Deep Insight of Design, Mechanism, and Cancer Theranostic Strategy of Nanozymes

Nano-Micro Letters, Journal Year: 2023, Volume and Issue: 16(1)

Published: Nov. 21, 2023

Since the discovery of enzyme-like activity Fe

Language: Английский

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Nanozyme enabled protective therapy for neurological diseases

Nano Today, Journal Year: 2024, Volume and Issue: 54, P. 102142 - 102142

Published: Jan. 3, 2024

Language: Английский

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Advances in design and preparation of nanozymes and their applications for constructing higher sensitive lateral flow assays

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 510, P. 215797 - 215797

Published: April 4, 2024

Language: Английский

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Rational Design of Nanozymes for Engineered Cascade Catalytic Cancer Therapy

Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Nanozymes have shown significant potential in cancer catalytic therapy by strategically catalyzing tumor-associated substances and metabolites into toxic reactive oxygen species (ROS) situ, thereby inducing oxidative stress promoting cell death. However, within the complex tumor microenvironment (TME), rational design of nanozymes factors like activity, reaction substrates, TME itself significantly influence efficiency ROS generation. To address these limitations, recent research has focused on exploring that affect activity developing nanozyme-based cascade systems, which can trigger two or more processes tumors, producing therapeutic achieving efficient stable with minimal side effects. This area remarkable progress. Perspective provides a comprehensive overview nanozymes, covering their classification fundamentals. The regulation nanozyme strategies are discussed detail. Furthermore, representative paradigms for successful construction systems treatment summarized focus revealing underlying mechanisms. Finally, we current challenges future prospects development biomedical applications.

Language: Английский

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Recent Advancements in the Formulation of Nanomaterials-Based Nanozymes, Their Catalytic Activity, and Biomedical Applications

ACS Applied Bio Materials, Journal Year: 2023, Volume and Issue: 6(9), P. 3577 - 3599

Published: Aug. 17, 2023

Nanozymes are nanoparticles with intrinsic enzyme-mimicking properties that have become more prevalent because of their ability to outperform conventional enzymes by overcoming drawbacks related stability, cost, and storage. the potential manipulate active sites natural enzymes, which is why they considered promising candidates function as enzyme mimetics. Several microscopy- spectroscopy-based techniques been used for characterization nanozymes. To date, a wide range nanozymes, including catalase, oxidase, peroxidase, superoxide dismutase, designed effectively mimic enzymes. The activity nanozymes can be controlled regulating structural morphological aspects multifaceted benefits, exploited on large scale application in biomedical sector. versatility aids monitoring treating cancer, other neurodegenerative diseases, metabolic disorders. Due compelling advantages significant research advancements made this area. Although act potent mimetics specificities suboptimal, there still room diversification analytical purposes. Designing diverse nanozyme systems sensitive one or substrates through specialized has subject an in-depth study. Hence, we believe stimuli-responsive may open avenues diagnosis treatment fusing catalytic nanomaterial systems.

Language: Английский

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Enzyme-mimetic antioxidant nanomaterials for ROS scavenging: Design, classification, and biological applications

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 500, P. 215536 - 215536

Published: Nov. 4, 2023

Language: Английский

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Recent Applications of Melanin-like Nanoparticles as Antioxidant Agents

Antioxidants, Journal Year: 2023, Volume and Issue: 12(4), P. 863 - 863

Published: April 2, 2023

Nanosized antioxidants are highly advantageous in terms of versatility and pharmacokinetics, with respect to conventional molecular ones. Melanin-like materials, artificial species inspired by natural melanin, combine recognized antioxidant (AOX) activity a unique preparation modification. Due this documented biocompatibility, melanin has been incorporated into variety nanoparticles (NP) order give new platforms for nanomedicine enhanced AOX activity. In review article, we first discuss the chemical mechanisms behind materials context inhibition radical chain reaction responsible peroxidation biomolecules. We also focus briefly on properties melanin-like NP, considering effect parameters such as size, methods surface functionalization them. Then, consider most recent relevant applications NPs that able counteract ferroptosis be involved treatment important diseases affect, e.g., cardiovascular nervous systems, well kidneys, liver articulations. A specific section will dedicated cancer treatment, since role is still very debated. Finally, propose future strategies development better understanding materials. particular, composition structure these debated, they present high level variability. Thus, mechanism interaction nanostructures different radicals reactive would design more effective nano-agents.

Language: Английский

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Metal-free multifunctional nanozymes mimicking endogenous antioxidant system for acute kidney injury alleviation

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 477, P. 147048 - 147048

Published: Nov. 1, 2023

Language: Английский

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Recent trends in nanozyme research and their potential therapeutic applications

Current Research in Biotechnology, Journal Year: 2024, Volume and Issue: 7, P. 100205 - 100205

Published: Jan. 1, 2024

Nanozymes are a class of nanoparticles that can mimic enzyme activity and be used for various applications in modern clinical therapy. It has recently been observed nanozymes have multi-enzyme mimicking activities, highly stable, versatile easily modified. Moreover, they high catalytic efficiency, recovery rates, improved substrate specificity suitable mass production. The mechanisms mainly include catalase, peroxidase, oxidase, hydrolase superoxide dismutase-like which enable to as potential therapeutics against plethora infectious lifestyle disorders. cancer, inflammatory diseases, neurodegenerative neurological disorders, bacterial, fungal viral infections, wounds diseases associated with Reactive Oxygen Species. purpose writing this review is provide comprehensive compilation novel research work taken place the last few years regarding use We compiled kinds elaborated on their anti-tumorigenic, antioxidant, anti-inflammatory, antibacterial, antifungal, antiviral, neuroprotective roles. Their modes action enzymatic targets also discussed. types synthesis summarized, along interactions nanozymes. Furthermore, strategies enhance compatibility between analyzed. Major focus laid therapeutic challenges future perspectives using therapy debated later sections.

Language: Английский

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Ultrasmall Cu₂O@His Nanozymes with RONS Scavenging Capability for Anti-inflammatory Therapy

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(3), P. 3116 - 3125

Published: Jan. 15, 2024

High concentrations of reactive oxygen and nitrogen species (RONS) are key characteristics inflammatory sites. Scavenging RONS at the site inflammation is an effective therapeutic strategy. This study introduces ultrasmall Cu2O@His nanoparticles with RONS-scavenging ability for treatment bowel disease (IBD) in mice. The strong coordination between atom histidine (His) copper enhances dispersion stability Cu2O@His. Due to their small size large surface area, exhibits outstanding RONS-clearing ability. Importantly, can target mitochondrial sites repair damaged mitochondria. With excellent scavenging ability, demonstrates good efficacy treating mouse IBD. work provides a new paradigm developing nanozymes multiple abilities.

Language: Английский

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