ACS Biomaterials Science & Engineering,
Journal Year:
2024,
Volume and Issue:
10(5), P. 2703 - 2724
Published: April 22, 2024
The
scientific
world
is
increasingly
focusing
on
rare
earth
metal
oxide
nanomaterials
due
to
their
consequential
biological
prospects,
navigated
by
breakthroughs
in
biomedical
applications.
Terbium
belongs
elements
(lanthanide
series)
and
possesses
remarkably
strong
luminescence
at
lower
energy
emission
signal
transduction
properties,
ushering
wide
applications
for
diagnostic
measurements
(i.e.,
bioimaging,
biosensors,
fluorescence
imaging,
etc.)
the
sectors.
In
addition,
theranostic
of
terbium-based
nanoparticles
further
permit
targeted
delivery
drugs
specific
site
disease.
Furthermore,
antimicrobial
properties
terbium
induced
via
reactive
oxygen
species
(ROS)
cause
oxidative
damage
cell
membrane
nuclei
living
organisms,
ion
release,
surface
charge
interaction,
thus
creating
or
exhibiting
excellent
antioxidant
characteristics.
Moreover,
recent
tissue
engineering,
wound
healing,
anticancer
activity,
etc.,
angiogenesis,
proliferation,
promotion
growth
factors,
biocompatibility,
cytotoxicity
mitigation,
anti-inflammatory
potentials,
make
this
nanoparticle
anticipate
a
future
epoch
nanomaterials.
stand
as
game
changer
realm
research,
proffering
array
possibilities,
from
revolutionary
imaging
techniques
advanced
drug
systems.
Their
unique
including
luminescence,
magnetic
characteristics,
have
redefined
boundaries
what
can
be
achieved
biomedicine.
This
review
primarily
delves
into
various
mechanisms
involved
physicochemical
article
explains
potential
with
in-depth
significant
individual
literature.
additionally
stands
first
instance
furnish
"single-platted"
comprehensive
acquaintance
shaping
healthcare
well
limitations
overcoming
strategies
that
require
exploration
before
being
trialed
clinical
settings.
Nano-Micro Letters,
Journal Year:
2022,
Volume and Issue:
14(1)
Published: Aug. 4, 2022
Coronavirus
disease
2019
(COVID-19)
is
a
highly
contagious
caused
by
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2).
The
gold
standard
method
for
the
diagnosis
of
SARS-CoV-2
depends
on
quantitative
reverse
transcription-polymerase
chain
reaction
till
now,
which
time-consuming
and
requires
expensive
instrumentation,
confirmation
variants
relies
further
sequencing
techniques.
Herein,
we
first
proposed
robust
technique-methodology
electrochemical
CRISPR
sensing
with
advantages
rapid,
sensitivity
specificity
detection
variant.
To
enhance
capability,
electrodes
are
uniformly
decorated
electro-deposited
nanoparticles.
Using
DNA
template
identical
to
Delta
spike
gene
sequence
as
model,
our
biosensor
exhibits
excellent
analytical
limit
(50
fM)
high
linearity
(R2
=
0.987)
over
six
orders
magnitude
dynamic
range
from
100
fM
10
nM
without
any
nucleic-acid-amplification
assays.
can
be
completed
within
1
h
stability
benefits
CRISPR-Cas
system.
Furthermore,
based
wireless
micro-electrochemical
platform,
reveals
promising
application
ability
in
point-of-care
testing.
Abstract
In
vitro
diagnosis
(IVD)
is
one
vital
component
of
medical
tests
that
detects
biological
samples
tissues
or
bio‐fluids.
Recently,
mass
spectrometry
and
spectroscopy
have
been
increasingly
employed
in
the
field
IVD,
due
to
their
high
accuracy,
facile
sample
preparation,
rapid
detection.
Notably,
large
datasets
generated
by
these
two
technology
methods
provide
a
wealth
information
but
subsequently
involve
complex
time‐consuming
processing
works.
Machine
learning
(ML),
an
important
branch
artificial
intelligence
(AI),
has
emerged
as
promising
solution
for
decoding
big
data.
ML
imitates
human
brain
process
data,
significantly
improving
accuracy
efficiency
compared
with
traditional
methods.
this
review,
we
first
introduce
commonly
used
algorithms
advanced
techniques
respectively.
The
are
summarized
four
aspects
according
different
tasks.
Then,
combinations
spectrometry,
spectroscopy,
multi‐modal
analysis
IVD
presented,
roles
elucidated
some
representative
examples.
This
review
aims
systematic
comprehensive
summary
literature
on
ML‐assisted
spectroscopy.
We
believe
it
will
facilitate
researchers
select
suitable
supplementing
existing
detection
develop
potential
coupling
more
ML,
thus
promoting
development
IVD.
Small Methods,
Journal Year:
2022,
Volume and Issue:
6(10)
Published: Sept. 16, 2022
Abstract
Infectious
pathogens
cause
severe
human
illnesses
and
great
deaths
per
year
worldwide.
Rapid,
sensitive,
accurate
detection
of
is
importance
for
preventing
infectious
diseases
caused
by
optimizing
medical
healthcare
systems.
Inspired
a
microbial
defense
system
(i.e.,
CRISPR/
CRISPR‐associated
proteins
(Cas)
system,
an
adaptive
immune
protecting
microorganisms
from
being
attacked
invading
species),
many
new
biosensors
have
been
successfully
developed
widely
applied
in
the
viruses
pathogenic
bacteria.
Moreover,
advanced
nanotechnologies
also
integrated
into
these
to
improve
their
stability,
sensitivity,
accuracy.
In
this
review,
recent
advance
CRISPR/Cas
systems‐based
nano/biosensors
applications
bacteria
are
comprehensively
reviewed.
First
all,
categories
working
principles
systems
establishing
simply
introduced.
Then,
design
construction
discussed.
end,
attentions
focused
on
Impressively,
remaining
opportunities
challenges
further
development
system‐based
promising
proposed.
