The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 4, 2024
Here
we
report
a
strategy
that
eliminates
the
need
for
photocatalysts
and
external
additives,
which
provides
an
operable
mild
method
halogen
radical-enabled
dearomatization
of
N-arylpropiolamides
under
oxygen
atmosphere
at
room
temperature.
The
is
applicable
to
wide
range
substrates,
extending
beyond
limited
scope
p-methoxyl
N-phenylpropynamides.
Furthermore,
several
functional
synthetic
intermediates
anticancer
bioactive
molecules
were
successfully
derived
from
3-halogenated
azaspiro[4.5]trienones.
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(15), P. 4318 - 4342
Published: Jan. 1, 2024
This
review
primarily
focuses
on
the
generation
of
aryl
radicals
via
an
electroreduction
strategy,
and
systematically
elaborates
synthetic
applications,
scope,
limitations
substrates.
Chemistry - A European Journal,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 16, 2024
The
advancement
in
electrochemical
techniques
has
unlocked
a
new
path
for
achieving
unprecedented
oxidations
and
reductions
of
aryl
radical
precursors
controlled
selective
manner.
This
approach
facilitates
the
construction
aromatic
carbon-carbon
carbon-heteroatom
bonds.
In
light
green
merits
growing
importance
this
technique
chemistry,
review
aims
to
provide
an
overview
recent
advance
generation
radicals
organized
by
precursor
type,
with
focus
on
substrate
scope,
limitation,
underlying
mechanism,
thereby
inspiring
future
work
generation.
ACS Omega,
Journal Year:
2025,
Volume and Issue:
10(6), P. 5778 - 5794
Published: Feb. 3, 2025
Globally,
breast
cancer
is
the
leading
cause
of
mortality.
Within
field
antibreast
drug
design
by
several
compound
docking
studies,
eight
new
N-containing
nonsteroid
tetracyclic
derivatives
have
been
synthesized
via
regioselective
intramolecular
C-H
functionalization
visible
light.
The
adopted
methodology
highly
efficient,
green,
and
sustainable
to
unload
a
pathway
with
excellent
yield.
It
offers
rapid,
low-cost,
catalyst-free
method
for
creating
physiologically
active
molecules
from
easily
accessible
substrates.
substances
were
described
using
spectroscopic
methods
like
HRMS,
1HNMR,
13CNMR,
XRD
analysis.
This
study
explores
cytotoxic
potential
novel
compounds
against
human
MCF-7
cells.
includes
in
vitro
experiments
assess
effect
our
on
These
include
cytotoxicity
assessment
cell
cycle,
apoptosis,
MTT
test
analysis
flow
cytometry,
reactive
oxygen
species
(ROS)
production
assessment,
etc.
Among
compounds,
2e
exhibited
most
potent
activity,
an
inhibitory
concentration
(IC50)
40
nM,
surpassing
efficacy
established
drugs
such
as
exemestane
(IC50
24.97
micromolar)
tamoxifen
5.45
μM).
Compound
also
significantly
induced
apoptosis
cycle
arrest
G1
phase,
increasing
apoptotic
population
65.97%.
Additionally,
led
marked
rise
level
ROS
generation,
implicating
oxidative
stress
its
mechanism
action.
Molecular
dynamic
simulation
further
supported
vigorous
anticancer
activity
2e,
demonstrating
promise
effective
treatment.
Catalysis Science & Technology,
Journal Year:
2024,
Volume and Issue:
14(18), P. 5143 - 5160
Published: Jan. 1, 2024
This
review
article
summarizes
the
visible
light
mediated
synthesis
of
allenes
from
substrates
like
1,3-enynes,
propargylic
carbonates,
homopropargylic
alcohols,
oxalates,
alkynyl
diazo
compounds,
and
terminal
aziridines.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(37), P. 25552 - 25561
Published: Sept. 5, 2024
The
synthesis
of
complex
polysubstituted
aromatic
molecules
from
simple
precursors
is
a
central
goal
in
organic
chemistry.
In
this
study,
we
developed
an
approach
for
the
The
synthesis
of
complex
polysubstituted
aromatic
molecules
from
simple
precursors
is
a
central
goal
in
organic
chemistry.
In
this
study,
we
developed
an
approach
for
the
ortho-alkylation
iodoarenes
utilizing
dual
ligand
catalytic
system.
By
combining
Pd/olefin
cooperative
catalysis
with
bulky
trialkylphosphine
ligand-promoted
C(sp2)-I
reductive
elimination,
have
established
ortho-alkylative
Catellani-type
reaction
aryl-iodine
bond
reconstruction
as
final
step,
which
opens
new
synthetic
opportunities
within
reactions.
Through
in-depth
mechanistic
investigations,
isolated
and
characterized
key
organopalladium
intermediates,
revealing
synergistic
interaction
ligands
merging
process
elimination.
present
study
showcases
unique
advantages
emphasizes
effectiveness
system
expanding
chemical
space
Catellani
Aryl-chlorides
and
-fluorides
are
common
building
blocks,
but
their
use
in
synthesis
is
limited
by
the
high
stability
of
Ar-X
bonds.
The
generation
aryl
radicals
via
activation
strong
bonds
possible
through
irradiation
tailor-made
organic
anions,
which
become
reductants
stronger
than
lithium
metal.
We
report
that
combination
visible
light
with
cheap
diphenylacetic
acid
dianion
an
even
better
tool,
showing
excellent
activity
across
a
variety
complex
substrates
providing
opportunities
for
late-stage
drug
modification.
chemoselectively
activated
presence
more
easily
reducible
functions,
such
as
Alk-Cl
ones
carbonyl
groups,
reminding
Marcus
inverted
region
principle.
These
results
pave
way
to
original
synthetic
strategies
would
be
otherwise
considered
impossible
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(20), P. 15164 - 15169
Published: Oct. 7, 2024
An
I2-mediated
annulation
of
3-aminopyrazoles
with
indole-3-carboxaldehydes
has
been
demonstrated
for
the
first
time.
This
tandem
strategy
allows
facile
construction
indole-pyrimidine-pyrazole-fused
tetracyclic
heteroarenes
that
are
otherwise
inaccessible
by
existing
methods.
These
fused
heterocycles
exhibited
enhanced
antifungal
activities
against
Valsa
mali
and
Botryosphaeria
dothidea
compared
commercial
Xemium
fungicide.
Chemistry - A European Journal,
Journal Year:
2024,
Volume and Issue:
31(8)
Published: Oct. 27, 2024
Abstract
Aryl‐chlorides
and
‐fluorides
are
common
building
blocks,
but
their
use
in
synthesis
is
limited
by
the
high
stability
of
Ar−X
bonds.
The
generation
aryl
radicals
via
activation
strong
bonds
possible
through
irradiation
tailor‐made
organic
anions,
which
become
reductants
stronger
than
lithium
metal.
We
report
that
combination
visible
light
with
cheap
diphenylacetic
acid
dianion
an
even
better
tool,
showing
excellent
activity
across
a
variety
complex
substrates
providing
opportunities
for
late‐stage
drug
modification.
chemoselectively
activated
presence
more
easily
reducible
functions,
such
as
Alk‐Cl
ones
carbonyl
groups.
These
results
pave
way
to
original
synthetic
strategies
would
be
otherwise
considered
impossible.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 25, 2024
An
electrochemical
protocol
for
the
alkylthiolation
of
aryl
halides
was
developed.
By
using
dialkyl
disulfides
as
alkylthio
sources,
Mg
plate
sacrificial
anode
and
graphite
felt
(GF)
cathode,
a
series
sulfides
were
obtained
in
moderate
to
good
yields.
The
approach
also
suitable
synthesis
selenides.
This
method
has
features
such
simple
reaction
conditions
functional
group
compatibility,
which
makes
it
have
application
prospect
organic
drug
synthesis.
