Solutions to the Drawbacks of Photothermal and Photodynamic Cancer Therapy

Advanced Science, Journal Year: 2021, Volume and Issue: 8(3)

Published: Jan. 5, 2021

Phototherapy such as photothermal therapy and photodynamic in cancer treatment has been developed quickly over the past few years for its noninvasive nature high efficiency. However, there are still many drawbacks phototherapy that prevent it from clinical applications. Thus, scientists have designed different systems to overcome issues associated with phototherapy, including enhancing targeting ability of low-temperature therapy, replacing near-infrared light other excitation sources, so on. This article discusses problems shortcomings encountered development highlights possible solutions address them may become a useful approach practice. aims give brief summary about current research advancements provides quick guideline toward future developments field.

Language: Английский

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Metal–Organic Framework Derived Nanozymes in Biomedicine

Accounts of Chemical Research, Journal Year: 2020, Volume and Issue: 53(7), P. 1389 - 1400

Published: June 29, 2020

ConspectusNanozymes, which integrate the advantages of both nanomaterials and natural enzymes, have accumulated enormous research interest over past decades because opportunity they provide to appreciate further cultivate artificial enzymes with comparable properties. By mimicking coordination environments catalytic sites in nanozymes confined nanostructures can serve as substitutes many processes activity robust stability even harsh conditions. Since pioneering report about peroxidase-mimicking ferromagnetic nanoparticles 2007, been developed specialized for intrinsic enzyme-mimicking property. With rapid development nanoscience nanotechnology, superior advantages, such large-scale production, desired activity, stability, bridge nanozymes.Metal–organic frameworks (MOFs) their derivatives hold great promise direct surrogates conventional enzymatic reactions. According chemical nature, MOF-based be divided into three main categories: pristine MOFs, enzyme-encapsulated MOF composites, derivatives. Due versatility metallic nodes bridging linkers together feasibility postsynthetic engineering modification, MOFs are envisioned one most appropriate this purpose. Using precursors or sacrificial templates, multiple including carbon-based (e.g., heteroatom-doped carbon M–N–C moiety), metal oxide/carbon nanoparticles, metal/carbon rationally synthesized through one-step carbonization/oxidation indirect post-synthesis treatments linker-exchange node-doping). Compared existing nanozymes, open up a new avenue constructing mesoporous nanozymes. In way, properties still maintained, while greatly improved. Account, we highlight some important advances (including moieties (M = single atom), oxide/carbon, metal/carbon, obtained linker exchange doping strategies) activity. We also demonstrate that, integrating physicochemical activities MOF-derived multifunctional platforms biomedical fields antibacterial agents, biosensors, imaging, cancer therapy, environmental protection. Finally, propose future design principles possible approaches deeper understanding mechanisms, thus pointing out directions offer more opportunities enzyme-engineering industry.

Language: Английский

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The recent progress on metal–organic frameworks for phototherapy

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(8), P. 5086 - 5125

Published: Jan. 1, 2021

Some infectious or malignant diseases such as cancers are seriously threatening the health of human beings all over world. The commonly used antibiotic therapy cannot effectively treat these within a short time, and also bring about adverse effects drug resistance immune system damage during long-term systemic treatment. Phototherapy is an emerging antibiotic-free strategy to diseases. Upon light irradiation, phototherapeutic agents can generate cytotoxic reactive oxygen species (ROS) induce temperature increase, which leads death targeted cells. These two kinds killing strategies referred photodynamic (PDT) photothermal (PTT), respectively. So far, many photo-responsive have been developed. Among them, metal-organic framework (MOF) becoming one most promising materials because its structure chemical compositions be easily modulated achieve specific functions. MOFs intrinsic ability under rational design MOF construction, serve carrier therapeutic agents, owing tunable porosity. provide feasibility for various combined therapies targeting methods, improves efficiency phototherapy. In this review, we firstly investigated principles phototherapy, comprehensively summarized recent advances in PDT, PTT synergistic therapy, from construction modification. We expect that our demonstration will shed on future development field, it step closer clinical trials.

Language: Английский

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Stimuli‐Responsive Manganese Single‐Atom Nanozyme for Tumor Therapy via Integrated Cascade Reactions

Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 60(17), P. 9480 - 9488

Published: Feb. 6, 2021

Abstract The single‐atom enzyme (SAE) is a novel type of nanozyme that exhibits extraordinary catalytic activity. Here, we constructed PEGylated manganese‐based SAE (Mn/PSAE) by coordination manganese to nitrogen atoms in hollow zeolitic imidazolate frameworks. Mn/PSAE catalyzes the conversion cellular H 2 O . OH through Fenton‐like reaction; it also promotes decomposition and continuously cytotoxic − via oxidase‐like activity more pronounced weak acidic tumor environment; therefore, these cascade reactions enable sufficient generation reactive oxygen species (ROS) effectively kill cells. prominent photothermal property amorphous carbon can be utilized for therapy. Hence, significant therapeutic efficacy microenvironment stimulated multiple ROS

Language: Английский

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Nanoparticles modified by polydopamine: Working as “drug” carriers

Bioactive Materials, Journal Year: 2020, Volume and Issue: 5(3), P. 522 - 541

Published: April 18, 2020

Inspired by the mechanism of mussel adhesion, polydopamine (PDA), a versatile polymer for surface modification has been discovered. Owing to its unique properties like extraordinary adhesiveness, excellent biocompatibility, mild synthesis requirements, as well distinctive drug loading approach, strong photothermal conversion capacity and reactive oxygen species (ROS) scavenging facility, various PDA-modified nanoparticles have desired carriers. These with diverse nanostructures are exploited in multifunctions, consisting targeting, imaging, chemical treatment (CT), photodynamic therapy (PDT), (PTT), tissue regeneration ability, therefore attracted great attentions plenty biomedical applications. Herein, recent progress nanoparticle carriers cancer therapy, antibiosis, prevention inflammation, theranostics, vaccine delivery adjuvant, repair implant materials reviewed, including preparation their strategies, basic roles PDA modification, etc. The advantages overcoming existing limitations developing trends future also discussed.

Language: Английский

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A Novel Pt–TiO₂ Heterostructure with Oxygen‐Deficient Layer as Bilaterally Enhanced Sonosensitizer for Synergistic Chemo‐Sonodynamic Cancer Therapy

Advanced Functional Materials, Journal Year: 2020, Volume and Issue: 30(13)

Published: Feb. 14, 2020

Abstract Sonodynamic therapy (SDT) activated by ultrasound is attractive as a potential alternative to conventional phototriggered therapies owing the deeper penetration depth and absence of phototoxicity. Nevertheless, low quantum yield nano‐sonosensitizer tumor hypoxia remain significant challenges for SDT. Herein, novel TiO 2 ‐based reported bilaterally enhance simultaneous integration precious metal Pt nanoparticles (NPs) an oxygen‐deficient layer. Furthermore, hollow cavity serves reservoir load doxorubicin, anticancer drug chemotherapy well molecular sonosensitizer The decorated NPs act nanozymes catalyze decomposition endogenous hydrogen peroxide generation oxygen alleviate hypoxia, reduce resistance chemotherapy, provide sufficient source subsequently facilitating SDT‐induced reactive species production. high chemo‐sonodynamic synergistic efficacy systematically demonstrated both in vitro vivo. More importantly, it believed that design new finding synthesis Pt–TiO heterostructures can be popularized preparation application semiconductor‐based nanoplatforms many fields.

Language: Английский

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Au2Pt-PEG-Ce6 nanoformulation with dual nanozyme activities for synergistic chemodynamic therapy / phototherapy

Biomaterials, Journal Year: 2020, Volume and Issue: 252, P. 120093 - 120093

Published: May 10, 2020

Language: Английский

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Photodynamic therapy for hypoxic tumors: Advances and perspectives

Coordination Chemistry Reviews, Journal Year: 2021, Volume and Issue: 438, P. 213888 - 213888

Published: March 16, 2021

Language: Английский

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Tumor‐Microenvironment‐Activated Reactive Oxygen Species Amplifier for Enzymatic Cascade Cancer Starvation/Chemodynamic /Immunotherapy

Advanced Materials, Journal Year: 2021, Volume and Issue: 34(4)

Published: Oct. 26, 2021

At present, some progress has been made in the field of cancer theranostics based on nanocatalysts (NCs), but achieving precise response to specific tumor microenvironment (TME) remains a major challenge. Herein, TME-responsive upconversion nanoparticles (UCNPs)-based smart UCNPs@Cu-Cys-GOx (UCCG) nanosystem is engineered, which combines natural enzymes and nanozymes so as amplify reactive oxygen species (ROS) generation situ for starvation/chemodynamic/immunotherapy. One biggest merits this material that it can be preserved inert (off) normal tissues, only TME specifically activated (on) through series enzymatic cascades boost ROS production via strategy open source (H2 O2 self-supplying ability) reduce expenditure (glutathione (GSH) consuming ability). More importantly, enhanced oxidative stress by UCCG NCs reverses immunosuppressive TME, facilitates antitumor immune responses. Meanwhile, starvation/chemodynamic synergistic therapy triggered combined with PD-L1 antibody effectively inhibits growth primary tumors metastasis. In addition, UCNPs present luminescence enhancement, exploited visualize reinforced real time. Collectively, work provides an original method devising exploitation UCNPs-based catalytic immunotherapy.

Language: Английский

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Phenolic-enabled nanotechnology: versatile particle engineering for biomedicine

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(7), P. 4432 - 4483

Published: Jan. 1, 2021

Phenolics are ubiquitous in nature and have gained immense research attention because of their unique physiochemical properties widespread industrial use. In recent decades, accessibility, versatile reactivity, relative biocompatibility catalysed phenolic-enabled nanotechnology (PEN) particularly for biomedical applications which been a major benefactor this emergence, as largely demonstrated by polydopamine polyphenols. Therefore, it is imperative to overveiw the fundamental mechanisms synthetic strategies PEN state-of-the-art provide timely comprehensive summary. review, we will focus on principles involved summarize use toolkit particle engineering bottom-up synthesis nanohybrid materials. Specifically, discuss attractive forces between phenolics complementary structural motifs confined systems synthesize high-quality products with controllable size, shape, composition, well surface chemistry function. Additionally, phenolic's numerous biosensing, bioimaging, disease treatment be highlighted. This review aims guidelines new scientists field serve an up-to-date compilation what has achieved area, while offering expert perspectives PEN's translational research.

Language: Английский

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