three bonds to form furan-bearing indolo[2,1- α ]isoquinolines, which exhibit certain antifungal activity in vitro , is presented.

Language: Английский

Citations

0
Visible-Light-Driven gem-Difluorocyclopropanation of gem-Difluoroalkenes with Diazo Compounds DOI

Xinxin Han,

Xin Liu, Christophe Len

et al.

Tetrahedron, Journal Year: 2025, Volume and Issue: unknown, P. 134653 - 134653

Published: April 1, 2025

Language: Английский

Citations

0
Design, Synthesis, and Antimicrobial Activity of Amide Derivatives Containing Cyclopropane DOI Creative Commons
Dongdong Chen, Yu Cheng,

Lele Shi

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(17), P. 4124 - 4124

Published: Aug. 30, 2024

As an important small organic molecule, cyclopropane is widely used in drug design. In this paper, fifty-three amide derivatives containing were designed and synthesized by introducing groups aryl into through the active splicing method, their antibacterial antifungal activities evaluated vitro. Among them, thirty-five compounds new compounds, eighteen known (F14, F15, F18, F20–F26, F36, F38–F44). Bioassay results disclosed that four, three, nine of showed moderate activity against Staphylococcus aureus, Escherichia coli, Candida albicans, respectively. Three sensitive to with excellent (MIC80 = 16 μg/mL). The molecular docking show F8, F24, F42 have good affinity potential target CYP51 protein.

Language: Английский

Citations

2