Forum, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 21, 2025
Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)
Published: Feb. 20, 2025
The progression of malignant tumors leads to the development secondary in various organs, including bones, brain, liver, and lungs. This metastatic process severely impacts prognosis patients, significantly affecting their quality life survival rates. Research efforts have consistently focused on intricate mechanisms underlying this corresponding clinical management strategies. Consequently, a comprehensive understanding biological foundations tumor metastasis, identification pivotal signaling pathways, systematic evaluation existing emerging therapeutic strategies are paramount enhancing overall diagnostic treatment capabilities for tumors. However, current research is primarily metastasis within specific cancer types, leaving significant gaps our complex cascade, organ-specific tropism mechanisms, targeted treatments. In study, we examine sequential processes elucidate driving organ-tropic systematically analyze tumors, those tailored organ involvement. Subsequently, synthesize most recent advances technologies challenges opportunities encountered pertaining bone metastasis. Our objective offer insights that can inform future practice crucial field.
Language: Английский
Citations
7
Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)
Published: Aug. 27, 2024
Abstract The development of drug resistance remains a major challenge in cancer treatment. Ferroptosis, unique type regulated cell death, plays pivotal role inhibiting tumour growth, presenting new opportunities treating chemotherapeutic resistance. Accumulating studies indicate that epigenetic modifications by non-coding RNAs (ncRNA) can determine vulnerability to ferroptosis. In this review, we first summarize the growth/development. Then, core molecular mechanisms ferroptosis, its upstream regulation, and downstream effects on Finally, review recent advances understanding how ncRNAs regulate ferroptosis from such modulate This aims enhance general ncRNA-mediated regulatory which highlighting ncRNA-ferroptosis axis as key druggable target overcoming
Language: Английский
Citations
16
Drug Resistance Updates, Journal Year: 2024, Volume and Issue: 77, P. 101140 - 101140
Published: Aug. 16, 2024
Membrane protein-mediated resistance is a multidisciplinary challenge that spans fields such as medicine, agriculture, and environmental science. Understanding its complexity devising innovative strategies are crucial for treating diseases like cancer managing resistant pests in agriculture. This paper explores the dual nature of mechanisms across different organisms: On one hand, animals, bacteria, fungi, plants, insects exhibit convergent evolution, leading to development similar mechanisms. other influenced by diverse pressures structural differences among organisms, they also demonstrate divergent characteristics. prevalent insects, reflecting their shared survival evolved through evolution address challenges. However, variations ecological environments biological characteristics result differing responses resistance. Therefore, examining these not only enhances our understanding adaptive but provides theoretical support insights addressing drug advancing pharmaceutical development.
Language: Английский
Citations
10
Journal of Hematology & Oncology, Journal Year: 2025, Volume and Issue: 18(1)
Published: March 18, 2025
In the domain of addressing cancer resistance, challenges such as limited effectiveness and treatment resistance remain persistent. Hypoxia is a key feature solid tumors strongly associated with poor prognosis in patients. Another significant portion development acquired drug attributed to tumor stemness. Cancer stem cells (CSCs), small cell subset self-renewal proliferative abilities, are crucial for initiation, metastasis, intra-tumoral heterogeneity. Studies have shown association between hypoxia CSCs context resistance. Recent studies reveal strong link stemness, which together promote survival progression during treatment. This review elucidates interplay CSCs, well their correlation therapeutic drugs. Targeting pivotal genes stemness holds promise novel therapeutics combat
Language: Английский
Citations
2
Cancers, Journal Year: 2024, Volume and Issue: 16(9), P. 1727 - 1727
Published: April 29, 2024
The tumor microenvironment (TME), a complex assembly of cellular and extracellular matrix (ECM) components, plays crucial role in driving progression, shaping treatment responses, influencing metastasis. This narrative review focuses on the cutaneous squamous cell carcinoma (cSCC) stroma, highlighting its key constituents their dynamic contributions. We examine how significant changes within cSCC ECM—specifically, alterations fibronectin, hyaluronic acid, laminins, proteoglycans, collagens—promote cancer metastasis, drug resistance. composition TME is also explored, detailing intricate interplay cancer-associated fibroblasts (CAFs), mesenchymal stem cells (MSCs), endothelial cells, pericytes, adipocytes, various immune populations. These diverse players modulate development, angiogenesis, responses. Finally, we emphasize TME’s potential as therapeutic target. Emerging strategies discussed this include harnessing system (adoptive transfer, checkpoint blockade), hindering disrupting CAF activity, manipulating ECM components. approaches underscore vital that deciphering interactions advancing therapy. Further research illuminating these relationships will uncover new avenues for developing more effective treatments cSCC.
Language: Английский
Citations
9
Pathogens, Journal Year: 2024, Volume and Issue: 13(10), P. 835 - 835
Published: Sept. 27, 2024
The protozoan parasite Leishmania causes leishmaniasis, a neglected tropical disease, that disproportionately affects underdeveloped countries. This disease has major health, economic, and social implications, particularly because of the limited treatment options, high cost, severe side effects associated with available therapeutics, rate failure caused by parasites’ growing resistance to current medications. In this review, we describe first common strategies used pathogens develop drug then focus on arsenal drugs treat their modes action, molecular mechanisms contributing in spp., including role genomic, transcriptional, translational control. We more specifically our recent discovery reprogramming as driver leading coordinated changes translation transcripts orchestrating metabolome lipidome support resistance. A thorough understanding these is essential identify key elements needed combat improve leishmaniasis methods.
Language: Английский
Citations
9
IUBMB Life, Journal Year: 2024, Volume and Issue: 76(11), P. 883 - 921
Published: Aug. 1, 2024
Cancer drug resistance poses a significant obstacle to successful chemotherapy, primarily driven by the activity of ATP-binding cassette (ABC) transporters, which actively efflux chemotherapeutic agents from cancer cells, reducing their intracellular concentrations and therapeutic efficacy. Recent studies have highlighted pivotal role long noncoding RNAs (lncRNAs) in regulating this resistance, positioning them as crucial modulators ABC transporter function. lncRNAs, once considered transcriptional noise, are now recognized for complex regulatory capabilities at various cellular levels, including chromatin modification, transcription, post-transcriptional processing. This review synthesizes current research demonstrating how lncRNAs influence modulating expression transporters. can act molecular sponges, sequestering microRNAs that would otherwise downregulate genes. Additionally, they alter epigenetic landscape these genes, affecting activity. Mechanistic insights reveal contribute thereby altering drugs promoting resistance. Understanding interactions provides new perspective on basis chemoresistance, emphasizing network knowledge not only deepens our understanding biological mechanisms underlying but also suggests novel strategies. In conclusion, intricate interplay between transporters is developing innovative solutions combat underscoring importance continued field.
Language: Английский
Citations
7
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(9), P. 1120 - 1120
Published: Aug. 24, 2024
Natural photosensitizers (PS) are compounds derived from nature, with photodynamic properties. PSs have a similar action to that of commercial PSs, where cancer cell death occurs by necrosis, apoptosis, and autophagy through ROS generation. garnered great interest over the last few decades because their high biocompatibility good photoactivity. Specific wavelengths could cause phytochemicals produce harmful for therapy (PDT). However, natural some shortcomings, such as reduced solubility lower uptake, making them less appropriate PDT. Nanotechnology offers an opportunity develop suitable carriers various PDT applications. Various nanoparticles been developed improve outcome enhanced solubility, optical adsorption, tumor targeting. Multidrug resistance (MDR) is phenomenon in which cells wide range structurally functionally unrelated drugs. Over decade, several researchers extensively studied effect PS-based treatment (PDT) on MDR cells. Though outcomes clinical trials were inconclusive, significant advancement still required before can be used agent treating tumors. This review addresses increasing literature progression efficacy PDT, emphasizing importance developing new nano-based fight against features photosensitizing regimen.
Language: Английский
Citations
7
Nanomaterials, Journal Year: 2024, Volume and Issue: 14(17), P. 1424 - 1424
Published: Aug. 31, 2024
The increasing incidence of breast cancers (BCs) in the world population and their complexity high metastatic ability are serious concerns for healthcare systems. Despite significant progress medicine made recent decades, efficient treatment invasive still remains challenging. Chemotherapy, a fundamental systemic method, is burdened with severe adverse effects, efficacy limited by resistance development risk disease recurrence. Also, current diagnostic methods have certain drawbacks, attracting attention to idea developing novel, more sensitive detection therapeutic modalities. It seems solution these issues can be provided nanotechnology. Particularly, quantum dots (QDs) been extensively evaluated as potential targeted drug delivery vehicles and, simultaneously, sensing bioimaging probes. These fluorescent nanoparticles offer unlimited possibilities surface modifications, allowing attachment biomolecules, such antibodies or proteins, molecules, among others. In this work, we discuss applicability QDs cancer diagnostics light knowledge. We begin introducing molecular histopathological features BCs, standard regimens, methods. Further, QDs, along uptake, biodistribution patterns, cytotoxicity, described. Based on reports published years, present research possible QD use improving BC chemotherapeutic photosensitizing agents, stages development. also address limitations open questions regarding topic.
Language: Английский
Citations
7
Pharmacological Research, Journal Year: 2024, Volume and Issue: unknown, P. 107430 - 107430
Published: Sept. 1, 2024
Language: Английский
Citations
7