Advances and prospects of precision nanomedicine in personalized tumor theranostics DOI Creative Commons
Yuhang Mao,

Juanping Xie,

Fang Yang

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Dec. 5, 2024

Tumor, as the second leading cause of death globally, following closely behind cardiovascular diseases, remains a significant health challenge worldwide. Despite existence various cancer treatment methods, their efficacy is still suboptimal, necessitating development safer and more efficient strategies. Additionally, advancement personalized therapy offers further possibilities in treatment. Nanomedicine, promising interdisciplinary field, has shown tremendous potential prospects diagnosis cancer. As an emerging approach oncology, application nanomedicine primarily focuses on targeted drug delivery systems such passive targeting delivery, active environmentally responsive well imaging diagnostics tumor biomarker detection, cell vivo imaging. However, it faces challenges regarding safety, biocompatibility, other issues. This review aims to explore advances use nanomaterials field investigate developing therapies care, providing direction for clinical translation application.

Language: Английский

Engineered brain‐targeting exosome for reprogramming immunosuppressive microenvironment of glioblastoma DOI Creative Commons
Jun Yang, Yong Li,

Shaoping Jiang

et al.

Exploration, Journal Year: 2024, Volume and Issue: unknown

Published: June 26, 2024

Abstract The immunosuppressive microenvironment of glioblastoma multiforme (GBM) severely impacts the response to various treatments, including systemic chemotherapy. Targeted reprogramming GBM using RNA interference (RNAi) is largely restricted by poor brain delivery efficiency and targeting specificity. Herein, an acid‐cleavable transferrin (Tf) decorated engineering exosome‐based brain‐targeting system (ACTE) was proposed efficiently deliver small towards transform growth factor‐β (siTGF‐β) doxorubicin (DOX) site for combination chemo‐immunotherapy. siTGF‐β DOX co‐loaded ACTE, termed as DOX&siTGF‐β@ACTE (Ds@ACTE), designed specifically recognize Tf receptor (TfR) on blood‐brain barrier (BBB). Subsequently, Ds@ACTE undergoes acid‐responsive detachment within lysosome capillary endothelial cells, leading separation DOX&siTGF‐β@Exo (Ds@Exo) from Tf‐TfR complex enhanced BBB transcytosis. After crossing BBB, separated Ds@Exo can further target cells via homing effect. In vivo studies validated that significantly downregulated TGF‐β expression reprogram microenvironment, thereby reinforce chemotherapeutic effect DOX‐induced anti‐tumor immune response. effectiveness this strategy not only provide thinking designing a more intelligent based engineered exosomes but also explore effective treatment regimen GBM.

Language: Английский

Citations

21
DNA‐Capturing Manganese‐Coordinated Chitosan Microparticles Potentiate Radiotherapy via Activating the cGAS‐STING Pathway and Maintaining Tumor‐Infiltrating CD8+ T‐Cell Stemness DOI Open Access

Shuai Zhang,

Chunjie Wang, Yujie Zhu

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 16, 2025

The radiotherapy-induced release of DNA fragments can stimulate the cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator interferon genes (cGAS-STING) pathway to prime antitumor immunity, but this is expected be less potent because inefficient cytosolic delivery negatively charged fragments. In study, manganese-coordinated chitosan (CS-Mn) microparticles with selective DNA-capturing capacity are concisely prepared via a coordination-directed one-pot synthesis process potentiate immunogenicity radiotherapy. obtained CS-Mn that undergo rapid disassembly under physiological conditions selectively bind form positively DNA-CS assemblies strong electrostatic interaction between linear and molecules. They thus enable efficient in presence serum cooperate Mn2+ activate cGAS-STING dendritic cells. Upon intratumoral injection, markedly enhance efficacy radiotherapy against both irradiated distal tumors different tumor models collectively promoting tumor-infiltrating CD8+ T-cell stemness activation innate immunity. radiosensitization effect further augmented by concurrently applying anti-programmed cell death protein 1 (anti-PD-1) immunotherapy. This work highlights an ingenious strategy prepare Trojan horse-like as cGAS-STING-activating radiosensitizers for effective radioimmunotherapy.

Language: Английский

Citations

2
Recent advances of copper-based metal phenolic networks in biomedical applications DOI
Ying Zhang,

Fengxiang Hao,

Yingyu Liu

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 244, P. 114163 - 114163

Published: Aug. 14, 2024

Language: Английский

Citations

10
Amino Acid Metabolism-Regulated Nanomedicine for Enhanced Tumor Immunotherapy through Synergistic Regulation of Immune Microenvironment DOI Creative Commons

Xiuying Duan,

Yi‐Lei Zhao,

Houyang Hu

et al.

Biomaterials Research, Journal Year: 2024, Volume and Issue: 28

Published: Jan. 1, 2024

The reprogramming of tumor metabolism presents a substantial challenge for effective immunotherapy, playing crucial role in developing an immunosuppressive microenvironment. In particular, the degradation amino acid L-tryptophan (Trp) to kynurenine (Kyn) by indoleamine-pyrrole 2,3-dioxygenase 1 (IDO1) is one most clinically validated pathways immune suppression. Thus, regulating Trp/Kyn IDO1 inhibition represents promising strategy enhancing immunotherapy. Herein, metabolism-regulated nanoparticles are prepared through metal coordination-driven assembly inhibitor (NLG919) and stimulator interferon genes (STING) agonist (MSA-2) enhanced After intravenous administration, assembled could efficiently accumulate tumors, bioavailability NLG919 down-regulating Trp Kyn remodel Meanwhile, released MSA-2 evoked potent STING pathway activation triggering response. antitumor immunity induced significantly inhibited development primary metastatic as well B16 melanoma. Overall, this study provided novel paradigm immunotherapy synergistic activation.

Language: Английский

Citations

7
Metal-polyphenol self-assembled nanodots for NIR-II fluorescence imaging-guided chemodynamic/photodynamic therapy-amplified ferroptosis DOI
Yang Zhu,

Chengyu Ding,

Wenhua Fang

et al.

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 185, P. 361 - 370

Published: July 23, 2024

Language: Английский

Citations

6
Biodegradable Persistent Luminescence Nanoparticles as Pyroptosis Inducer for High‐Efficiency Tumor Immunotherapy DOI Creative Commons
Lin Liu, Junpeng Shi, Jin‐Yuan Wang

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(39)

Published: Aug. 19, 2024

Abstract Pyroptosis possesses potent antitumor immune activity, making pyroptosis inducer development a promising direction for tumor immunotherapy. Persistent luminescence nanoparticles (PLNPs) are highly sensitive optical probes extensively employed in diagnosis and therapy. However, based on PLNPs has not been reported yet. Herein, polyethylene glycol–poly lactic acid‐co‐glycolic acid (PEG–PLGA: PP) modified biodegradable CaS:Eu 2+ (CSE@PP) synthesized as immunotherapy the first time. The CSE@PP biowindow persistent (PersL) pH‐responsive degradation properties, allowing it to remain stable under neutral pH but degrade when exposed weak (pH < 6.5). During within tumor, constantly releases H 2 S Ca while its PersL gradually fades away. Thus, signal can self‐monitor release. Furthermore, released result mitochondrial dysfunction inactivation of reactive oxygen species scavenging enzymes, synergistic facilitating intracellular oxidative stress, which induces caspase‐1/GSDM‐D dependent subsequent responses. In word, is confirmed that release pyroptosis‐mediated Immunotherapy. This work will facilitate biomedical applications inspire pyroptosis‐induced

Language: Английский

Citations

5
Coacervate‐Derived Assembly of Poly(ethylene glycol) Nanoparticles for Combinational Tumor Therapy DOI Open Access
Hanru Liu, Rende Mu, Huimin Geng

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Coacervates have garnered significant attention as potential drug carriers. However, the instability resulting from their intrinsic membrane-free nature restricts application of coacervates in delivery. Herein, engineering poly(ethylene glycol) nanoparticles (PEG NPs) is reported using composed PEG and polyphenols templates, where subsequently cross-linked based on different chemistries (e.g., thiol-disulfide exchange, click chemistry, Schiff base reaction). The assembly strategy avoids template removal process resultant NPs exhibit excellent stability physiological environment compared to coacervates. presence enables loading various cargos including metal ions (i.e., Ru, Gd, Mn, Fe) molecules doxorubicin), which demonstrates promise magnetic resonance imaging combinational tumor therapy. This work provides a promising promote development coacervate-derived delivery system for biomedical applications.

Language: Английский

Citations

0
Dendrimer-Mediated Generation of a Metal-Phenolic Network for Antibody Delivery to Elicit Improved Tumor Chemo/Chemodynamic/Immune Therapy DOI
Zhiqiang Wang, Yunqi Guo, Gaoming Li

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

To simplify the composition and improve efficacy of metal-phenolic network (MPN)-based nanomedicine, herein, we designed an MPN platform to deliver programmed death ligand-1 (PD-L1) antibody (anti-PD-L1) for combined tumor chemo/chemodynamic/immune therapy. Here, generation 5 poly(amidoamine) dendrimers conjugated with gossypol (Gos) through boronic ester bonds were used as a synthetic polyphenol coordinate Mn2+, then complexed anti-PD-L1 obtain nanocomplexes (for short, DPGMA). The prepared DPGMA exhibited good water dispersibility hydrodynamic size 166.3 nm tumor-microenvironment-responsive drug release behavior. integration Gos Mn2+ within resulted in significant inhibition immunogenic cell activation Gos-mediated chemotherapy Mn2+-catalyzed chemodynamic therapy, respectively, thereby leading dendritic maturation due role played mediate stimulator interferon genes (STING) pathway. Moreover, promoted recognition uptake by PD-L1-overexpressed tumors targeting, achieving combinational therapy mouse melanoma model, where immunotherapy modes three parts via chemotherapy/CDT-mediated ICD, Mn2+-mediated STING activation, antibody-mediated immune checkpoint blockade. With Mn2+-endowed r1 relaxivity (1.38 mM–1 s–1), can also be MR imaging. dendrimer-mediated may developed advanced nanomedicine tackle other cancer types.

Language: Английский

Citations

0
Ergothioneine attenuates psoriasis symptoms through modulation of M1/M2 macrophage polarisation via the NF-κB/JAK-STAT3 pathway DOI Creative Commons
Ang Li,

Yanjie Liu,

Ping Yu

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 19, 2025

The underlying cause of psoriasis, a chronic inflammatory skin condition driven by an immune response, remains topic active investigation and is not yet fully elucidated. Recent studies have revealed that ergothioneine, small molecule sulfur-containing histidine derivative can be ingested from the daily diet accumulated in body, exhibits antioxidant capacity comparable to glutathione. Nevertheless, there paucity empirical data concerning precise impact ergothioneine context anti-inflammatory processes, particularly psoriasis. In light aforementioned considerations, present study was undertaken with objective conducting comprehensive evaluation potential (EGT) investigate its on pathogenesis efficacy EGT reducing extent dorsal lesions psoriasis model mice confirmed through vivo experimental observation. Furthermore, inhibitory effect responses at cellular level investigated, specifically LPS-induced mouse macrophage (RAW264.7) human keratinocyte-forming cell (HaCaT) models. results demonstrated introduction different concentrations into resulted notable effects, as evidenced reduction dose dependent decline key cytokines, including interleukin-1β (IL-1β), cyclooxygenase-2 (COX-2) tumour necrosis factor-α (TNF-α). observed reverse LPS induced increase ratio M1 M2 macrophages. also markedly suppress phosphorylation JAK/STAT3 NF-κB, offering novel insight mechanism EGT. conclusion, findings consistently had significant ameliorative imiquimod-induced modulating NF-κB/JAK-STAT3 signalling pathway. This provides strong rationale for application treatment.

Language: Английский

Citations

0
Harnessing Plasmonic and Nanofluidic Synergies with Gold‐Embedded Graphene Oxide Frameworks for Osmotic Energy Harvesting DOI Open Access
Ru‐Song Zhao, Rongrong Zhang,

Feihong Hu

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Abstract With the growing demand for sustainable energy and environmental solutions, osmotic harvesting has become a promising technology, but challenges in membrane stability multifunctionality remain. This study introduces novel graphene oxide composite (GO‐Au@UiO‐66‐NH 2 ‐PSSA, GAUP) that achieves excellent conversion multifunctionality. The hierarchical pore structure UiO‐66‐NH ensures optimized ion transport paths selective sieving. When GAUP is photoexcited, localized surface plasmon resonance (LSPR) effect of gold nanoparticles (Au NPs) generates abundant hot electrons, which migrate from heterojunction interface are captured by UiO‐66‐NH₂ to produce photogenerated holes, reducing electron‐hole recombination enhancing photocurrent, thus achieving high‐performance (16.5 W m −2 ). It dye degradation rate over 90% wastewater bactericidal 99% against Gram‐negative bacteria, reflecting its strong remediation capability. effectively addresses ongoing systems treatment, representing transformative advancement nanofluidic technology. Future research may focus on improving broader practical applications, promoting deeper integration renewable solutions with management.

Language: Английский

Citations

0