bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: June 16, 2023
Abstract
Fucoidans
are
sulfated
polysaccharides
capable
of
exerting
biological
activities
such
as
antitumor
and
immunomodulatory
effects.
Previous
studies
demonstrated
the
activity
non-cytotoxic
fucoidan
from
seaweed
Dictyota
caribaea
(Dc-SP)
in
vivo
.
Macrophages
(Mφ)
innate
immune
cells
promoting
or
inhibiting
tumor
growth
depending
on
stimulus.
This
study
aimed
to
evaluate
immunostimulant
Dc-SP
murine
Mφ
(RAW264.7)
vitro
was
assessed
for
its
ability
modify
cell
viability
stimulate
production
markers
RAW264.7
cells.
induced
an
increase
(p<0.05)
NO
cytokines
TNF-α,
IL-1β,
IL-10.
The
exposure
also
increased
expression
M1
macrophage
iNOS,
CD86,
MHC
II.
antiproliferative
stimulated
with
DC-SP
melanoma
(B16-F10)
did
not
exhibit
direct
cytotoxicity
B16-F10,
however,
conditioned
medium
(CM)
previously
(CM-Dc-SP)
showed
B16-F10
incubated
CM-Dc-SP
a
cytostatic
profile,
alter
membrane
integrity,
suffered
morphological
changes
shrinkage
high
granularity.
In
conclusion,
phenotype.
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(5), P. 636 - 636
Published: May 15, 2024
Astragalus
polysaccharide
(APS)
derived
from
A.
membranaceus
plays
a
crucial
role
in
traditional
Chinese
medicine.
These
polysaccharides
have
shown
antitumor
effects
and
are
considered
safe.
Thus,
they
become
increasingly
important
cancer
immunotherapy.
APS
can
limit
the
spread
of
by
influencing
immune
cells,
promoting
cell
death,
triggering
autophagy,
impacting
tumor
microenvironment.
When
used
combination
with
other
therapies,
enhance
treatment
outcomes
reduce
toxicity
side
effects.
combined
checkpoint
inhibitors,
relay
cellular
immunotherapy,
vaccines
broadened
application
immunotherapy
enhanced
effectiveness.
By
summarizing
research
on
over
past
two
decades,
this
review
elaborates
anticancer
mechanism
its
use
clinical
trials.
Considering
multiple
roles
APS,
emphasizes
importance
using
as
an
adjunct
to
compares
APS.
This
discussion
provides
insights
into
specific
action
reveals
molecular
targets
for
developing
effective
strategies,
highlights
wide
therapy
future.
Marine Drugs,
Journal Year:
2023,
Volume and Issue:
21(2), P. 128 - 128
Published: Feb. 15, 2023
Fucoidans,
discovered
in
1913,
are
fucose-rich
sulfated
polysaccharides
extracted
mainly
from
brown
seaweed.
These
versatile
and
nontoxic
marine-origin
heteropolysaccharides
have
a
wide
range
of
favorable
biological
activities,
including
antitumor,
immunomodulatory,
antiviral,
antithrombotic,
anticoagulant,
antioxidant,
lipid-lowering
activities.
In
the
early
1980s,
fucoidans
were
first
recognized
for
their
role
supporting
immune
response
later,
1990s,
effects
on
potentiation
began
to
emerge.
recent
years,
understanding
immunomodulatory
fucoidan
has
expanded
significantly.
The
ability
fucoidan(s)
activate
CTL-mediated
cytotoxicity
against
cancer
cells,
strong
antitumor
property,
robust
safety
profile
make
desirable
effective
immunotherapy.
This
review
focusses
current
progress
immunopotentiation
activity
various
fucoidans,
emphasizing
relevance
Here,
we
will
discuss
action
different
cells
how
can
be
used
as
adjuvants
conjunction
with
immunotherapeutic
products
improve
treatment
clinical
outcome.
Some
key
rationales
possible
combination
immunotherapy
discussed.
An
update
is
provided
human
studies
available
registered
trials
using
while
highlighting
future
prospects
challenges.
Journal of Functional Foods,
Journal Year:
2023,
Volume and Issue:
103, P. 105486 - 105486
Published: March 9, 2023
Bioactivities
of
fucoidan,
a
class
marine
algal
polysaccharides,
vary
depending
on
the
original
species.
The
aim
this
study
was
to
explore
in
vivo
immunomodulatory
activity
fucoidan
from
Undaria
pinnatifida,
brown
alga
with
long
history
medicinal
and
food
uses
East
Asia,
sarcoma
180
(S180)
subcutaneous
xenograft-bearing
mice.
Results
showed
that
oral
administration
significantly
enhanced
phagocytotic
function
mononuclear
phagocytic
system,
increased
serum
levels
Th1
cytokines
interleukin-2,
interferon-γ
tumor
necrosis
factor-α,
promoted
spleen
T
lymphocyte
responses,
infiltration
CD11c
+
dendritic
cells
(DCs)
into
transplanted
tissues,
upregulated
surface
expression
MHC
II
costimulatory
molecule
CD86
bone
marrow-derived
CD11c+
DCs
S180-bearing
Overall,
pinnatifida
represents
an
antitumor
adjuvant
stimulating
both
innate
adaptive
immune
responses
for
patients
advanced
soft
tissue
sarcomas.
European Pharmaceutical Journal,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 20, 2025
Abstract
The
aim
of
the
study
was
to
investigate
effects
chondroitin
sulfate
(CS)
and
fucoidan
(F),
as
well
their
combination
(CS
+
F)
on
growth
viability
spheroids
derived
from
non-tumor
cell
line
NIH3T3
tumor
Hepa1c1c7
using
a
three-dimensional
(3D)
culture
model.
Spheroids
were
formed
liquid
overlay
method
treated
with
different
concentrations
substances.
Flow
cytometry
used
quantitatively
assess
representation
live,
apoptotic,
necrotic,
dead
cells
in
after
treatment.
treatment
CS
nontoxic
cells.
By
light
microscopy,
we
observed
significant
proliferative
effect
case
(F
CS).
On
contrary,
line,
our
compounds,
especially
fucoidan,
showed
antiproliferative
effects,
which
confirms
synergistic
effect.
According
flow
spheroids,
had
most
proportion
viable
cells,
confirmed
its
(66.43
±
4.43%).
In
revealed
highest
number
(19.84
5.80%).
Based
results,
can
conclude
that
cultures.
3D
cultures
provide
more
physiologically
relevant
platform
for
drug
testing,
highlighting
importance
understanding
cell–extracellular
matrix
interactions
cancer
research.
Journal of Marine Science and Engineering,
Journal Year:
2025,
Volume and Issue:
13(2), P. 318 - 318
Published: Feb. 9, 2025
Four
types
of
algae—Porphyra
umbilicalis,
Undaria
pinnatifida,
Cystoseira
barbata,
and
Chlorella
sp.—were
used
to
obtain
crude
bioproducts
enriched
in
polysaccharides
(four
bioproducts)
create
formulations
with
gold
cations
bioproducts).
The
obtained
through
aqueous
extraction
from
barbata
exhibited
significant
antioxidant
activities
a
total
polyphenol
content
(714.17
±
1.26)
mg
GAE/L.
In
the
derived
extract
Porphyra
umbilicalis
combined
ions,
nanoparticles
sizes
less
than
34
nm
were
formed.
vitro
tests
performed
on
Caco-2
tumour
cell
line
each
eight
bioproducts,
after
24
h
exposure,
showed
that
containing
sp.
cytotoxicity
against
line.
case
HepG2
line,
indicated
only
cytotoxic
effects.
These
results
indicate
protective
effect
algal
tumourigenesis
processes
may
occur
human
digestive
system.
Regarding
gold,
no
was
observed.
However,
two
size
nm,
they
represent
potential
raw
materials
for
electrochemical
sensors.
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
172, P. 116230 - 116230
Published: Feb. 12, 2024
Ferroptosis,
a
distinct
form
of
cell
death,
is
characterized
by
the
iron-mediated
oxidation
lipids
and
finely
controlled
multiple
cellular
metabolic
pathways.
These
pathways
encompass
redox
balance,
iron
regulation,
mitochondrial
function,
as
well
amino
acid,
lipid,
sugar
metabolism.
Additionally,
various
disease-related
signaling
also
play
role
in
regulation
ferroptosis.
In
recent
years,
with
introduction
concept
ferroptosis
deepening
research
on
its
mechanism,
closely
related
to
biological
conditions
eye
diseases,
including
organ
development,
aging,
immunity,
cancer.
This
article
reviews
development
ferroptosis,
mechanism
latest
progress
ophthalmic
diseases
ocular
within
framework
metabolism,
active
oxygen
biology,
biology.
Key
regulators
mechanisms
introduce
important
concepts
major
open
questions
field
natural
compounds.
It
hoped
that
future
research,
further
breakthroughs
will
be
made
use
promote
treatment
diseases.
At
same
time,
compounds
may
direction
new
drug
for
potential
future.
Open
up
way
clinical
ophthalmologists
prevent
