The quest for nanoparticle-powered vaccines in cancer immunotherapy

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Feb. 14, 2024

Abstract Despite recent advancements in cancer treatment, this disease still poses a serious threat to public health. Vaccines play an important role preventing illness by preparing the body's adaptive and innate immune responses combat diseases. As our understanding of malignancies their connection system improves, there has been growing interest priming fight more effectively comprehensively. One promising approach involves utilizing nanoparticle systems for antigen delivery, which shown potentiate as vaccines and/or adjuvants. In review, we comprehensively summarized immunological mechanisms while focusing specifically on applications various types nanoparticles field immunotherapy. By exploring these breakthroughs, hope identify significant challenges obstacles making nanoparticle-based adjuvants feasible clinical application. This review serves assess breakthroughs vaccinations shed light prospects potential barriers. doing so, aim inspire future immunotherapies that harness nanotechnology deliver effective targeted treatments. Graphical abstract

Language: Английский

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Nanomaterial-encapsulated STING agonists for immune modulation in cancer therapy

Biomarker Research, Journal Year: 2024, Volume and Issue: 12(1)

Published: Jan. 7, 2024

Abstract The cGAS-STING signaling pathway has emerged as a critical mediator of innate immune responses, playing crucial role in improving antitumor immunity through effector responses. Targeting the holds promise for overcoming immunosuppressive tumor microenvironments (TME) and promoting effective elimination. However, systemic administration current STING agonists faces challenges related to low bioavailability potential adverse effects, thus limiting their clinical applicability. Recently, nanotechnology-based strategies have been developed modulate TMEs robust immunotherapeutic encapsulation delivery within nanoparticles (STING-NPs) present an attractive avenue immunotherapy. This review explores range designed encapsulate agonists, highlighting benefits, including favorable biocompatibility, improved penetration, efficient intracellular agonists. also summarizes immunomodulatory impacts STING-NPs on TME, enhanced secretion pro-inflammatory cytokines chemokines, dendritic cell activation, cytotoxic T priming, macrophage re-education, vasculature normalization. Furthermore, offers insights into co-delivered nanoplatforms involving alongside agents such chemotherapeutic compounds, checkpoint inhibitors, antigen peptides, other adjuvants. These platforms demonstrate remarkable versatility inducing immunogenic responses ultimately amplifying

Language: Английский

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Metal coordination‐driven assembly of stimulator of interferon genes‐activating nanoparticles for tumor chemo‐immunotherapy

BMEMat, Journal Year: 2024, Volume and Issue: 2(2)

Published: Feb. 27, 2024

Abstract Activating the stimulator of interferon genes (STING) signaling pathway is critical for enhancing antitumor immunity and remodeling immunosuppressive tumor microenvironment (TME). Herein, we report preparation STING‐activating nanoparticles via metal coordination‐driven assembly a synthetic STING agonist (i.e., SR717) chemotherapeutic drug curcumin). After intravenous administration, assembled could efficiently accumulate in tumors to improve bioavailability SR717 trigger potent activation effective immune responses. Meanwhile, released curcumin evokes immunogenic cell death regulates amino acid metabolism by inhibiting indoleamine 2,3‐dioxygenase 1, leading reversal TME. The induced significantly inhibits growth primary, recurrent, metastatic tumors. are promising co‐delivery agonists drugs improved chemo‐immunotherapy.

Language: Английский

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Multifunctional nanocomposites modulating the tumor microenvironment for enhanced cancer immunotherapy

Bioactive Materials, Journal Year: 2023, Volume and Issue: 31, P. 440 - 462

Published: Sept. 6, 2023

Cancer immunotherapy has gained momentum for treating malignant tumors over the past decade. Checkpoint blockade and chimeric antigen receptor cell therapy (CAR-T) have shown considerable potency against liquid solid cancers. However, tumor microenvironment (TME) is highly immunosuppressive hampers effect of currently available cancer immunotherapies on overall treatment outcomes. Advancements in design engineering nanomaterials opened new avenues to modulate TME. Progress current nanocomposite technology can overcome immunosuppression trigger robust immunotherapeutic responses by integrating synergistic functions different molecules. We will review recent advancements nanomedical applications discuss specifically designed nanocomposites modulating TME immunotherapy. In addition, we provide information landscape clinical-stage

Language: Английский

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Nanomaterial-mediated modulation of the cGAS-STING signaling pathway for enhanced cancer immunotherapy

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 176, P. 51 - 76

Published: Jan. 17, 2024

Language: Английский

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PdRu bimetallic nanoalloys with improved photothermal effect for amplified ROS-mediated tumor therapy

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 3, 2025

An emerging strategy in cancer therapy involves inducing reactive oxygen species (ROS), specifically within tumors using nanozymes. However, existing nanozymes suffer from limitations such as low reactivity, poor biocompatibility, and limited targeting capabilities, hindering their therapeutic efficacy. In response, the PdRu@PEI bimetallic nanoalloys were constructed with well-catalytic activities effective separation of charges, which can catalyze hydrogen peroxide (H2O2) to toxic hydroxyl radical (·OH) under near-infrared laser stimulation. Through facilitating electron transfer enhancing active sites, enhanced peroxidase-like (POD-like) enzymatic activity glutathione (GSH) depletion abilities are boosted through a simple co-reduction process, leading promising anti-tumor activity. The between Pd Ru contributes POD-like Then, by oxidizing endogenous overexpressed GSH, cycling prevents GSH consuming ROS. Furthermore, surface plasmon resonance effect on ensures its photothermal performance local heating, further promoting integrated multi-modal approach has demonstrated significant anti-cancer effects vivo studies. exhibit high catalytic efficiency excellent offering valuable insights for development nano-catalysts/enzymes biomedical applications.

Language: Английский

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Combination of an LDH-based platform with microRNA for the treatment of myocardial Ischemia-Reperfusion injury by pyroptosis inhibition via the CaSR/PLCγ1/IP3R pathway

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160833 - 160833

Published: Feb. 1, 2025

Language: Английский

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Triple‐Combination Immunogenic Nanovesicles Reshape the Tumor Microenvironment to Potentiate Chemo‐Immunotherapy in Preclinical Cancer Models

Advanced Science, Journal Year: 2023, Volume and Issue: 10(15)

Published: April 5, 2023

Immune checkpoint blockade (ICB) therapies have had a tremendous impact on cancer therapy. However, most patients harbor poorly immunogenic tumor microenvironment (TME), presenting overwhelming de novo refractoriness to ICB inhibitors. To address these challenges, combinatorial regimens that employ chemotherapies and immunostimulatory agents are urgently needed. Here, combination chemoimmunotherapeutic nanosystem consisting of polymeric monoconjugated gemcitabine (GEM) prodrug nanoparticle decorated with an anti-programmed cell death-ligand 1 (PD-L1) antibody (αPD-L1) the surface stimulator interferon genes (STING) agonist encapsulated inside is developed. Treatment GEM nanoparticles upregulates PD-L1 expression in ICB-refractory tumors, resulting augmented intratumor drug delivery vivo synergistic antitumor efficacy via activation CD8

Language: Английский

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Tumor-Repopulating Cell-Derived Microparticle-Based Therapeutics Amplify the Antitumor Effect through Synergistic Inhibition of Chemoresistance and Immune Evasion

Molecular Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Traditional chemotherapy often encounters failure attributed to drug resistance mediated by tumor-repopulating cells (TRCs) and chemotherapy-triggered immune suppression. The effective inhibition of TRCs the mitigation drug-induced suppression are pivotal for successful chemotherapy. Here, TRC-derived microparticles (3D-MPs), characterized excellent tumor-targeting high TRC uptake properties, utilized deliver metformin chemotherapeutic doxorubicin ((DOX+Met)@3D-MPs). (DOX+Met)@3D-MPs efficiently enhance tumor accumulation highly internalized in TRCs. Additionally, significantly decrease upregulation P-glycoprotein expression intracellular retention, resulting increased sensitivity immunogenic cell death improved antitumor immunity. Importantly, also remarkably reduce chemotherapy-induced PD-L1 expression, alleviating facilitated PD-L1/PD-1 axis further immunological response against malignancy. These results underscore (DOX+Met)@3D-MPs' potential as a viable platform augmenting efficacy therapies.

Language: Английский

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Piezo‐Electrons Induced Endoplasmic Reticulum Protein Misfolding to Enhance Immune Checkpoint Blockage Cancer Therapy

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

Abstract The endoplasmic reticulum (ER) is a crucial organelle in eukaryotic cells that regulates protein synthesis, folding, and transport, playing vital role maintaining homeostasis functions. Tumor evade the immune surveillance killing of body by synthesizing checkpoint proteins ER, thereby inhibiting T cell‐mediated antitumor responses enhancing tumor tolerance, leading to poor efficacy cancer immunotherapy. Herein, an ultrasound‐triggered piezo‐nanomedicine designed with targeting function (BTO v ‐T ER ) achieve novel blockade therapy. Under ultrasound irradiation, BTO releases piezo‐electrons reducing properties disrupt redox cell reticulum, inducing misfolding apoptosis, which activates response. Meanwhile, due abnormal folding expression proteins, such as Programmed death ligand 1 (PD‐L1) downregulated, reactivating promoting strategy interfering processing various within via piezo‐catalysis provides approach for

Language: Английский

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