Customized materials-assisted microorganisms in tumor therapeutics

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(22), P. 12576 - 12615

Published: Jan. 1, 2021

This review provides a comprehensive introduction to microorganisms-based biohybrid systems, namely MAMO, for application in tumor therapeutics.

Language: Английский

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Designed protein- and peptide-based hydrogels for biomedical sciences

Journal of Materials Chemistry B, Journal Year: 2021, Volume and Issue: 9(8), P. 1919 - 1940

Published: Jan. 1, 2021

Proteins are fundamentally the most important macromolecules for biochemical, mechanical, and structural functions in living organisms. Therefore, they provide us with diverse building blocks constructing various types of biomaterials, including an class such materials, hydrogels. Since natural peptides proteins biocompatible biodegradable, have features advantageous their use as hydrogels biomedical applications. They display constitutional mechanical similarities native extracellular matrix (ECM), can be easily bio-functionalized via genetic chemical engineering bio-recognition, specific stimulus-reactivity, controlled degradation. This review aims to give overview made up recombinant or synthetic elements polymer network. A wide variety composed protein peptide different origins compositions - β-hairpin peptides, α-helical coiled coil elastin-like silk fibroin, resilin been designed date. In this review, structures characteristics these each gelation mechanisms, physical, chemical, properties well biocompatibility resulting described. addition, discusses potential using protein- peptide-based field sciences, especially tissue engineering.

Language: Английский

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Current and Near-Future Technologies to Quantify Nanoparticle Therapeutic Loading Efficiency and Surface Coating Efficiency with Targeted Moieties

Bioengineering, Journal Year: 2025, Volume and Issue: 12(4), P. 362 - 362

Published: March 31, 2025

Active targeting nanoparticles are a new generation of drug and gene delivery systems with the potential for greatly improved therapeutics compared to conventional nanomedicine approaches. Despite their potential, translation active faces challenges in production scale-up batch consistency. Accurate quality control methods nanoparticle therapeutic payload coating characterization critical attaining desired levels repeatability, drug/gene loading efficiency, molecule effectiveness, safety profiles. Current limitations technologies, such as relying on ensemble-average analysis, pose assessing content surface modification heterogeneity, which can affect outcomes. Single-molecule analysis technologies have emerged promising alternative, offering rich information heterogeneity stochastic variations between batches. This review first evaluates identifies traditional tools that rely indirect, bulk solution quantification methods. Subsequently, newly emerging introduced targeted moiety efficiencies single-nanoparticle resolution, help guide researchers towards advancing into clinical setting.

Language: Английский

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Protein Particles Decorated with Pd Nanoparticles for the Catalytic Reduction of p-Nitrophenol to p-Aminophenol

ACS Applied Nano Materials, Journal Year: 2020, Volume and Issue: 3(10), P. 10487 - 10496

Published: Sept. 28, 2020

Nano-biomaterial hybridization is a promising strategy to generate unique and advanced material properties that are not available with nano- or biomaterials alone. In particular, the surface stabilizer (surfactant)-free synthesis of catalytic metal nanoparticles (NPs) on biological scaffolds such as protein particles (PPs) holds great potential in improving their performance because surfactants form an organic layer NP severely deactivate surface. Here, we report surfactant-free palladium (PdNPs) using PPs synthetic scaffold significantly improved Pd–protein nanocomposites (PdNP–PPs). The PdNP–PPs have many small PdNPs clean enlarged area PP Because charge property PPs, well dispersed without being aggregated reaction solutions exhibit much higher activity better durability/recyclability compared surfactant-coated reduction converting p-nitrophenol p-aminophenol.

Language: Английский

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Supramolecular Nanoparticles of Histone and Hyaluronic Acid for Co-Delivery of siRNA and Photosensitizer In Vitro

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(10), P. 5424 - 5424

Published: May 16, 2024

Small interfering RNA (siRNA) has significant potential as a treatment for cancer by targeting specific genes or molecular pathways involved in development and progression. The addition of siRNA to other therapeutic strategies, like photodynamic therapy (PDT), can enhance the anticancer effects, providing synergistic benefits. Nevertheless, effective delivery into target cells remains an obstacle therapy. Herein, supramolecular nanoparticles were fabricated via co-assembly natural histone hyaluronic acid co-delivery HMGB1-siRNA photosensitizer chlorin e6 (Ce6) MCF-7 cell. produced siRNA-Ce6 (siRNA-Ce6 NPs) have spherical morphology exhibit uniform distribution. In vitro experiments demonstrate that NPs display good biocompatibility, enhanced cellular uptake, improved cytotoxicity. These outcomes indicate constructed hold enormous promise means towards synergetic

Language: Английский

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Active Targeting of Dendritic Polyglycerols for Diagnostic Cancer Imaging

Small, Journal Year: 2019, Volume and Issue: 16(7)

Published: Dec. 26, 2019

Abstract Active tumor targeting involves the decoration of nanomaterials (NMs) with oncotropic vector biomolecules that selectively recognize certain antigens on malignant cells or in microenvironment. This strategy can facilitate intracellular uptake NM through specific interactions such as receptor‐mediated endocytosis and lead to prolonged retention tissues by preventing rapid efflux from tumor. Here, design actively targeting, renally excretible bimodal dendritic polyglycerols (dPGs) for diagnostic cancer imaging is described. Single‐domain antibodies (sdAbs) specifically binding epidermal growth factor receptor (EGFR) are employed herein warheads owing their small size high affinity corresponding antigen. The dPGs equipped EGFR‐targeting feature compared head‐to‐head nontargeting counterparts terms interaction EGFR‐overexpressing vitro well accumulation at receptor‐positive tumors vivo. Experimental results reveal a higher specificity preferential α‐EGFR dPGs, resulting introduction active capabilities backbone. These highlight potential improving properties strategic use sdAb functionalization, which ultimately prove useful development ultrasmall highly accumulation.

Language: Английский

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Protein-based biomaterials for combating viral infections: Current status and future prospects for development

Biosafety and Health, Journal Year: 2022, Volume and Issue: 4(2), P. 87 - 94

Published: March 8, 2022

The outbreak of viral infections are serious threat to human life and health. However, there remains be a lack effective treatments prophylactic measures against some infections. Additionally, numerous challenges in developing vaccines antiviral drugs (e.g., antibodies protein inhibitors), such as low immunogenicity vaccines, difficulties storing instability easy degradation drugs, drug selectivity. Protein-based biomaterials can interact with or achieve synergistic enhanced effects, making them promising tool many advantages. Silk fibroin has the potential stabilize liquid at room temperature. Elastin-like polypeptide modification improve stability yield virus-neutralizing antibodies. Drugs combination β-casein serum albumin (SA) good prospects treating immunodeficiency virus (HIV) Moreover, greatest value SA protein-based material lies its ability target liver macrophages. In future, (direct conjugation encapsulation drugs) may better treatment strategy for hepatitis HIV because it leads fewer adverse reactions. addition, self-assembling nanoparticles (SApNPs) found vaccine immunogenicity. multiple immunogens SApNPs produces different candidates, thus highlighting SApNPs. This review aimed discuss current status future development combat

Language: Английский

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A Platinum-Protein hybrid nanostructure enables both targeted cancer theragnosis and platinum clearance

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 494, P. 152957 - 152957

Published: June 12, 2024

Language: Английский

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Nonimmunogenetic Viral Capsid Carrier with Cancer Targeting Activity

Advanced Science, Journal Year: 2018, Volume and Issue: 5(8)

Published: June 27, 2018

Although protein nanoparticles (PNPs) (e.g., viral capsids) capable of delivering a broad range drug agents have shown distinctive advantages over synthetic nanomaterials, PNPs an intrinsic drawback that hampers their clinical application, is, potential immunogenicity. Here, novel method for resolving the immunogenicity problem PNPs, which is based on genetic presentation albumin-binding peptides (ABPs) surface PNP, reported. ABPs are inserted into capsid (hepatitis B virus capsid/HBVC) while preserving native self-assembly function HBVC. The effectively gather human serum albumins around HBVC and significantly reduce both inflammatory response immunoglobulin titer in live mice compared to ABP-free Furthermore, ABP-conjugated HBVCs remain within tumors longer period than conjugated tumor cell receptor-bindingpeptides, indicating also enhancing tumor-targeting performance. applied proof concept, this approach may provide general platform cancer-targeting problems enables development variety PNP-based delivery carriers with high safety efficacy.

Language: Английский

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A Review of the Current State of Nanomedicines for Targeting and Treatment of Cancers: Achievements and Future Challenges

Advanced Therapeutics, Journal Year: 2020, Volume and Issue: 4(2)

Published: Nov. 9, 2020

Abstract The design and utilization of nanomedicines offers great potential for treating various diseases including cancers. Current challenges with traditional cancer treatment strategies include but are not limited to lack specific targeting, overt systemic toxicity low efficacy. use nanomaterials show particular promise as candidates due their high surface volume ratio tuneable size, shape, chemistry, which in combination, allow improved tumor targeting enhanced therapeutic scrutinization the literature demonstrates nanosized carrier systems over approaches (at molecular level) tumors. Despite showing preclinical studies, number reaching clinical testing is still very low. This review attempts address this issue by using a weight evidence approach different combating cancer, well highlighting areas that field clearly lagging behind in, compared conventional drug discovery development. It hoped recommendations will better translation trials.

Language: Английский

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