Small,
Journal Year:
2024,
Volume and Issue:
21(1)
Published: Oct. 23, 2024
Abstract
Over
the
past
decade,
precision
medicine
has
garnered
increasing
attention,
making
significant
strides
in
discovering
new
therapeutic
drugs
and
mechanisms,
resulting
notable
achievements
symptom
alleviation,
pain
reduction,
extended
survival
rates.
However,
limited
target
specificity
of
primary
inter‐individual
differences
have
often
necessitated
high‐dosage
strategies,
leading
to
challenges
such
as
restricted
deep
tissue
penetration
rates
systemic
side
effects.
Material
science
advancements
present
a
promising
avenue
for
these
issues.
By
leveraging
distinct
internal
features
diseased
regions
application
specific
external
stimuli,
responsive
materials
can
be
tailored
achieve
targeted
delivery,
controllable
release,
biochemical
reactions.
This
review
aims
highlight
latest
stimuli‐responsive
their
potential
medicine.
Initially,
we
introduce
disease‐related
stimuli
capable
elucidating
reaction
principles
functional
groups.
Subsequently,
provide
detailed
analysis
representative
pre‐clinical
across
various
clinical
applications,
including
enhancements
treatment
cancers,
injury
diseases,
inflammatory
infection
high‐throughput
microfluidic
biosensors.
Finally,
discuss
some
challenges,
off‐target
effects,
long‐term
impacts
nano‐materials,
ethical
concerns,
offer
insights
into
future
perspectives
materials.
Small,
Journal Year:
2023,
Volume and Issue:
20(8)
Published: Oct. 10, 2023
Abstract
Proteolysis‐targeting
chimeras
(PROTACs)
can
provide
promising
opportunities
for
cancer
treatment,
while
precise
regulation
of
their
activities
remains
challenging
to
achieve
effective
and
safe
therapeutic
outcomes.
A
semiconducting
polymer
nanoPROTAC
(SPN
FeP
)
is
reported
that
ultrasound
(US)
tumor
microenvironment
dual‐programmable
PROTAC
activity
deep‐tissue
sonodynamic‐ferroptosis
activatable
immunotherapy.
SPN
formed
through
a
nano‐precipitation
sonodynamic
polymer,
ferroptosis
inducer,
newly
synthesized
molecule.
The
polymers
work
as
sonosensitizers
produce
singlet
oxygen
(
1
O
2
via
effect
under
US
irradiation,
inducers
react
with
intratumoral
hydrogen
peroxide
(H
generate
hydroxyl
radical
(·OH).
Such
reactive
species
(ROS)
generation
not
only
triggers
immunogenic
cell
death
(ICD),
but
also
induces
on‐demand
delivery
molecules
into
sites.
effectively
activated
nanoPROTACs
degrade
nicotinamide
phosphoribosyl
transferase
(NAMPT)
suppress
infiltration
myeloid‐derived
suppressive
cells
(MDSCs),
thus
promoting
antitumor
immunity.
In
such
way,
mediates
immunotherapy
entirely
inhibiting
growths
in
both
subcutaneous
2‐cm
tissue‐covered
deep
mouse
models.
This
study
presents
strategy
based
on
PROTACs
combinational
therapy.
Small,
Journal Year:
2024,
Volume and Issue:
21(1)
Published: Oct. 23, 2024
Abstract
Over
the
past
decade,
precision
medicine
has
garnered
increasing
attention,
making
significant
strides
in
discovering
new
therapeutic
drugs
and
mechanisms,
resulting
notable
achievements
symptom
alleviation,
pain
reduction,
extended
survival
rates.
However,
limited
target
specificity
of
primary
inter‐individual
differences
have
often
necessitated
high‐dosage
strategies,
leading
to
challenges
such
as
restricted
deep
tissue
penetration
rates
systemic
side
effects.
Material
science
advancements
present
a
promising
avenue
for
these
issues.
By
leveraging
distinct
internal
features
diseased
regions
application
specific
external
stimuli,
responsive
materials
can
be
tailored
achieve
targeted
delivery,
controllable
release,
biochemical
reactions.
This
review
aims
highlight
latest
stimuli‐responsive
their
potential
medicine.
Initially,
we
introduce
disease‐related
stimuli
capable
elucidating
reaction
principles
functional
groups.
Subsequently,
provide
detailed
analysis
representative
pre‐clinical
across
various
clinical
applications,
including
enhancements
treatment
cancers,
injury
diseases,
inflammatory
infection
high‐throughput
microfluidic
biosensors.
Finally,
discuss
some
challenges,
off‐target
effects,
long‐term
impacts
nano‐materials,
ethical
concerns,
offer
insights
into
future
perspectives
materials.
