ACS Applied Materials & Interfaces,
Journal Year:
2022,
Volume and Issue:
14(47), P. 52643 - 52658
Published: Nov. 16, 2022
The
high
level
of
reactive
oxygen
species
(ROS)
and
bacterial
infection
impede
wound
healing
the
diabetic
wound.
Here,
benefiting
from
antioxidation
effects
tannic
acid
(TA)
ROS-responsive
phenylborate
ester
(PBAE),
a
series
anti-inflammatory
TA-conjugated
nanoparticle
hydrogels
(PPBA-TA-PVA)
can
be
obtained
by
conveniently
mixing
TA,
phenylboric
modified
polyphosphazene
(PPBA),
poly(vinyl
alcohol)
(PVA).
PPBA-TA-PVA
could
effectively
inhibit
growth
Escherichia
coli
(antibacterial
rate
=
93.1
±
1.1%)
within
4
h
scavenge
both
2,2-diphenyl-1-picrylhydrazyl
(DPPH)
radicals
•OH
in
vitro.
Besides,
cell
migration
HDFa
cells
treated
with
(84.2
4.6%)
was
twice
normal
(43.8
8.1%)
after
24
cocultivation.
clinical
relevance
demonstrated
further
assessing
full-thickness
excisional
wounds
streptozotocin
(STZ)-induced
rat
model.
act
as
effective
ROS-scavenging
agents
to
alleviate
inflammation
accelerate
closure
decreasing
proinflammatory
cytokines
(IL-6,
IL-1β)
increasing
gene
expression
TGF-β1,
COL-1,
COL-3,
which
resulted
faster
re-epithelialization
increased
formation
granulation
tissue.
Materials Today Bio,
Journal Year:
2023,
Volume and Issue:
20, P. 100649 - 100649
Published: April 30, 2023
Due
to
local
overactive
inflammatory
response
and
impaired
angiogenesis,
current
treatments
for
diabetic
wounds
remain
unsatisfactory.
M2
macrophage-derived
exosomes
(MEs)
have
shown
considerable
potential
in
biomedical
applications,
especially
since
they
anti-inflammatory
properties
that
modulate
macrophage
phenotypes.
However,
exosome-based
strategies
still
limitations,
such
as
short
half-lives
instability.
Herein,
we
develop
a
double-layer
microneedle-based
wound
dressing
system
(MEs@PMN)
by
encapsulating
MEs
the
needle
tips
polydopamine
(PDA)
nanoparticles
backing
layer
simultaneously
suppress
inflammation
improve
angiogenesis
at
site.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(17), P. 17199 - 17216
Published: Aug. 25, 2023
The
clinical
applications
of
currently
used
photosensitizers
are
limited
by
high
costs,
inconvenient
preparation,
suboptimal
biodegradability,
and
a
lack
biological
activity.
Humic
acids
(HAs)
show
photothermal
activity
can
be
as
photosensitizer
for
therapy.
In
the
presence
various
functional
groups,
HAs
endowed
with
anti-inflammatory
antioxidant
activities.
solubility
is
dependent
on
pH
value,
which
soluble
in
neutral
to
alkaline
conditions
undergoes
conformational
change
coiled
compact
structure
acidic
conditions.
Additionally,
Cu2+
an
emerging
therapeutic
agent
cutaneous
wounds
chelated
form
complexes.
this
study,
we
explore
ability
modulate
inflammatory
response,
particularly
macrophage
polarization,
potential
underlying
mechanism.
We
fabricate
near-infrared
(NIR)/pH
dual-responsive
Cu-HAs
nanoparticle
(NP)-based
poly(vinyl
alcohol)
(PVA)
hydrogel
film
loaded
SEW2871
(SEW),
recruitment
agent,
treat
bacteria-infected
wounds.
results
that
could
promote
M2
polarization
dose-dependent
manner.
NPs
successfully
eradicated
bacterial
infection
through
NIR-induced
local
hyperthermia.
This
PVA@Cu-HAs
NPs@SEW
improves
tissue
regeneration
promoting
alleviating
oxidative
stress,
enhancing
angiogenesis,
facilitating
collagen
deposition.
These
findings
highlight
treatment
bacterially
infected
wound
healing.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(25)
Published: March 12, 2024
Abstract
Given
the
challenge
of
multidrug
resistance
in
antibiotics,
non‐antibiotic–dependent
antibacterial
strategies
show
promise
for
anti‐infective
therapy.
V
2
C
MXene‐based
nanomaterials
have
demonstrated
strong
biocompatibility
and
photothermal
conversion
efficiency
(PCE)
therapy
(PTT).
However,
limitation
MXene's
laser
irradiation
to
near‐infrared
region
I
(NIR‐I)
restricts
tissue
penetration,
making
it
difficult
achieve
complete
bacterial
eradication
with
single‐effect
therapeutic
strategies.
To
address
this,
Pt
nanoparticles
(Pt
NPs)
are
attached
C,
forming
artificial
nanoplatforms
(Pt@V
C).
Pt@V
exhibits
enhanced
PCE
(59.6%)
a
longer
(NIR‐II)
due
surface
plasmon
resonance
effect
NPs
C.
Notably,
displays
dual
enzyme‐like
activity
chemodynamic
(CDT)
NIR‐II
activity.
The
biocatalytic
mechanism
is
elucidated
using
density
functional
theory.
In
an
vivo
animal
model,
effectively
eliminates
methicillin‐resistant
Staphylococcus
aureus
from
deep‐seated
tissues
subcutaneous
abscesses
keratitis
environments,
accelerating
abscess
resolution
promoting
wound
cornea
healing
through
synergistic
effects
PTT/CDT.
Transcriptomic
analysis
reveals
that
targets
inflammatory
pathways,
providing
insight
into
its
mechanism.
This
study
presents
promising
approach
involving
hyperthermia‐amplified
biocatalysis
MXene
nanocomposites.
ACS Applied Nano Materials,
Journal Year:
2024,
Volume and Issue:
7(3), P. 2529 - 2545
Published: Jan. 18, 2024
Antibiotic
abuse
has
become
a
rising
public
health
concern
in
recent
years,
leading
to
dangerous
bacteria
developing
antibiotic
resistance
most
medicines
currently
use.
Traditional
antimicrobial
medications
have
been
helpful
the
early
stages
of
treating
numerous
forms
serious
bacterial
infectious
diseases;
however,
despite
significant
therapeutic
benefit,
there
are
number
issues
with
follow-up
treatment.
Metal-based
nanomaterials,
which
properties
including
difficulty
establishing
drug
and
advantages
reduced
cytotoxicity,
considered
promising
substances.
This
review
discusses
important
types
metal-based
nanoparticles
(MNPs),
such
as
copper,
titanium,
zinc
oxide,
etc.,
focus
on
applications
gold-
silver-based
nanoparticles.
Furthermore,
advanced
research
progress
MNPs
agents
stimuli-responsive
metal
nanoparticle
strategies
working
under
photothermal,
magnetic,
pH
stimulation
also
summarized
this
article.
In
general,
advancement
technology,
materials
based
will
offer
excellent
prospects
for
improving
applications.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(11)
Published: Jan. 16, 2024
Abstract
Achieving
photothermal
therapy
(PTT)
at
ultralow
laser
power
density
is
crucial
for
minimizing
photo‐damage
and
allowing
higher
maximum
permissible
skin
exposure.
However,
this
requires
agents
to
possess
not
just
superior
conversion
efficiency
(PCE),
but
also
exceptional
near‐infrared
(NIR)
absorptivity.
J
‐aggregates,
exhibit
a
significant
redshift
narrower
absorption
peak
with
extinction
coefficient.
Nevertheless,
achieving
predictable
‐aggregates
through
molecular
design
remains
challenge.
In
study,
we
successfully
induced
desirable
J‐
aggregation
(λ
abs
max
:
968
nm,
ϵ:
2.96×10
5
M
−1
cm
,
λ
em
972
Φ
FL
6.2
%)
by
tuning
electrostatic
interactions
between
π‐conjugated
planes
manipulating
surface
potential
of
aromatic
ring‐fused
aza‐BODIPY
dyes.
Notably,
controlling
the
preparation
method
encapsulating
dyes
into
F‐127
polymer,
were
able
selectively
generate
H
‐/
respectively.
Furthermore,
exhibited
two
controllable
morphologies:
nanospheres
nanowires.
Importantly,
shortwave‐infrared
‐aggregated
nanoparticles
impressive
PCE
72.9
%
effectively
destroyed
cancer
cells
mice‐tumors
an
0.27
W
−2
(915
nm).
This
phototherapeutic
nano‐platform,
which
generates
behavior,
can
controllably
form
/
H‐
aggregates
selectable
aggregate
morphology,
valuable
paradigm
developing
tumor‐treatment
density.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 965 - 992
Published: Jan. 1, 2024
Abstract:
Diabetic
wounds
pose
a
significant
challenge
to
public
health,
primarily
due
insufficient
blood
vessel
supply,
bacterial
infection,
excessive
oxidative
stress,
and
impaired
antioxidant
defenses.
The
aforementioned
condition
not
only
places
physical
burden
on
patients'
prognosis,
but
also
amplifies
the
economic
strain
medical
system
in
treating
diabetic
wounds.
Currently,
effectiveness
of
available
treatments
for
is
limited.
However,
there
hope
potential
metal
nanoparticles
(MNPs)
address
these
issues.
MNPs
exhibit
excellent
anti-inflammatory,
antioxidant,
antibacterial
pro-angiogenic
properties,
making
them
promising
solution
In
addition,
stimulate
expression
proteins
that
promote
wound
healing
serve
as
drug
delivery
systems
small-molecule
drugs.
By
combining
with
other
biomaterials
such
hydrogels
chitosan,
novel
dressings
can
be
developed
revolutionize
treatment
present
article
provides
comprehensive
overview
research
progress
utilization
Building
upon
this
foundation,
we
summarize
underlying
mechanisms
involved
discuss
application
delivery.
Furthermore,
provide
an
extensive
analysis
discussion
clinical
implementation
dressings,
while
highlighting
future
prospects
utilizing
management.
conclusion,
represent
strategy
healing.
Future
directions
include
biological
nanomaterials
synthesize
new
or
physicochemical
properties
Synthetic
contain
play
role
all
stages
healing,
stable
physiological
environment
wound-healing
process.
Keywords:
nanoparticles,
wound,
delivery,
activity
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(3), P. 300 - 300
Published: Feb. 21, 2024
Wounds,
which
are
becoming
more
common
as
a
result
of
traumas,
surgery,
burns,
and
chronic
illnesses
like
diabetes,
remain
critical
medical
problem.
Infectious
bacteria
impact
the
healing
process,
particularly
if
its
biofilm
(biological
films)
leads
to
prolonged
effect.
Nanomaterials
have
emerged
promising
candidates
in
field
wound
due
their
unique
properties
versatile
applications.
New
insights
into
interactions
between
nanomaterials
microenvironments
shed
light
on
mechanisms
underlying
therapeutic
effects.
However,
significantly
minimal
amount
research
has
been
carried
out
see
these
promote
process.
In
this
review,
we
provided
an
outline
various
types
that
studied
for
wounds
infection
prevention.
Overall,
utilization
holds
great
promise
continues
evolve,
providing
new
opportunities
development
effective
efficient
care
therapies.
