Small,
Journal Year:
2023,
Volume and Issue:
19(49)
Published: Aug. 27, 2023
Alzheimer's
disease
(AD)
is
a
severe
neurodegenerative
condition
characterized
by
inflammation,
beta-amyloid
(Aβ)
plaques,
and
neurodegeneration,
which
currently
lack
effective
treatments.
Chiral
nanomaterials
have
emerged
as
promising
option
for
treating
disorders
due
to
their
high
biocompatibility,
strong
sustained
release
ability,
specific
enantiomer
selectivity.
The
development
of
stimulus-responsive
chiral
nanomaterial,
UiO-66-NH2
@l-MoS2
QDs@PA-Ni
(MSP-U),
the
treatment
AD
reported.
MSP-U
found
stimulate
neural
stem
cell
(NSCs)
differentiation,
promote
in
situ
hydrogen
(H2
)
production,
clear
Aβ
plaques.
l-MoS2
QDs
modified
with
l-Cysteine
(l-Cys)
effectively
enhance
differentiation
NSCs
into
neurons
through
circularly
polarized
near-infrared
radiation.
Doped-phytic
acid
nickel
(PA-Ni)
improves
activity
scavenging
reactive
oxygen
species
at
lesion
site
via
photocatalytic
H2
production.
Loading
UiO-66
type
metal
oxide
suppresses
electron-hole
recombination
effect,
thereby
achieving
rapid
charge
separation
improving
transport
photogenerated
electrons,
leading
significantly
improved
production
efficiency.
photothermal
effect
also
clears
generated
In
vivo
evaluations
show
that
spatial
cognition
memory,
suggesting
potential
candidate
using
nanomaterials.
Small,
Journal Year:
2023,
Volume and Issue:
19(38)
Published: May 22, 2023
Abstract
Chirality
is
a
universal
phenomenon
in
molecular
and
biological
systems,
denoting
an
asymmetric
configurational
property
where
object
cannot
be
superimposed
onto
its
mirror
image
by
any
kind
of
translation
or
rotation,
which
ubiquitous
on
the
scale
from
neutrinos
to
spiral
galaxies.
plays
very
important
role
life
system.
Many
molecules
body
show
chirality,
such
as
“codebook”
earth's
diversity‐DNA,
nucleic
acid,
etc.
Intriguingly,
living
organisms
hierarchically
consist
homochiral
building
blocks,
for
example,
l
‐amino
acids
d
‐sugars
with
unknown
reason.
When
chirality
interact
these
chiral
factors,
only
one
conformation
favors
positive
development
life,
that
is,
host
environment
can
selectively
conformations.
The
differences
interactions
are
often
manifested
recognition,
mutual
matching,
molecules,
means
stereoselectivity
produce
changes
pharmacodynamics
pathology.
Here,
latest
investigations
summarized
including
construction
applications
materials
based
natural
small
source,
biomacromolecules
sources,
material
synthesized
design
source.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(18)
Published: Jan. 19, 2024
Abstract
Machine
learning
holds
significant
research
potential
in
the
field
of
nanotechnology,
enabling
nanomaterial
structure
and
property
predictions,
facilitating
materials
design
discovery,
reducing
need
for
time‐consuming
labor‐intensive
experiments
simulations.
In
contrast
to
their
achiral
counterparts,
application
machine
chiral
nanomaterials
is
still
its
infancy,
with
a
limited
number
publications
date.
This
despite
great
advance
development
new
sustainable
high
values
optical
activity,
circularly
polarized
luminescence,
enantioselectivity,
as
well
analysis
structural
chirality
by
electron
microscopy.
this
review,
an
methods
used
studying
provided,
subsequently
offering
guidance
on
adapting
extending
work
nanomaterials.
An
overview
within
framework
synthesis–structure–property–application
relationships
presented
insights
how
leverage
study
these
highly
complex
are
provided.
Some
key
recent
reviewed
discussed
Finally,
review
captures
achievements,
ongoing
challenges,
prospective
outlook
very
important
field.
Advanced Science,
Journal Year:
2022,
Volume and Issue:
9(29)
Published: Aug. 25, 2022
The
differentiation
of
neural
stem
cells
via
nanomaterials
has
attracted
attention
and
become
a
potential
tool.
However,
the
chirality
effect
in
cell
not
been
investigated.
Here,
this
study
shows
that
chiral
nanoparticles
(NPs)
with
strong
can
efficiently
accelerate
mouse
(NSCs)
into
neurons
under
near-infrared
(NIR)
light
illumination.
L-type
NPs
are
1.95
times
greater
than
D-type
promoting
NSCs
due
to
their
1.47-fold
endocytosis
efficiency.
Whole
gene
expression
map
analysis
reveals
circularly
polarized
illumination
irradiation
significantly
upregulate
Map2,
Yap1,
Taz
genes,
resulting
mechanical
force,
cytoskeleton
protein
action,
accelerated
differentiation.
In
vivo
experiments
show
successful
further
alleviate
symptoms
Alzheimer's
disease
mice.
Moreover,
clearance
on
amyloid
hyperphosphorylated
p-tau
reachs
68.24%
66.43%,
respectively,
synergy
NIR
irradiation.
findings
suggest
may
have
advantages
guiding
development
be
used
biomedicine.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(11), P. 9850 - 9869
Published: June 2, 2023
The
nanoscale
properties
of
nanomaterials,
especially
nanoparticles,
including
size,
shape,
and
surface
charge,
have
been
extensively
studied
for
their
impact
on
nanomedicine.
Given
the
inherent
chiral
nature
biological
systems
high
enantiomeric
selectivity,
there
is
rising
interest
to
manipulate
chirality
nanomaterials
enhance
biomolecular
interactions
improve
nanotherapeutics.
Chiral
nanostructures
are
currently
more
prevalently
used
in
biosensing
diagnostic
applications
owing
distinctive
physical
optical
properties,
but
they
hold
great
promise
use
In
this
Review,
we
first
discuss
stereospecific
between
biomolecules
before
comparing
synthesis
characterization
methods
nanoparticles
nanoassemblies.
Finally,
examine
nanotherapeutics
cancer,
immunomodulation,
neurodegenerative
diseases
propose
plausible
mechanisms
which
interact
with
cells
manipulation.
This
Review
a
timely
reminder
arsenal
modifications
boost
research
Stem Cell Research & Therapy,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: May 7, 2024
Abstract
Background
Alzheimer’s
disease
(AD)
is
a
prevalent
form
of
dementia
leading
to
memory
loss,
reduced
cognitive
and
linguistic
abilities,
decreased
self-care.
Current
AD
treatments
aim
relieve
symptoms
slow
progression,
but
cure
elusive
due
limited
understanding
the
underlying
mechanisms.
Main
content
Stem
cell
technology
has
potential
revolutionize
research.
With
ability
self-renew
differentiate
into
various
types,
stem
cells
are
valuable
tools
for
modeling,
drug
screening,
therapy.
Recent
advances
have
broadened
our
beyond
deposition
amyloidβ
(Aβ)
or
tau
proteins
in
encompass
risk
genes,
immune
system
disorders,
neuron–glia
mis-communication,
relying
heavily
on
cell-derived
models.
These
cell-based
models
(e.g.,
organoids
microfluidic
chips)
simulate
vivo
pathological
processes
with
extraordinary
spatial
temporal
resolution.
technologies
alleviate
pathology
through
pathways,
including
immunomodulation,
replacement
damaged
neurons,
neurotrophic
support.
In
recent
years,
transplantation
glial
like
oligodendrocytes
infusion
exosomes
become
hot
research
topics.
Conclusion
Although
therapies
face
several
challenges,
such
as
extended
culture
time
low
differentiation
efficiency,
they
still
show
considerable
treatment
likely
preferred
Brain‐X,
Journal Year:
2023,
Volume and Issue:
1(3)
Published: July 28, 2023
Abstract
Alzheimer's
disease
(AD)
is
the
most
common
neurodegenerative
disorder
worldwide.
Because
of
complex
pathogenesis
AD
and
unique
location
lesions,
effective
clinical
treatment
strategies
for
this
remain
elusive.
However,
development
nanotechnology
has
allowed
a
new
era
to
emerge.
nanomedicines
are
products
interdisciplinary
research
that
enable
high
precision
targeted
delivery.
Additionally,
they
can
specifically
regulate
various
pathogenic
factors.
This
review
focuses
on
based
pathological
mechanisms
target
lesions.
We
also
discuss
precise
regulatory
effects
(including
nanomaterials
themselves)
proteins,
neuroinflammatory
molecules,
other
summarize
trials
have
examined
drugs,
highlighting
progress
in
their
translation.
Nanotechnology‐based
nascent
field,
complete
cure
distant
at
present;
therefore,
we
elaborate
shortcomings
current
nanomedicines.
Finally,
prospects
guide
future
