A Poly-γ-Glutamic Acid/ε-Polylysine Hydrogel: Synthesis, Characterization, and Its Role in Accelerated Wound Healing DOI Creative Commons
Jiaqi Li,

Yuanli Huang,

Yalu Wang

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(4), P. 226 - 226

Published: March 22, 2025

Wound healing is a complex biological process involving inflammation, proliferation, and remodeling phases. Effective essential for maintaining skin integrity, driving the need advanced materials like hydrogels, known their high water retention tunable mechanical properties. In this study, we synthesized biocompatible composite hydrogel composed of γ-polyglutamic acid (γ-PGA) ε-polylysine (ε-PL) through Schiff base reaction, forming stable crosslinked network. Its physicochemical properties, including rheological behavior swelling capacity, were systematically evaluated. Biocompatibility was assessed via in vitro hemolysis cytotoxicity assays, vivo testing performed using full-thickness defect model Sprague Dawley (SD) rats to evaluate wound-healing efficacy. The PGA-PL demonstrated excellent with maximum ratio 65.6%, biocompatibility as evidenced by low rates (<5%) cell viability (>80%). It promoted wound inhibiting inflammatory response, reducing levels cytokine IL-6, enhancing angiogenesis, accelerating collagen deposition. showed complete biodegradation within 21 days without inducing significant response significantly accelerated healing, achieving an 86% rate 7 compared 67% control group. exhibits strength biocompatibility, its effective capabilities lay groundwork future development optimization various tissue engineering applications.

Language: Английский

STIMULI-RESPONSIVE SUPRAMOLECULAR HYDROGELS FOR PACLITAXEL DELIVERY: PROGRESS AND PROSPECTS DOI Creative Commons

Mohammad Qutub,

Amol Tatode, Jayshree Taksande

et al.

Aspects of Molecular Medicine, Journal Year: 2025, Volume and Issue: 5, P. 100062 - 100062

Published: Jan. 5, 2025

Citations

9
Environmental and Wastewater Treatment Applications of Stimulus-Responsive Hydrogels DOI Creative Commons
Anita Ioana Vișan, Irina Neguț

Gels, Journal Year: 2025, Volume and Issue: 11(1), P. 72 - 72

Published: Jan. 16, 2025

Stimulus-responsive hydrogels have emerged as versatile materials for environmental and wastewater treatment applications due to their ability adapt changing conditions. This review highlights recent advances in the design, synthesis, functionalization of such hydrogels, focusing on applications. Various synthesis techniques, including radical polymerization, grafting, copolymerization, enable development with tailored properties enhanced adsorption capacity, selectivity, reusability. The incorporation nanoparticles bio-based polymers further improves structural integrity pollutant removal efficiency. Key mechanisms adsorption, ion exchange, photodegradation are discussed, emphasizing roles removing heavy metals, dyes, organic pollutants from wastewater. Additionally, this presents potential oil-water separation, pathogen control, future sustainability through integration into circular economy frameworks. adaptability, cost-effectiveness, eco-friendliness these make them promising candidates large-scale remediation.

Language: Английский

Citations

4
Hydrogels for Peripheral Nerve Repair: Emerging Materials and Therapeutic Applications DOI Creative Commons

Oana Taisescu,

Venera Cristina Dinescu, Alexandra Daniela Rotaru-Zavaleanu

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(2), P. 126 - 126

Published: Feb. 9, 2025

Peripheral nerve injuries pose a significant clinical challenge due to the complex biological processes involved in repair and their limited regenerative capacity. Despite advances surgical techniques, conventional treatments, such as autografts, are faced with limitations like donor site morbidity inconsistent functional outcomes. As such, there is growing interest new, novel, innovative strategies enhance regeneration. Tissue engineering/regenerative medicine its use of biomaterials an emerging example strategy. Within realm tissue engineering, functionalized hydrogels have gained considerable attention ability mimic extracellular matrix, support cell growth differentiation, even deliver bioactive molecules that can promote repair. These be engineered incorporate factors, peptides, stem cells, creating conducive microenvironment for cellular axonal Recent advancements materials well biology led development sophisticated hydrogel systems, not only provide structural support, but also actively modulate inflammation, recruitment, stimulate neurogenesis. This review explores potential peripheral repair, highlighting composition, biofunctionalization, mechanisms action. A comprehensive analysis preclinical studies provides insights into efficacy these promoting growth, neuronal survival, regeneration, and, ultimately, recovery. Thus, this aims illuminate promise transformative tool field bridging gap between complexity feasibility.

Language: Английский

Citations

4
The Utilization of Biopolymer Hydrogels to Encapsulate and Protect Probiotics in Foods DOI
Great Iruoghene Edo, Alice Njolke Mafe, Patrick Othuke Akpoghelie

et al.

Process Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

4
Functionalized biomimetic nanoparticles loaded with salvianolic acid B for synergistic targeted triple-negative breast cancer treatment DOI Creative Commons
Nuo Cheng, Qianqian Zhou,

Zongfang Jia

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 30, P. 101441 - 101441

Published: Jan. 1, 2025

The therapeutic effect of immune checkpoint inhibitors (ICIs) in triple-negative breast cancer (TNBC) is unsatisfactory. "cold" microenvironment caused by tumor-associated fibroblasts (TAFs) has an adverse on the antitumor response. Therefore, this study, mixed cell membrane-coated porous magnetic nanoparticles (PMNPs) were constructed to deliver salvianolic acid B (SAB) induce response, facilitating transition from a "hot" tumor and ultimately enhancing efficacy inhibitors. PMNP-SAB, which based coating red blood membrane TAF (named PMNP-SAB@RTM), can simultaneously achieve dual effects "immune escape" "homologous targeting". Under influence external field (MF), SAB be targeted concentrated at site. released tumors effectively inhibit production extracellular matrix (ECM) TAFs, promote T-cell infiltration, responses. Ultimately, combination PMNP-SAB@RTM BMS-1 (PD-1/PD-L1 inhibitor 1) inhibited growth. Finally, study presents precise effective new strategy for TNBC immunotherapy basis differentiation microenvironments.

Language: Английский

Citations

3
Cutting-Edge Hydrogel Technologies in Tissue Engineering and Biosensing: An Updated Review DOI Open Access
Nargish Parvin, Vineet Kumar, Sang Woo Joo

et al.

Materials, Journal Year: 2024, Volume and Issue: 17(19), P. 4792 - 4792

Published: Sept. 29, 2024

Hydrogels, known for their unique ability to retain large amounts of water, have emerged as pivotal materials in both tissue engineering and biosensing applications. This review provides an updated comprehensive examination cutting-edge hydrogel technologies multifaceted roles these fields. Initially, the chemical composition intrinsic properties natural synthetic hydrogels are discussed, highlighting biocompatibility biodegradability. The manuscript then probes into innovative scaffold designs fabrication techniques such 3D printing, electrospinning, self-assembly methods, emphasizing applications regenerating bone, cartilage, skin, neural tissues. In realm biosensing, hydrogels’ responsive nature is explored through integration optical, electrochemical, piezoelectric sensors. These sensors instrumental medical diagnostics glucose monitoring, pathogen detection, biomarker identification, well environmental industrial like pollution food quality monitoring. Furthermore, explores cross-disciplinary innovations, including use wearable devices, hybrid systems, potential personalized medicine. By addressing current challenges future directions, this aims underscore transformative impact advancing healthcare practices, thereby providing a vital resource researchers practitioners field.

Language: Английский

Citations

10
Comprehensive Exploration on Chemical Functionalization and Crosslinked Injectable Hyaluronic Acid Hydrogels for Tissue Engineering Applications DOI Creative Commons
A. S. Yadav,

Datta S. Waghmare,

Anjali Ahir

et al.

Regenerative Engineering and Translational Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Language: Английский

Citations

2
A lubcan cross-linked polyethylene glycol dimethyl ether hydrogel for hyaluronic acid replacement as soft tissue engineering fillers DOI
Silu Chen, Chengtao Hu,

Weiling Lu

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 298, P. 140061 - 140061

Published: Jan. 18, 2025

Language: Английский

Citations

2
Bioengineering strategies targeting angiogenesis: Innovative solutions for osteonecrosis of the femoral head DOI Creative Commons
Weihong Zhu, Zhenmu Xu,

Ding Zhou

et al.

Journal of Tissue Engineering, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 1, 2025

Osteonecrosis of the femoral head (ONFH) is a prevalent orthopedic disorder characterized primarily by compromised blood supply. This vascular deficit results in cell apoptosis, trabecular bone loss, and structural collapse at late stage, significantly impairing joint function. While MRI highly effective tool for diagnosing ONFH its early stages, challenges remain due to limited availability high cost MRI, as well absence routine screening asymptomatic patients. . In addition, current therapeutic strategies predominantly only relieve symptoms while disease-modifying drugs are still under investigation/development. Considering that supply plays key role pathology ONFH, angiogenic therapies have been put forward promising treatment options. Emerging bioengineering interventions targeting angiogenesis hold potential treatment. this review, we introduce advances research into summarize novel angiogenesis. review sheds light upon new directions future ONFH.

Language: Английский

Citations

2
Advancements in nanocomposite hydrogels: a comprehensive review of biomedical applications DOI Creative Commons

Gargee Baishya,

Bandita Parasar,

Manisha Limboo

et al.

Discover Materials, Journal Year: 2024, Volume and Issue: 4(1)

Published: Aug. 28, 2024

Nanocomposite hydrogels (NHs) have emerged as a groundbreaking tool in biomedical applications, offering remarkable versatility and efficacy. Integrating wide range of nanoparticles, including carbon-based, polymeric, ceramic, metallic nanomaterials, within hydrogel networks results nanocomposites with superior properties tailored functionalities. Recent research has highlighted their potential to address key challenges drug delivery, cancer therapy, tissue regeneration, biosensing, wound healing, outstanding biocompatibility bioavailability. Nanohydrogels demonstrate significant promise delivery systems biological sensors, providing sustained therapeutic activity at targeted sites. This reduces the frequency administration minimizes harmful side effects. In healthcare sector, they applications ranging from therapy aesthetic corrections are leading topic regeneration research. comprehensive review Biomedical Applications investigates latest advancements NHs, focusing on classification, unique properties, diverse applications. By identifying future prospects existing gaps, this aims highlight diagnostic nanocomposite technology, covering way for further advancement field.

Language: Английский

Citations

9