Advances of nanoparticles as drug delivery systems for disease diagnosis and treatment

Chinese Chemical Letters, Journal Year: 2022, Volume and Issue: 34(2), P. 107518 - 107518

Published: May 14, 2022

Language: Английский

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Biomedical polymers: synthesis, properties, and applications

Science China Chemistry, Journal Year: 2022, Volume and Issue: 65(6), P. 1010 - 1075

Published: April 24, 2022

Language: Английский

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Bioengineered nanogels for cancer immunotherapy

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(12), P. 5136 - 5174

Published: Jan. 1, 2022

Recent years have witnessed increasingly rapid advances in nanocarrier-based biomedicine aimed at improving treatment paradigms for cancer. Nanogels serve as multipurpose and constructed vectors formed via intramolecular cross-linking to generate drug delivery systems, which is attributed predominantly their satisfactory biocompatibility, bio-responsiveness, high stability, low toxicity. Recently, immunotherapy has experienced unprecedented growth become the preferred strategy cancer treatment, mainly involves mobilisation of immune system an enhanced anti-tumour immunity tumour microenvironment. Despite inspiring success, immunotherapeutic strategies are limited due response rates immune-related adverse events. Like other nanomedicines, nanogels comparably by lower focal enrichment upon introduction into organism injection. Because three-dimensional cross-linked aqueous materials that exhibit similar properties natural tissues structurally stable, they can comfortably cope with shear forces serum proteins bloodstream, longer circulation life increases chance nanogel accumulation tumour, conferring deep penetration. The large specific surface area reduce or eliminate off-target effects introducing stimuli-responsive functional groups, allowing multiple physical chemical modifications purposes improve targeting cell subpopulations organs, increasing bioavailability drug, a events on therapies. slow release reaching site facilitates long-term awakening host's system, ultimately achieving therapeutic effects. As effective candidate immunotherapy, nanogel-based been widely used. In this review, we summarize recent deliver immunomodulatory small molecule drugs, antibodies, genes cytokines, target antigen presenting cells, form vaccines, enable chimeric receptor (CAR)-T therapy. Future challenges well expected feasible prospects clinical also highlighted.

Language: Английский

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Modular-designed engineered bacteria for precision tumor immunotherapy via spatiotemporal manipulation by magnetic field

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: March 23, 2023

Abstract Micro-nano biorobots based on bacteria have demonstrated great potential for tumor diagnosis and treatment. The bacterial gene expression drug release should be spatiotemporally controlled to avoid in healthy tissues undesired toxicity. Herein, we describe an alternating magnetic field-manipulated tumor-homing developed by genetically modifying engineered Escherichia coli with Fe 3 O 4 @lipid nanocomposites. After accumulating orthotopic colon tumors female mice, the paramagnetic nanoparticles enable receive convert signals into heat, thereby initiating of lysis proteins under control a heat-sensitive promoter. then lyse, releasing its anti-CD47 nanobody cargo, that is pre-expressed within bacteria. robust immunogenicity lysate cooperates activate both innate adaptive immune responses, generating antitumor effects against not only but also distal mice. magnetically constant field-controlled motion enhanced targeting increased therapeutic efficacy. Thus, behavior can manipulated vivo field, achieving tumor-specific CD47 blockage precision immunotherapy.

Language: Английский

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Progress of engineered bacteria for tumor therapy

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 185, P. 114296 - 114296

Published: April 16, 2022

Language: Английский

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Engineered Living Materials for Advanced Diseases Therapy

Advanced Materials, Journal Year: 2023, Volume and Issue: unknown

Published: July 12, 2023

Abstract Natural living materials serving as biotherapeutics exhibit great potential for treating various diseases owing to their immunoactivity, tissue targeting, and other biological activities. In this review, the recent developments in engineered materials, including mammalian cells, bacteria, viruses, fungi, microalgae, plants, active derivatives that are used summarized. Further, future perspectives challenges of such material‐based discussed provide considerations advances biomedical applications.

Language: Английский

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Biomimetic piezoelectric nanomaterial-modified oral microrobots for targeted catalytic and immunotherapy of colorectal cancer

Science Advances, Journal Year: 2024, Volume and Issue: 10(19)

Published: May 8, 2024

Lactic acid (LA) accumulation in the tumor microenvironment poses notable challenges to effective immunotherapy. Here, an intelligent treatment microrobot based on unique physiological structure and metabolic characteristics of

Language: Английский

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Advances in Salmonella Typhimurium-based drug delivery system for cancer therapy

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 185, P. 114295 - 114295

Published: April 13, 2022

Language: Английский

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Chemically engineering cells for precision medicine

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(3), P. 1068 - 1102

Published: Jan. 1, 2023

This review summarizes chemical tools for cell engineering, introduces their wide application in diagnosis and therapy, discusses the challenges opportunities precision medicine.

Language: Английский

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Nano Proteolysis Targeting Chimeras (PROTACs) with Anti‐Hook Effect for Tumor Therapy

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(37)

Published: July 24, 2023

Abstract Proteolysis targeting chimera (PROTAC) is an emerging pharmacological modality with innovated post‐translational protein degradation capabilities. However, off‐target induced unintended tissue effects and intrinsic “hook effect” hinder PROTAC biotechnology to be maturely developed. Herein, intracellular fabricated nano proteolysis chimeras (Nano‐PROTACs) a center‐spoke network for achieving efficient dose‐dependent in tumor reported. The precursors are triggered by higher GSH concentrations inside cells, which subsequently situ self‐assemble into Nano‐PROTACs through intermolecular hydrogen bond interactions. fibrous can form effective polynary complexes E3 ligases multi‐binding sites, “anti‐hook effect”. generality efficacy of validated degrading variable interest (POI) such as epidermal growth factor receptor (EGFR) androgen (AR) wide‐range manner 95 % rate long‐lasting potency up 72 h vitro. Significantly, achieve vivo 79 inhibition A549 LNCap xenograft mice models, respectively. Taking advantages self‐assembly strategy, the provide generalizable platform promote precise clinical translational application PROTAC.

Language: Английский

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