Perspectives for the Use of Fucoidans in Clinical Oncology

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(19), P. 11821 - 11821

Published: Oct. 5, 2022

Fucoidans are natural sulfated polysaccharides that have a wide range of biological functions and regarded as promising antitumor agents. The activity various fucoidans their derivatives has been demonstrated in vitro on tumor cells different histogenesis experiments mice with grafted tumors. However, these experimental models showed low levels clinical trials did not prove this class compounds could serve drugs. Nevertheless, the anti-inflammatory, antiangiogenic, immunostimulating, anticoagulant properties fucoidans, well ability to stimulate hematopoiesis during cytostatic-based therapy, suggest effective fucoidan-based drugs be designed for supportive care symptomatic therapy cancer patients. use patients after chemotherapy radiation might promote rapid improvement hematopoiesis, while immunomodulatory, effects potential improve quality life advanced cancer.

Language: Английский

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Constructing biomimetic liver models through biomaterials and vasculature engineering

Regenerative Biomaterials, Journal Year: 2022, Volume and Issue: 9

Published: Jan. 1, 2022

Abstract The occurrence of various liver diseases can lead to organ failure the liver, which is one leading causes mortality worldwide. Liver tissue engineering see potential for replacing transplantation and drug toxicity studies facing donor shortages. basic elements in are cells biomaterials. Both mature hepatocytes differentiated stem be used as main source construct spheroids organoids, achieving improved cell function. To mimic extracellular matrix (ECM) environment, biomaterials need biocompatible bioactive, also help support proliferation differentiation allow ECM deposition vascularized structures formation. In addition, advanced manufacturing approaches required microenvironment, it has been proved that structured three-dimensional culture system improve activity characterization specific proteins. summary, we review engineering, including natural hydrogels synthetic polymers, processing techniques building microenvironments, bioassembly, bioprinting microfluidic methods. We then summarize application fields transplant regeneration, disease models cytotoxicity analysis. end, put challenges prospects engineering.

Language: Английский

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Reciprocal interaction between vascular niche and sweat gland promotes sweat gland regeneration

Bioactive Materials, Journal Year: 2022, Volume and Issue: 21, P. 340 - 357

Published: Sept. 14, 2022

The incorporation of vasculature is known to be effective in tissue or organ functional regeneration. However, a vague understanding the interaction between epidermal appendages and their vascular niches foremost obstacle obtaining sweat gland (SG)-specific units. Here, we map precise anatomical connections report that interplay SG cells (SGCs) surrounding niche key for glandular development homeostasis maintenance. To replicate this vitro, used three-dimensional (3D) bioprinting generate reproducible SGC spheroids from differentiated adipose-derived mesenchymal stem (ADSCs). With dermal microvascular endothelial (DMECs), sacrificial templates made poly (ε-caprolactone) (PCL) were fabricated pattern niche. This model promoted physiologically relevant vascularized morphogenesis vitro vivo. We identified reciprocal regulatory mechanism promoting SGs regeneration via contact-independent cell communication direct cell-cell interactions vasculature. envision successful use our approach near future.

Language: Английский

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Recent advances in biofabrication strategies based on bioprinting for vascularized tissue repair and regeneration

Materials & Design, Journal Year: 2023, Volume and Issue: 229, P. 111885 - 111885

Published: March 31, 2023

Vascularization plays a crucial role in transporting and exchanging nutrients oxygen between implanted grafts with the host tissue. In biofabrication of grafts, remodeling vascular networks can accelerate vascularized tissue repair regeneration. Given heterogeneity tissues, traditional scaffold manufacturing techniques cannot effectively achieve various scales vitro vivo biomimetic. recent years, 3D bioprinting technologies have been widely used fabricating for regeneration due to their shape customizability, simple procedure, reproducibility, precise multi-dimensional control. With rapid development technologies, bioprinting-based strategies gradually applied construction tissues. Based on this background, our study aimed review advances, challenges, future perspectives based The techniques, bioinks, seed cells, growth factors were also enrolled review. addition, history, vessel formation mechanism, histology discussed.

Language: Английский

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Multidimensional controllable fabrication of tumor spheroids based on a microfluidic device

Lab on a Chip, Journal Year: 2023, Volume and Issue: 23(11), P. 2654 - 2663

Published: Jan. 1, 2023

A multidimensional controllable tumor spheroid fabrication method based on droplet microfluidics and cell membrane engineering technology.

Language: Английский

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