Acta Biomaterialia, Journal Year: 2023, Volume and Issue: 159, P. 247 - 258
Published: Jan. 29, 2023
Language: Английский
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: July 17, 2024
Abstract Cationic polymers have great potential for cancer therapy due to their unique interactions with cells. However, clinical application remains limited by high toxicity. Here we show a cell membrane-targeting cationic polymer antineoplastic activity (P mt ) and second near-infrared (NIR-II) fluorescent biodegradable photosensitizer Bodipy units reactive oxygen species (ROS) responsive thioketal bonds ). Subsequently, these two can self-assemble into nanoparticles (denoted mt-NP which could further accumulate at the tumor destroy membranes through electrostatic interactions, resulting in membrane destabilization. Meanwhile, produces ROS induce damage membranes, proteins, DNAs kill cells concertedly, finally lysis death. This work highlights use of light spatially temporarily control photodynamic therapy, photo-immunotherapy, NIR-II fluorescence bio-imaging.
Language: Английский
Citations
10
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(33)
Published: March 22, 2024
Abstract Sonodynamic therapy (SDT) has demonstrated significant potential in addressing multidrug‐resistant bacterial infections due to its noninvasive nature and independence from antibiotics light sources. However, the majority of current sonosensitizers exhibit aggregation‐caused quenching (ACQ), leading low reactive oxygen species (ROS) generation efficiency. Herein, a novel nonplanar structured sonodynamic (4,4‐difluoro‐4‐boron‐3a,4‐diaza‐indandiene) BODIPY derivative, BODN, with aggregation‐induced emission (AIE) properties, rapid substantial ROS by ultrasound is introduced. The BODN co‐assembled commercial amphiphilic polymer, mDSPE‐PEG 2000 , forming nanoparticles (BODN‐NP). Under conditions, BODN‐NP demonstrates potent antimicrobial activity improves inflammatory response promote healing wounds infected both Staphylococcus aureus methicillin‐resistant . This work expands use AIE materials provides new perspectives for innovative solutions against infections.
Language: Английский
Citations
9
ACS Applied Materials & Interfaces, Journal Year: 2022, Volume and Issue: 14(25), P. 29302 - 29314
Published: June 16, 2022
Solar energy-facilitated materials are promising to solve energy problems by converting clean solar thermal energy. However, heat loss of photothermal still limits the conversion phenomenon. Herein, we designed bio-inspired hollow carbon microtubes (HCMTs) one-step carbonization renewable cotton fibers, which can avoid complex preparation procedures template method. Similar polar bears, construction efficiently reduce loss, improves utilization light and property. The HCMTs be applied on a variety substrates obtain multifunctional protective coatings. temperature coating rapidly warm up 97.7 °C under 1 kW/m2 sun irradiation. In addition, coatings show excellent superhydrophobic property (CA 161.5 ± 0.9°), prevent adhesion contaminant maintain long-time surface. Also, is able withstand sandpaper abrasion, repeat tape-peeling, tribological friction without losing properties, indicating remarkable mechanical stability. Furthermore, high-temperature calcination (400 °C), UV radiation, corrosive liquid erosion, exhibits prominent chemical More importantly, combination active deicing passive anti-icing effectively formation accumulation ice outstanding environmental adaptability greatly extend its lifespan meet long-term service conditions.
Language: Английский
Citations
30
Nanomaterials, Journal Year: 2023, Volume and Issue: 13(15), P. 2269 - 2269
Published: Aug. 7, 2023
Photothermal therapy has the advantages of non-invasiveness, low toxicity, simple operation, a broad spectrum antibacterial ability, and non-proneness to developing drug resistance, which provide it with irreplaceable superiority in fighting against microbial infection. The effect photothermal is closely related choice agent. Conjugated nanomaterials are potential candidates for agents because their easy modification, excellent conversion efficiency, good photostability, biodegradability. In this paper, application based on conjugated antimicrobial treatment reviewed, including small molecules, oligomers, polymers, pseudo-conjugated polymers. At same time, combination (PTT) photodynamic (PDT) briefly introduced. Finally, research status, limitations, prospects using as discussed.
Language: Английский
Citations
21
Acta Biomaterialia, Journal Year: 2023, Volume and Issue: 159, P. 247 - 258
Published: Jan. 29, 2023
Language: Английский
Citations
19