Reproductive Biology and Endocrinology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Nov. 7, 2024
Mesenchymal
stem
cells
(MSCs)
have
shown
potential
in
repairing
chemotherapy-induced
premature
ovarian
failure
(POF).
However,
challenges
such
as
cell
loss
and
immune
phagocytosis
post-transplantation
hinder
their
application.
Due
to
easy
safe
handling,
vitro
culture
is
widely
available
for
drug
screening,
pathophysiological
research,
fertilization.
MSCs
could
exhibit
therapeutic
capacity
injury,
avoid
tissue
system.
Therefore,
this
study
utilizes
an
system
investigate
the
reparative
of
human
umbilical
cord
mesenchymal
(hUCMSCs)
mechanism.
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 27, 2025
Abstract
Chronic
pancreatitis
(CP)
is
a
long‐standing
progressive
fibrosis
and
has
long
been
considered
incurable,
which
remains
heavy
health
burden
worldwide.
Mesenchymal
stem
cells
(MSCs)
with
anti‐fibrosis
properties
are
currently
used
in
the
treatment
of
fibroinflammatory
diseases.
However,
its
therapeutic
effect
limited
mainly
due
to
two
main
types
pathological
barriers
CP:
1)
Fibrotic
collagen
hinders
cell
delivery,
2)
Malignant
microenvironment
attacks
inactivation.
Here,
MSCs‐based
exogenous
nitric
oxide
(NO)
delivery
system
(MSCs‐Lip@RNO)
constructed.
In
MSCs‐Lip@RNO,
NO
not
only
can
be
booster
regulate
fibers,
relieve
vascular
compression
enhance
accumulation
MSCs
whole
pancreas,
but
also
form
protective
gas
layer
on
surface,
enhances
MSCs.
CP
rat
model,
pancreatic
injury
reduced
7
days
after
single
dose
administration
this
long‐acting
Collectively,
study
offers
promising
strategy
for
enhancing
efficacy
break
treatment.
AJP Cell Physiology,
Journal Year:
2023,
Volume and Issue:
325(5), P. C1212 - C1227
Published: Sept. 18, 2023
Ferroptosis
has
been
proven
critical
for
survival
following
bone
marrow
mesenchymal
stem
cells
(BMSCs)
explantation.
Suppression
of
ferroptosis
in
BMSCs
will
be
a
valid
tactic
to
elevate
the
therapeutic
potential
engrafted
BMSCs.
Prominin2
is
pentaspanin
protein
involved
mediating
iron
efflux
and
thus
modulates
resistance
ferroptosis,
but
its
role
tert-butyl
hydroperoxide
(TBHP)-induced
remains
elusive.
We
examined
biological
effect
prominin2
vitro
vivo
by
using
cell
proliferation
assay,
reactive
oxygen
species
(ROS)
examination,
malondialdehyde
glutathione
(GSH)
Western
blot,
quantitative
reverse
transcription-PCR,
immunofluorescence
staining
gene
expression
inhibition
activation,
co-immunoprecipitation
(CO-IP)
radiographic
analysis,
histopathological
analysis.
Our
study
demonstrated
that
activity
was
impaired
TBHP-induced
ferroptosis.
found
PROM2
(encoding
prominin2)
activation
delayed
onset
knockdown
deteriorated
course
CO-IP,
exerts
antiferroptosis
effects
inhibiting
BTB
CNC
homology
1
(BACH1)
promotes
ROS
generation,
potent
antioxidant
oxidative
stress
(OS)-induced
including
elevating
BMSCs'
rate
enhancing
GSH
contents.
with
overexpression
also
partially
progression
intervertebral
disk
degeneration
vivo,
as
illustrated
less
loss
height
lower
histological
scores.
findings
revealed
mechanism
prominin2/BACH1/ROS
axis
participates
strengthening
this
promising
maintain
after
Cell Death and Disease,
Journal Year:
2024,
Volume and Issue:
15(7)
Published: July 2, 2024
Abstract
Myelodysplastic
syndromes
(MDS)
are
clonal
hematopoietic
malignancies
and
seriously
threaten
people’s
health.
Current
therapies
include
bone
marrow
transplantation
several
hypomethylating
agents.
However,
many
elderly
patients
cannot
benefit
from
develop
drug
resistance
to
agents,
making
it
urgent
explore
novel
therapy.
RSL3
can
effectively
induce
ferroptosis
in
various
tumors
combination
of
agents
is
promising
treat
tumors.
its
effect
MDS
was
unknown.
In
this
study,
we
found
that
inhibited
cell
proliferation
through
inducing
ROS-dependent
apoptosis.
Bcl-2
expression
increased
caspase
3
PARP
cleavage.
RNA-seq
analysis
revealed
MYB
may
be
a
potential
target
RSL3.
Rescue
experiments
showed
overexpression
rescue
inhibition
caused
by
Cellular
thermal
shift
assay
binds
exert
function.
Furthermore,
tumor
growth
decreased
vivo.
More
importantly,
the
viability
mononuclear
cells
(BMMCs)
isolated
patients,
had
synergistic
with
DAC
cells.
Our
studies
have
uncovered
as
compound
MYB/Bcl-2
signaling
pathway
for
treatment.
Frontiers in Genetics,
Journal Year:
2023,
Volume and Issue:
14
Published: Nov. 6, 2023
Branched-chain
amino
acid
aminotransferases,
widely
present
in
natural
organisms,
catalyze
bidirectional
transfer
between
branched-chain
acids
and
α-ketoacids
cells.
aminotransferases
play
an
important
role
the
metabolism
of
acids.
In
this
paper,
interspecific
evolution
biological
characteristics
are
introduced,
related
research
animals,
plants,
microorganisms
humans
is
summarized
molecular
mechanism
aminotransferase
analyzed.
It
has
been
found
that
disorders
closely
to
various
diseases
animals
such
as
diabetes,
cardiovascular
diseases,
brain
neurological
cancer.
particular,
development
tumors.
have
used
potential
targets
for
cancers.
This
article
reviews
on
aiming
provide
a
reference
clinical
targeted
therapy
different
Advanced Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 24, 2024
Human
induced
pluripotent
stem
cell
derived
hepatocytes
(hiPSC-heps)
hold
promising
value
for
acute
liver
failure
(ALF)
treatment,
while
their
therapeutic
efficacy
is
usually
limited
by
low
bioactivity
and
untargeted
in
vivo
accumulation.
Here,
inspired
vascularity
supporting
cellular
architectures
the
tissues
organs,
a
novel
vascularized
hiPSC-heps
spheroid
based
on
microfluidic
microcapsules
presented
repair
via
orthotopic
transplantation.
The
are
comprised
of
aqueous
cores
that
facilitate
hiPSC-hep
aggregating
into
spheroids,
hybrid
hydrogel
shells
sodium
alginate
hyaluronic
acid
methacryloyl
(HAMA).
By
selectively
degrading
alginate,
imparted
with
porous
HAMA
shells,
which
not
only
allowed
human
umbilical
vein
endothelial
cells
(HUVECs)
to
attach
form
networks,
but
also
facilitated
communication
between
HUVECs
hiPSC-heps.
specific
spatial
distributions
these
spheroids
can
provide
nutrition
support,
promote
hepatic
functions,
avoid
immune
attacks.
Based
features,
it
illustrated
failing
more
effectively,
indicating
practical
values
clinical
repair.
Reproductive Biology and Endocrinology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Nov. 7, 2024
Mesenchymal
stem
cells
(MSCs)
have
shown
potential
in
repairing
chemotherapy-induced
premature
ovarian
failure
(POF).
However,
challenges
such
as
cell
loss
and
immune
phagocytosis
post-transplantation
hinder
their
application.
Due
to
easy
safe
handling,
vitro
culture
is
widely
available
for
drug
screening,
pathophysiological
research,
fertilization.
MSCs
could
exhibit
therapeutic
capacity
injury,
avoid
tissue
system.
Therefore,
this
study
utilizes
an
system
investigate
the
reparative
of
human
umbilical
cord
mesenchymal
(hUCMSCs)
mechanism.
