Catalase‐Like Nanozymes: Classification, Catalytic Mechanisms, and Their Applications

Small, Journal Year: 2022, Volume and Issue: 18(37)

Published: Aug. 15, 2022

The field of nanozymes has developed rapidly over the past decade. Among various oxidoreductases mimics, catalase (CAT)-like nanozyme, acting as an essential part regulation reactive oxygen species (ROS), attracted extensive research interest in recent years. However, CAT-like are not well discussed other such peroxidase (POD)-like nanozymes, etc. Compared with natural or artificial CAT enzymes, have unique properties low cost, size-dependent properties, high catalytic activity and stability, easy surface modification, etc., which make them widely used fields, especially tumor therapy disease treatment. Consequently, there is a great requirement to systematic discussion on nanozymes. In this review, some key aspects deeply summarized as: 1) Typical classified by different nanomaterials; 2) mechanisms proposed experimental theoretical studies; 3) Extensive applications regard therapy, cytoprotection sensing. Therefore, it prospected that review will contribute further design optimize their much higher efficiency than before.

Language: Английский

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Advances in metal–organic framework-based nanozymes and their applications

Coordination Chemistry Reviews, Journal Year: 2021, Volume and Issue: 449, P. 214216 - 214216

Published: Sept. 15, 2021

Language: Английский

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Persistent Regulation of Tumor Hypoxia Microenvironment via a Bioinspired Pt‐Based Oxygen Nanogenerator for Multimodal Imaging‐Guided Synergistic Phototherapy

Advanced Science, Journal Year: 2020, Volume and Issue: 7(17)

Published: July 29, 2020

Multifunctional nanoplatforms for imaging-guided synergistic antitumor treatment are highly desirable in biomedical applications. However, anticancer is largely affected by the pre-existing hypoxic tumor microenvironment (TME), which not only causes resistance of tumors to photodynamic therapy (PDT), but also promotes tumorigenesis and progression. Here, a continuous O

Language: Английский

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Multifunctional metal-organic framework (MOF)-based nanoplatforms for cancer therapy: from single to combination therapy

Theranostics, Journal Year: 2022, Volume and Issue: 13(1), P. 295 - 323

Published: Dec. 19, 2022

Cancer remains a severe threat to human health. To date, although various therapeutic methods, including radiotherapy (RT), chemotherapy, chemodynamic therapy (CDT), phototherapy, starvation therapy, and immunotherapy, have entered new stage of rapid progress in cancer theranostics, their limited effect significant side effects need be considered carefully. With the development nanotechnology, marriage nanomaterials methods provides practical possibility improve deficiencies therapy. Notably, metal-organic frameworks (MOFs) composed ions/clusters bridging ligands through coordination bonds been widely applied deal with drawbacks different such as effects, low stability, poor efficacy, owing controllable morphologies, tailorable diameters, diverse compositions, tunable porosities, high specific surface areas, facile functionalization, good biocompatibility. This review summarizes recent advanced developments achievements multifunctional MOF-based nanoplatforms for single RT, CDT, phototherapy (photodynamic photothermal therapy), combination methods. Moreover, prospects challenges used tumor are also discussed.

Language: Английский

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Applications of Metal-Organic Frameworks as Drug Delivery Systems

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(8), P. 4458 - 4458

Published: April 18, 2022

In the last decade, metal organic frameworks (MOFs) have shown great prospective as new drug delivery systems (DDSs) due to their unique properties: these materials exhibit fascinating architectures, surfaces, composition, and a rich chemistry of compounds. The DSSs allow release active pharmaceutical ingredient accomplish desired therapeutic response. Over past few decades, there has been exponential growth many classes coordination polymers, MOFs gained popularity over other identified higher biocompatibility versatile loading capabilities. This review presents assesses most recent research, findings, challenges associated with use DDSs. Among commonly used for investigated-purpose MOFs, polymers complexes based on synthetic natural are well known. Specific attention is given stimuli- multistimuli-responsive MOFs-based Of interest in COVID-19 pandemic combination therapy multimodal systems.

Language: Английский

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Mixed‐Metal MOF‐Derived Hollow Porous Nanocomposite for Trimodality Imaging Guided Reactive Oxygen Species‐Augmented Synergistic Therapy

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(37)

Published: June 26, 2021

Abstract Here an excellent trimodality imaging‐guided synergistic photothermal therapy (PTT)/photodynamic (PDT)/chemodynamic (CDT) is proposed. To this end, a mixed‐metal Cu/Zn‐metal‐organic framework (MOF) first assembled at room temperature on nano‐scale. Interestingly, heating the MOF results in Cu +/2+ ‐coexisting hollow porous structure. Subsequent treatment used to integrate Mn 2+ and MnO 2 presence of manganese(II) acetylacetonate. The composite achieves efficient loading photosensitizer, indocyanine green (ICG). Under laser irradiation, aggregated ICG imaging PTT. Once released tumor site, exhibits fluorescence PDT capacity. + /Mn ions perform Fenton‐like reaction with H O produce cytotoxic •OH for enhanced CDT. /MnO scavenge glutathione improve reactive oxygen species‐based therapy, while formed enable “turn on” magnetic resonance imaging. Significantly, produced from catalytic decomposition endogenous ICG‐mediated PDT. Moreover, photothermal‐induced local hyperthermia accelerates generation enhance This drug‐free antitumor strategy realizes high efficacy low side effects normal tissues. Thus, realize structures multi‐function integration therapeutic

Language: Английский

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Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: July 1, 2024

The applications of hydrogels have expanded significantly due to their versatile, highly tunable properties and breakthroughs in biomaterial technologies. In this review, we cover the major achievements potential therapeutic applications, focusing primarily on two areas: emerging cell-based therapies promising non-cell modalities. Within context cell therapy, discuss capacity overcome existing translational challenges faced by mainstream therapy paradigms, provide a detailed discussion advantages principal design considerations for boosting efficacy as well list specific examples different disease scenarios. We then explore drug delivery, physical intervention therapies, other areas (e.g., bioadhesives, artificial tissues, biosensors), emphasizing utility beyond mere delivery vehicles. Additionally, complement our latest progress clinical application outline future research directions, particularly terms integration with advanced biomanufacturing This review aims present comprehensive view critical insights into selection both tailored meet requirements diverse diseases situations.

Language: Английский

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Gold Nanoparticles in Cancer Theranostics

Frontiers in Bioengineering and Biotechnology, Journal Year: 2021, Volume and Issue: 9

Published: April 13, 2021

Conventional cancer treatments, such as surgical resection, radiotherapy, and chemotherapy, have achieved significant progress in therapy. Nevertheless, some limitations (such toxic side effects) are still existing for conventional therapies, which motivate efforts toward developing novel theranostic avenues. Owning many merits easy surface modification, unique optical properties, high biocompatibility, gold nanoparticles (AuNPs GNPs) been engineered to serve targeted delivery vehicles, molecular probes, sensors, so on. Their small size characteristics enable them extravasate access the tumor microenvironment (TME), is a promising solution realize highly effective treatments. Moreover, stimuli-responsive properties (respond hypoxia acidic pH) of TME GNPs’ unrivaled control transport therapeutic cargos. In this review article, we primarily introduce basic GNPs, further discuss recent theranostics, with an additional concern about studies.

Language: Английский

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A Photoresponsive Nanozyme for Synergistic Catalytic Therapy and Dual Phototherapy

Small, Journal Year: 2021, Volume and Issue: 17(10)

Published: Jan. 19, 2021

Abstract Dual phototherapy, including photodynamic therapy (PDT) and photothermal (PTT), has shown a great prospect in cancer treatment. However, its therapeutic effect is restricted by the depth of light penetration tissue tumor hypoxia environment. Herein, inspired specific response nanozymes to microenvironment (TME), simple versatile nanozyme‐mediated synergistic dual phototherapy nanoplatform (denoted as FePc/HNCSs) constructed using hollow nitrogen‐doped carbon nanospheres (HNCSs) iron phthalocyanine (FePc). FePc/HNCSs simultaneously exhibit peroxidase (POD)‐ catalase (CAT)‐like activities, which not only can convert endogenous hydrogen peroxide (H 2 O ) into highly toxic hydroxyl radicals (•OH) for catalytic therapy, but also decompose H oxygen (O enhance ‐dependent PDT. In addition, their enzyme‐like activities are significantly enhanced under irradiation. Combining with excellent effect, realize high inhibition rate 96.3%. This strategy opens new horizon exploring more powerful treatment nanoplatform.

Language: Английский

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Photocatalytic systems: reactions, mechanism, and applications

RSC Advances, Journal Year: 2024, Volume and Issue: 14(29), P. 20609 - 20645

Published: Jan. 1, 2024

The photocatalytic field revolves around the utilization of photon energy to initiate various chemical reactions using non-adsorbing substrates, through processes such as single electron transfer, or atom transfer.

Language: Английский

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