Regioselective construction of 2-substituted indolines enabled by a rhodium-catalyzed decarboxylation–hydroacylation sequence

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(19), P. 5495 - 5501

Published: Jan. 1, 2024

Rhodium( i )-catalyzed sequential decarboxylation and hydroacylation of vinyl benzoxazinanones with chelating aldehydes for the highly regioselective synthesis 2-substituted indolines via a new η 2 -Rh complex has been developed.

Language: Английский

Recent Progress in Metal‐Free Hydroacylation Reactions of Alkenes and Alkynes

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(35)

Published: Sept. 12, 2024

Abstract The present review discusses the development of new metal‐free conditions for hydroacylation alkenes and alkynes under both thermal photochemical from 2018, their application to synthesis various bioactive molecules over past few years. key point highlights remarkable progress made by catalytic systems in comparison conventional metal catalysts alkenes, alkynes, arenes. Both inter‐ intramolecular reactions mechanistic pathways were discussed. most current developments several natural, pharmaceutical, heterocyclic compounds using have also been introduced.

Language: Английский

Ligand‐Controlled Regioselective Hydroacylation Reactions of Methylenecyclobutanes under Rhodium Catalysis

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(40)

Published: Oct. 1, 2024

Abstract In this study, we report a Rh(I)/dppf catalytic system that can tune the regioselectivity of methylenecyclobutanes. Under optimal reaction conditions, series 1,3‐disubstituted cyclobutanes were prepared in high yields (up to 95%) with excellent (>20:1 r.r.). Scale‐up synthesis cyclobutane product at low catalyst loading (2 mol%) demonstrates robustness dppf‐controlled hydroacylation.

Language: Английский