Benzobisthiadiazole-Based Small Molecular Near-Infrared-II Fluorophores: From Molecular Engineering to Nanophototheranostics

ACS Nano, Journal Year: 2024, Volume and Issue: 18(6), P. 4683 - 4703

Published: Jan. 31, 2024

Organic fluorescent molecules with emission in the second near-infrared (NIR-II) biological window have aroused increasing investigation cancer phototheranostics. Among these studies, Benzobisthiadiazole (BBT), high electron affinity, is widely utilized as acceptor constructing donor–acceptor–donor (D-A-D) structured fluorophores intensive (NIR) absorption and NIR-II fluorescence. Until now, numerous BBT-based dyes been employed tumor phototheranostics due to their exceptional structure tunability, biocompatibility, photophysical properties. This review systematically overviews research progress of small molecular focuses on molecule design bioapplications. First, engineering strategies fine-tune properties high-performance are discussed detail. Then, applications optical imaging phototherapy highlighted. Finally, current challenges future prospects also summarized. believed significantly promote further BBT-derived for

Language: Английский

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Aptamer-Based Smart Targeting and Spatial Trigger–Response Drug-Delivery Systems for Anticancer Therapy

Biomedicines, Journal Year: 2024, Volume and Issue: 12(1), P. 187 - 187

Published: Jan. 15, 2024

In recent years, the field of drug delivery has witnessed remarkable progress, driven by quest for more effective and precise therapeutic interventions. Among myriad strategies employed, integration aptamers as targeting moieties stimuli-responsive systems emerged a promising avenue, particularly in context anticancer therapy. This review explores cutting-edge advancements targeted drug-delivery systems, focusing on platforms enhanced spatial aptamer-based we delve into versatile applications aptamers, examining their conjugation with gold, silica, carbon materials. The synergistic interplay between these materials is discussed, emphasizing potential achieving delivery. Additionally, explore an emphasis Tumor microenvironment-responsive nanoparticles are elucidated, capacity to exploit dynamic conditions within cancerous tissues controlled release detailed. External strategies, including ultrasound-mediated, photo-responsive, magnetic-guided examined role effects. integrates diverse approaches precision medicine, showcasing revolutionize

Language: Английский

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Molecular Engineering of Plasma Membrane and Mitochondria Dual‐Targeted NIR‐II AIE Photosensitizer Evoking Synergetic Pyroptosis and Apoptosis

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(5)

Published: Nov. 22, 2023

Phototherapy provides a noninvasive and spatiotemporal controllable paradigm to inhibit the evasion of programmed cell death (PCD) tumors. However, conventional photosensitizers (PSs) often induce single PCD process, resulting in insufficient photodamage severely impeding their application scopes. In this study, molecular engineering is conducted by adjusting electron donors develop an aggregation-induced NIR-II emissive PS (DPITQ) for plasma membrane mitochondria dual-targeted tumor therapy evoking synergetic pyroptosis apoptosis. DPITQ displays boosted type I II reactive oxygen species generation as well high photothermal conversion efficacy (43%) after laser irradiation 635 nm. The excellent biocompatibility appropriate lipophilicity help specifically anchor cancer cells. Furthermore, photosensitized can disrupt intact cause mitochondrial dysfunction, ultimately causing concurrent apoptosis suppress proliferation even under hypoxia. It noteworthy that nanoparticles (NPs) present clear fluorescence imaging capability on venous vessels nude mice. Notably, NPs exert efficient imaging-guided phototherapy both multicellular spheroids vivo, maximum destruction tumors but minimum adverse effects normal tissue.

Language: Английский

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Tunable Nanoparticles with Aggregation‐Induced Emission Heater for Precise Synergistic Photothermal and Thermodynamic Oral Cancer Therapy of Patient‐Derived Tumor Xenograft

Advanced Science, Journal Year: 2023, Volume and Issue: 10(17)

Published: April 20, 2023

The fluorophores in the second near-infrared (NIR-II) biological window (1000 - 1700 nm) show great application prospects fields of biology and optical communications. However, both excellent radiative transition nonradiative cannot be achieved simultaneously for majority traditional fluorophores. Herein, tunable nanoparticles formulated with aggregation-induced emission (AIE) heater are developed rationally. system can implemented via development an ideal synergistic that not only produce photothermal from nonspecific triggers but also trigger carbon radical release. Once accumulating tumors subsequently being irradiated 808 nm laser, (NMB@NPs) encapsulated NMDPA-MT-BBTD (NMB) splitted due to effect NMB, leading decomposition azo bonds nanoparticle matrix generate radical. Accompanied by fluorescence image-guided thermodynamic therapy (TDT) (PTT) which significantly inhibited growth oral cancer negligible systemic toxicity is synergistically. Taken together, this AIE luminogens-based photothermal-thermodynamic strategy brings a new insight into design superior versatile fluorescent NPs precise biomedical applications holds promise enhance therapeutic efficacy therapy.

Language: Английский

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Activated aggregation‐induced emission therapeutics agents for triggering regulated cell death

Aggregate, Journal Year: 2024, Volume and Issue: 5(3)

Published: Jan. 22, 2024

Abstract The induction of regulated cell death (RCD) through photo/ultrasound sensitization therapeutic agents has gained significant attention as a vital approach to combat drug resistance in tumors. Aggregation‐induced emission (AIE) generate reactive oxygen species activation, which can synergize with RCD inducers or directly induce RCD, ultimately resulting the tumor cells. presented comprehensive review delves into recent advancements AIE designed trigger inducers, encompassing apoptosis, necroptosis, pyroptosis, immunogenic death, autophagy, ferroptosis, and cuproptosis. Additionally, intricate regulatory mechanisms activatory‐AIE therapeutics influence distinct pathways are examined. A forward‐looking perspective on future developments pertinent challenges within this exciting realm is presented, anticipating continued evolution activatable transformative enhance therapy.

Language: Английский

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Utilization of aggregation‐induced emission materials in urinary system diseases

Aggregate, Journal Year: 2024, Volume and Issue: 5(5)

Published: May 10, 2024

Abstract With the development of aggregation‐induced emission (AIE) materials, drawbacks conventional fluorescence materials subjected to aggregation‐caused quenching (ACQ) have been resolved. This has allowed for improvement novel AIE fluorescent that exhibit enhanced photostability, a higher signal‐to‐noise ratio, and better imaging quality. Meanwhile, phototherapeutic effect garnered widespread attention in realm tumor treatment. The distinct physiological anatomical characteristics urinary system make it suitable use materials. Additionally, AIE‐based phototherapy provides superior solution deal with weaknesses treatments urologic neoplasms. In this review, scientific advancement on diseases since emergence concept is reviewed detail. review highlights promise biomarkers detection, (FLI) vivo vitro, phototherapy, synergistic therapy from both diagnostic therapeutic viewpoints. It firmly believed hold immense untapped potential diagnosis treatment disease, as well all human body.

Language: Английский

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Advances in Nanodynamic Therapy for Cancer Treatment

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(7), P. 648 - 648

Published: April 8, 2024

Nanodynamic therapy (NDT) exerts its anti-tumor effect by activating nanosensitizers to generate large amounts of reactive oxygen species (ROS) in tumor cells. NDT enhances tumor-specific targeting and selectivity leveraging the microenvironment (TME) mechanisms that boost immune responses. It also minimizes damage surrounding healthy tissues cytotoxicity cells, showing promise cancer treatment, with significant potential. This review covers research progress five major nanodynamic therapies: photodynamic (PDT), electrodynamic (EDT), sonodynamic (SDT), radiodynamic (RDT), chemodynamic (CDT), emphasizing role advanced nanotechnology development for purposes. The mechanisms, effects, challenges faced these NDTs are discussed, along their respective solutions enhancing efficacy, such as pH response, delivery, combined immunotherapy. Finally, this briefly addresses clinical translation NDT.

Language: Английский

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Albumin-Energized NIR-II Cyanine Dye for Fluorescence/Photoacoustic/Photothermal Multi-Modality Imaging-Guided Tumor Homologous Targeting Photothermal Therapy

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Endowing cyanine dyes with hydrophilicity, long blood circulation, tumor targeting, and robust therapeutic efficacy in the second near-infrared (NIR-II) window is challenging for cancer treatment. Herein, we develop cell membrane-coated albumin-NIR-II dye assemblies, denoted as LZ-1105@HAm, to optimize photophysical properties of aqueous solution NIR-II fluorescence (FL)/photoacoustic (PA)/photothermal (PT) multimodality imaging-guided homologous targeting photothermal therapy. LZ-1105@HAm exhibits good extends half-life circulation from 0.634 ± 0.058 1.919 0.107 h, enhances FL/PA/PT imaging capabilities vitro vivo, improves conversion efficiency 34.6% 45.4%. Additionally, membrane coating confers assemblies tumor-specific capability, increasing accumulation enabling efficient ablation. Upon 1064 nm laser irradiation, demonstrates significantly improved efficacy. This research provides a strategy constructing dye-based nanotheranostics potential clinical application prospects.

Language: Английский

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D–A–D organic fluorescent probes for NIR-II fluorescence imaging and efficient photothermal therapy of breast cancer

Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(5), P. 1320 - 1331

Published: Jan. 1, 2024

Schematic illustrations of the preparation TCT-NPs and their application in NIR-II fluorescence imaging-guided efficient photothermal therapy for breast cancer.

Language: Английский

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Stimuli-responsive nanotheranostic systems conjugated with AIEgens for advanced cancer bio-imaging and treatment

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 373, P. 766 - 802

Published: Aug. 3, 2024

Language: Английский

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