Glutathione peroxidase-like nanozymes: mechanism, classification, and bioapplication

Biomaterials Science, Journal Year: 2023, Volume and Issue: 11(7), P. 2292 - 2316

Published: Jan. 1, 2023

The field of nanozymes is developing rapidly. In particular, glutathione peroxidase (GPx)-like nanozymes, which catalytically reduce H2O2/organic hydroperoxides to H2O/alcohols, have attracted considerable attention. GPx-like are powerful antioxidant enzymes known combat oxidative stress. They broad applications, including cytoprotection, anti-inflammation, neuroprotection, tumor therapy, and anti-aging. Although much progress has been made, not well discussed or fully reviewed as other nanozymes. This review aims summarize recent advances on from the vantage point mechanism, classification, bioapplication. Future prospects for advancing their design application also discussed.

Language: Английский

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A DNA‐Gated and Self‐Protected Bioorthogonal Catalyst for Nanozyme‐Assisted Safe Cancer Therapy

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(32)

Published: June 3, 2023

Transition metal catalysts (TMCs) mediated bioorthogonal uncaging catalysis has sparked increasing interest in prodrug activation. However, due to their "always-on" catalytic activity as well the complex and catalytic-detrimental intracellular environment, biosafety therapeutic efficiency of TMCs are unsatisfactory. Herein, a DNA-gated self-protected catalyst been designed by modifying nanozyme-Pd0 with highly programmable nucleic acid (DNA) molecules achieve efficient drug synthesis for cancer therapy. Monolayer DNA could endow targeting perform gatekeeper selective activation within cells. Meanwhile, prepared graphitic nitrogen-doped carbon nanozyme glutathione peroxidase (GPx) catalase (CAT)-like activities improve environment prevent from being inactivated sensitize subsequent chemotherapy. Overall, we believe that our work will promote development secure systems provide new insights into novel antineoplastic platforms.

Language: Английский

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Platelet membrane fusion liposome loaded with type I AIE photosensitizer to induce chemoresistance cancer pyroptosis and immunogenic cell death for enhancing cancer immunotherapy

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 476, P. 146276 - 146276

Published: Oct. 11, 2023

Language: Английский

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Antitumor Effects of a Distinct Sonodynamic Nanosystem through Enhanced Induction of Immunogenic Cell Death and Ferroptosis with Modulation of Tumor Microenvironment

JACS Au, Journal Year: 2023, Volume and Issue: 3(5), P. 1507 - 1520

Published: May 9, 2023

Sonodynamic therapy (SDT) holds great promise to be applied for cancer in clinical settings. However, its poor therapeutic efficacy has limited applications owing the apoptosis-resistant mechanism of cells. Moreover, hypoxic and immunosuppressive tumor microenvironment (TME) also weakens immunotherapy solid tumors. Therefore, reversing TME remains a formidable challenge. To circumvent these critical issues, we developed an ultrasound-augmented strategy regulate by utilizing HMME-based liposomal nanosystem (HB liposomes), which can synergistically promote induction ferroptosis/apoptosis/immunogenic cell death (ICD) initiate reprograming TME. The RNA sequencing analysis demonstrated that apoptosis, hypoxia factors, redox-related pathways were modulated during treatment with HB liposomes under ultrasound irradiation. vivo photoacoustic imaging experiment showed enhanced oxygen production TME, alleviated hypoxia, helped overcome tumors, consequently improving SDT efficiency. More importantly, extensively induced ICD, resulting T-cell recruitment infiltration, normalizes facilitates antitumor immune responses. Meanwhile, system combined PD1 checkpoint inhibitor achieves superior synergistic inhibition. Both vitro results indicate act as sonodynamic adjuvant is able induce ferroptosis/apoptosis/ICD via generated lipid-reactive oxide species reprogram due ICD induction. This integrating supply, reactive generation, excellent effective modulation efficient therapy.

Language: Английский

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Biodegradable CuMoO₄ Nanodots with Multienzyme Activities for Multimodal Treatment of Tumor

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(22)

Published: May 24, 2023

Due to their complexity and variability, tumors need be treated with multimodal combined therapy, which requires the development of therapeutic agents that can provide effects. Herein, CuMoO4 nanodots smaller than 10 nm prepared by simple hydrothermal method are reported. These well dispersed in water have good biosafety biodegradability. Further studies show these also present multienzyme activities, such as catalase, peroxidase glutathione peroxidase. In addition, exhibit high photothermal conversion efficiency (41%) under 1064 near-infrared laser irradiation. vitro vivo experimental results indicate effectively inhibit instinctive regulation tumor cells oxidative stress, sustained treatment achieve synergistic ferroptosis, trigger immune responses immunogenic cell death. It is worth mentioning cause cuproptosis cells. This study provides a promising nanoplatform for therapy cancer.

Language: Английский

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