BMJ Open,
Journal Year:
2024,
Volume and Issue:
14(1), P. e076043 - e076043
Published: Jan. 1, 2024
The
objective
of
this
study
is
to
delineate
disparities
between
patients
with
knee
osteoarthritis
(KOA)
based
on
obesity
status,
investigate
the
interplay
among
body
composition,
physical
activity
and
pain/function
in
KOA
conduct
subgroup
analyses
focusing
those
obesity.
Cross-sectional
study.
Residents
eight
communities
Shijiazhuang,
Hebei
Province,
China,
were
surveyed
from
March
2021
November
2021.
178
symptomatic
aged
40
years
or
older
included.
primary
outcome
measure
was
pain,
assessed
using
Western
Ontario
McMaster
Universities
Osteoarthritis
Index-pain
(WOMAC-P)
scale.
Secondary
measures
included
function,
evaluated
through
WOMAC-function
(WOMAC-F)
scale
Five-Time-Sit-to-Stand
Test
(FTSST).
Data
analysis
involved
t-tests,
Wilcoxon
rank-sum
tests,
χ2
linear
logistical
regression
analysis.
Participants
(n=178)
41-80
age
(median:
65,
P25-P75:
58-70),
82%
female.
Obese
(n=103)
had
worse
pain
self-reported
function
(p<0.05).
In
general
KOA,
fat
mass
positively
associated
bilateral
(β=1.21
(95%
CI
0.03
0.15)),
WOMAC-P
scores
(β=0.25
0.23
1.22)),
WOMAC-F
(β=0.28
0.35
1.29))
FTSST
(β=0.19
0.42)),
moderate-intensity
low-intensity
negatively
(β=-0.80
-0.10
-0.01))
Skeletal
Muscle
Index
(SMI)
(β=-0.16
-0.66
-0.03)).
obesity,
SMI
(β=-0.30
-3.94
-0.00)).
Patients
compared
non-obese
patients.
Greater
mass,
lower
muscle
increased
poor
function.
More
skeletal
improvement
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 23, 2025
Abstract
Insufficient
oxygen
supply
and
elevated
levels
of
reactive
species
(ROS)
in
rheumatoid
arthritis
(RA)
joints
synergistically
exacerbate
inflammation
accelerate
disease
progression.
In
this
study,
a
hybrid
nanoassembly
composed
superoxide
dismutase
(SOD)
catalase
(CAT)
conjugated
within
single
poly(ε‐caprolactone)
(PCL)
nanoparticle
is
developed
for
RA
therapy.
The
synthesized
(PSC)
drives
proximity‐dependent
cascade
reaction
that
efficiently
scavenges
ROS
generates
oxygen,
thereby
modulating
the
phenotype
inflammatory
macrophages
synovium,
significantly
inhibiting
secretion
pro‐inflammatory
cytokines,
consequently
alleviating
inflammation.
Furthermore,
PSC
functions
as
versatile
drug
delivery
platform
hydrophobic
small‐molecule
drugs.
Iguratimod
(IGU),
an
anti‐rheumatic
with
bone‐protective
properties,
incorporated
into
(PSC@IGU),
which
then
loaded
dissolvable
microneedles
(MNs)
to
enhance
efficiency.
Finally,
PSC@IGU
MNs
demonstrate
significant
therapeutic
effects
mouse
models
by
effectively
improving
joint
hypoxia,
synovial
inflammation,
preventing
bone
erosion.
This
study
highlights
potential
PSC@IGU‐loaded
treatment
RA,
indicating
their
promising
ability
bridge
basic
research
clinical
translation.
International Journal of Biological Sciences,
Journal Year:
2024,
Volume and Issue:
20(8), P. 2994 - 3007
Published: Jan. 1, 2024
Osteoarthritis
(OA)
is
a
challenging
degenerative
joint
disease
to
manage.
Previous
research
has
indicated
that
cell-free
fat
extract
(CEFFE)
may
hold
potential
for
OA
treatment.
This
study
investigated
the
role
of
Annexin
A5
(AnxA5)
within
CEFFE
in
regulating
macrophage
polarization
and
protecting
chondrocytes.
Small,
Journal Year:
2024,
Volume and Issue:
20(46)
Published: Aug. 5, 2024
Abstract
In
the
therapy
of
early‐stage
osteoarthritis,
to
accomplish
full
infiltration
subchondral
bone
and
cartilage,
target
osteoclast
chondrocyte
simultaneously
remain
challenges
in
biomaterials
design.
Herein,
a
novel
hierarchical
drug
delivery
system
is
introduced,
with
micrometer‐scale
outer
layer
spheres
composed
regenerated
silk
fibroin,
characterized
by
connected
porous
structure
through
n‐butanol
fibroin
combined
emulsion
route
freezing
method.
The
design
effectively
resists
clearance
from
joint
cavity,
ensuring
stable
prolonged
residence
time
within
space.
Additionally,
incorporates
phenylboronic
acid‐enriched
nanoparticles,
stabilized
chemical
cross‐linking,
which
encapsulate
isoliquiritin
derived
Glycyrrhiza
uralensis.
These
nanoparticles
facilitate
complete
penetration
cartilage
extracellular
matrix,
exhibit
pH‐responsive
behavior,
neutralize
reactive
oxygen
species,
enable
controlled
release,
thereby
enhancing
therapeutic
efficacy.
vitro
vivo
experiments
both
demonstrate
that
composite
micro/nanospheres
not
only
inhibit
osteoclastogenesis
loss
osteophyte
formation,
but
also
mitigate
chondrocytes
apoptosis,
reduce
oxidative
stress
associated
degeneration,
ameliorate
neuropathic
hyperalgesia,
underlying
mechanisms
being
elucidated.
study
indicates
such
an
injectable
strategy
combining
organic
Chinese
medicine
holds
substantial
promise
for
treatment
early
osteoarthritis.
Frontiers in Pharmacology,
Journal Year:
2023,
Volume and Issue:
14
Published: Aug. 11, 2023
Arthritis
is
a
common
degenerative
disease
of
joints,
which
has
become
public
health
problem
affecting
human
health,
but
its
pathogenesis
complex
and
cannot
be
eradicated.
Coptis
chinensis
(CC)
variety
active
ingredients,
natural
antibacterial
anti-inflammatory
drug.
In
which,
berberine
main
effective
ingredient,
good
therapeutic
effects
on
rheumatoid
arthritis
(RA),
osteoarthritis
(OA),
gouty
(GA).
RA,
OA
GA
are
the
three
most
types
arthritis,
relevant
not
clear.
Therefore,
molecular
mechanism
prevention
treatment
key
issues
to
paid
attention
in
clinical
practice.
general,
berberine,
palmatine,
coptisine,
jatrorrhizine,
magnoflorine
jatrorrhizine
hydrochloride
CC
play
role
treating
by
regulating
Wnt1/β-catenin
PI3K/AKT/mTOR
signaling
pathways.
this
review,
targets
were
expounded,
we
have
further
explained
potential
AHR,
CAV1,
CRP,
CXCL2,
IRF1,
SPP1,
IL-17
pathway
provide
new
idea
for
CC.
BMJ Open,
Journal Year:
2024,
Volume and Issue:
14(1), P. e076043 - e076043
Published: Jan. 1, 2024
The
objective
of
this
study
is
to
delineate
disparities
between
patients
with
knee
osteoarthritis
(KOA)
based
on
obesity
status,
investigate
the
interplay
among
body
composition,
physical
activity
and
pain/function
in
KOA
conduct
subgroup
analyses
focusing
those
obesity.
Cross-sectional
study.
Residents
eight
communities
Shijiazhuang,
Hebei
Province,
China,
were
surveyed
from
March
2021
November
2021.
178
symptomatic
aged
40
years
or
older
included.
primary
outcome
measure
was
pain,
assessed
using
Western
Ontario
McMaster
Universities
Osteoarthritis
Index-pain
(WOMAC-P)
scale.
Secondary
measures
included
function,
evaluated
through
WOMAC-function
(WOMAC-F)
scale
Five-Time-Sit-to-Stand
Test
(FTSST).
Data
analysis
involved
t-tests,
Wilcoxon
rank-sum
tests,
χ2
linear
logistical
regression
analysis.
Participants
(n=178)
41-80
age
(median:
65,
P25-P75:
58-70),
82%
female.
Obese
(n=103)
had
worse
pain
self-reported
function
(p<0.05).
In
general
KOA,
fat
mass
positively
associated
bilateral
(β=1.21
(95%
CI
0.03
0.15)),
WOMAC-P
scores
(β=0.25
0.23
1.22)),
WOMAC-F
(β=0.28
0.35
1.29))
FTSST
(β=0.19
0.42)),
moderate-intensity
low-intensity
negatively
(β=-0.80
-0.10
-0.01))
Skeletal
Muscle
Index
(SMI)
(β=-0.16
-0.66
-0.03)).
obesity,
SMI
(β=-0.30
-3.94
-0.00)).
Patients
compared
non-obese
patients.
Greater
mass,
lower
muscle
increased
poor
function.
More
skeletal
improvement
