Versatile Polydopamine Platforms: Synthesis and Promising Applications for Surface Modification and Advanced Nanomedicine

ACS Nano, Journal Year: 2019, Volume and Issue: 13(8), P. 8537 - 8565

Published: Aug. 1, 2019

As a mussel-inspired material, polydopamine (PDA), possesses many properties, such as simple preparation process, good biocompatibility, strong adhesive property, easy functionalization, outstanding photothermal conversion efficiency, and quenching effect. PDA has attracted increasingly considerable attention because it provides versatile approach to functionalize material surfaces for obtaining variety of multifunctional nanomaterials. In this review, recent significant research developments including its synthesis polymerization mechanism, physicochemical different nano/microstructures, diverse applications are summarized discussed. For the sections in surface modification biomedicine, we mainly highlight achievements past few years (2016–2019). The remaining challenges future perspectives PDA-based nanoplatforms discussed rationally at end. This timely overall review should be desirable wide range scientists facilitate further development coating methods production materials.

Language: Английский

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Metal–Organic Frameworks for Biomedical Applications

Small, Journal Year: 2020, Volume and Issue: 16(10)

Published: Feb. 6, 2020

Metal-organic frameworks (MOFs) are an interesting and useful class of coordination polymers, constructed from metal ion/cluster nodes functional organic ligands through bonds, have attracted extensive research interest during the past decades. Due to unique features diverse compositions, facile synthesis, easy surface functionalization, high areas, adjustable porosity, tunable biocompatibility, MOFs been widely used in hydrogen/methane storage, catalysis, biological imaging sensing, drug delivery, desalination, gas separation, magnetic electronic devices, nonlinear optics, water vapor capture, etc. Notably, with rapid development synthetic methods functionalization strategies, smart MOF-based nanocomposites advanced bio-related properties designed fabricated meet growing demands MOF materials for biomedical applications. This work outlines synthesis recent advances fields, including cargo (drugs, nucleic acids, proteins, dyes) delivery cancer therapy, bioimaging, antimicrobial, biosensing, biocatalysis. The prospects challenges field also discussed.

Language: Английский

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Self-assembled single-atom nanozyme for enhanced photodynamic therapy treatment of tumor

Nature Communications, Journal Year: 2020, Volume and Issue: 11(1)

Published: Jan. 17, 2020

Hypoxia of solid tumor compromises the therapeutic outcome photodynamic therapy (PDT) that relies on localized O2 molecules to produce highly cytotoxic singlet oxygen (1O2) species. Herein, we present a safe and versatile self-assembled PDT nanoagent, i.e., OxgeMCC-r single-atom enzyme (SAE), consisting ruthenium as active catalytic site anchored in metal-organic framework Mn3[Co(CN)6]2 with encapsulated chlorin e6 (Ce6), which serves catalase-like nanozyme for generation. Coordination-driven self-assembly organic linkers metal ions presence biocompatible polymer generates nanoscale network adaptively encapsulates Ce6. The resulted SAE possesses well-defined morphology, uniform size distribution high loading capacity. When conducting situ generation through reaction between endogenous H2O2 Ru species SAE, hypoxia microenvironment is relieved. Our study demonstrates promising efficient sites cancer treatment.

Language: Английский

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The recent progress on metal–organic frameworks for phototherapy

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(8), P. 5086 - 5125

Published: Jan. 1, 2021

Some infectious or malignant diseases such as cancers are seriously threatening the health of human beings all over world. The commonly used antibiotic therapy cannot effectively treat these within a short time, and also bring about adverse effects drug resistance immune system damage during long-term systemic treatment. Phototherapy is an emerging antibiotic-free strategy to diseases. Upon light irradiation, phototherapeutic agents can generate cytotoxic reactive oxygen species (ROS) induce temperature increase, which leads death targeted cells. These two kinds killing strategies referred photodynamic (PDT) photothermal (PTT), respectively. So far, many photo-responsive have been developed. Among them, metal-organic framework (MOF) becoming one most promising materials because its structure chemical compositions be easily modulated achieve specific functions. MOFs intrinsic ability under rational design MOF construction, serve carrier therapeutic agents, owing tunable porosity. provide feasibility for various combined therapies targeting methods, improves efficiency phototherapy. In this review, we firstly investigated principles phototherapy, comprehensively summarized recent advances in PDT, PTT synergistic therapy, from construction modification. We expect that our demonstration will shed on future development field, it step closer clinical trials.

Language: Английский

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Recent advances in nanomaterials for enhanced photothermal therapy of tumors

Nanoscale, Journal Year: 2018, Volume and Issue: 10(48), P. 22657 - 22672

Published: Jan. 1, 2018

Recent advances in nanomaterials for enhanced therapeutic efficacy of photothermal therapy tumor treatment were highlighted.

Language: Английский

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A Mesoporous Nanoenzyme Derived from Metal–Organic Frameworks with Endogenous Oxygen Generation to Alleviate Tumor Hypoxia for Significantly Enhanced Photodynamic Therapy

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(27)

Published: May 16, 2019

Tumor hypoxia compromises the therapeutic efficiency of photodynamic therapy (PDT) as local oxygen concentration plays an important role in generation cytotoxic singlet (1 O2 ). Herein, a versatile mesoporous nanoenzyme (NE) derived from metal-organic frameworks (MOFs) is presented for situ endogenous to enhance PDT efficacy under bioimaging guidance. The NE constructed by first coating manganese-based MOFs with silica, followed facile annealing process ambient atmosphere. After removing silica shell and post-modifying polydopamine poly(ethylene glycol) improving biocompatibility, obtained loaded chlorin e6 (Ce6), commonly used photosensitizer PDT, high loading capacity. Upon through catalytic reaction between amount H2 , hypoxic tumor microenvironment relieved. Thus, Ce6-loaded serves -activated supplier increase significantly enhanced antitumor vitro vivo. In addition, also shows T2 -weighted magnetic resonance imaging ability its vivo tracking. This work presents interesting biomedical use MOF-derived multifunctional theranostic agent cancer therapy.

Language: Английский

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Nanoparticles modified by polydopamine: Working as “drug” carriers

Bioactive Materials, Journal Year: 2020, Volume and Issue: 5(3), P. 522 - 541

Published: April 18, 2020

Inspired by the mechanism of mussel adhesion, polydopamine (PDA), a versatile polymer for surface modification has been discovered. Owing to its unique properties like extraordinary adhesiveness, excellent biocompatibility, mild synthesis requirements, as well distinctive drug loading approach, strong photothermal conversion capacity and reactive oxygen species (ROS) scavenging facility, various PDA-modified nanoparticles have desired carriers. These with diverse nanostructures are exploited in multifunctions, consisting targeting, imaging, chemical treatment (CT), photodynamic therapy (PDT), (PTT), tissue regeneration ability, therefore attracted great attentions plenty biomedical applications. Herein, recent progress nanoparticle carriers cancer therapy, antibiosis, prevention inflammation, theranostics, vaccine delivery adjuvant, repair implant materials reviewed, including preparation their strategies, basic roles PDA modification, etc. The advantages overcoming existing limitations developing trends future also discussed.

Language: Английский

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A Mn(III)-Sealed Metal–Organic Framework Nanosystem for Redox-Unlocked Tumor Theranostics

ACS Nano, Journal Year: 2019, Volume and Issue: 13(6), P. 6561 - 6571

Published: May 28, 2019

Here, a Mn(III)-sealed metal–organic framework (MOF) nanosystem based on coordination between Mn(III) and porphyrin (TCPP) via one-pot method was designed constructed. Mn(III), as sealer, not only quenched TCPP-based fluorescence but also inhibited reactive oxygen species (ROS) generation, which made MOFs an "inert" theranostic nanoparticle. Interestingly, upon endocytosis by tumor cells, were disintegrated into Mn(II) free TCPP intracellular glutathione (GSH) in owing to redox reaction GSH. This disintegration would lead consumption of antioxidant GSH activated Mn(II)-based magnetic resonance imaging (MRI) well fluorescent imaging. More importantly, such GSH-regulated release could implement controllable ROS generation under irradiation, avoided side effects (inflammation damage normal tissues). As consequence, after unlocking GSH, significantly improve the therapeutic efficiency photodynamic therapy combining controlled depletion precise dual homing.

Language: Английский

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Phenolic-enabled nanotechnology: versatile particle engineering for biomedicine

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(7), P. 4432 - 4483

Published: Jan. 1, 2021

Phenolics are ubiquitous in nature and have gained immense research attention because of their unique physiochemical properties widespread industrial use. In recent decades, accessibility, versatile reactivity, relative biocompatibility catalysed phenolic-enabled nanotechnology (PEN) particularly for biomedical applications which been a major benefactor this emergence, as largely demonstrated by polydopamine polyphenols. Therefore, it is imperative to overveiw the fundamental mechanisms synthetic strategies PEN state-of-the-art provide timely comprehensive summary. review, we will focus on principles involved summarize use toolkit particle engineering bottom-up synthesis nanohybrid materials. Specifically, discuss attractive forces between phenolics complementary structural motifs confined systems synthesize high-quality products with controllable size, shape, composition, well surface chemistry function. Additionally, phenolic's numerous biosensing, bioimaging, disease treatment be highlighted. This review aims guidelines new scientists field serve an up-to-date compilation what has achieved area, while offering expert perspectives PEN's translational research.

Language: Английский

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Polydopamine-coated nucleic acid nanogel for siRNA-mediated low-temperature photothermal therapy

Biomaterials, Journal Year: 2020, Volume and Issue: 245, P. 119976 - 119976

Published: March 16, 2020

Language: Английский

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